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Article

Overexpression of lncRNA EGFR‑AS1 is associated with a poor prognosis and promotes chemotherapy resistance in non‑small cell lung cancer

Corrigendum in: /10.3892/ijo.2019.4686
  • Authors:
    • Yu-Hua Xu
    • Jian-Ren Tu
    • Tian-Tian Zhao
    • Shi-Guang Xie
    • Sheng-Bo Tang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Medicine, Jiangxi Chest Hospital, Nanchang, Jiangxi 330006, P.R. China, Department of Oncology, Jiangxi Cancer Hospital, Nanchang, Jiangxi 330029, P.R. China, Department of Respiratory Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Medical Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
  • Pages: 295-305
    |
    Published online on: November 9, 2018
       https://doi.org/10.3892/ijo.2018.4629
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Abstract

Chemoresistance is one of the most important biological elements affecting the progression and prognosis of cancer. Long non‑coding RNAs (lncRNAs) are important regulators and are aberrantly expressed in various types of cancer in humans, including non‑small cell lung cancer (NSCLC). The present study aimed to investigate the effect of lncRNAs on NSCLC resistance to chemotherapy. The relative expression level of epidermal growth factor receptor antisense RNA 1 (EGFR‑AS1) was quantified by reverse transcription-quantitative polymerase chain reaction analysis in NSCLC tissues, paired adjacent normal tissues, patient plasma and NSCLC cell lines, and its association with prognosis was assessed by multivariate analysis. The biological functions of EGFR‑AS1 in NSCLC cells were determined in vitro. It was found that EGFR‑AS1 was abnormally upregulated in NSCLC tissues compared with adjacent normal lung tissues. Furthermore, patients with NSCLC with increased expression of EGFR‑AS1 had a poor prognosis. EGFR‑AS1 knockdown significantly inhibited NSCLC malignancy in vitro, including cell proliferation and chemoresistance. Furthermore, the expression levels of EGFR‑AS1 were increased in plasma samples from patients with cisplatin-based chemotherapy resistance. Bioinformatics analysis and a luciferase reporter assay confirmed that EGFR‑AS1 mediated cell proliferation and chemoresistance through directly binding to microRNA‑223. Therefore, EGFR‑AS1 overexpression-induced chemoresistance can contribute to poor prognosis in NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Xu Y, Tu J, Zhao T, Xie S and Tang S: Overexpression of lncRNA EGFR‑AS1 is associated with a poor prognosis and promotes chemotherapy resistance in non‑small cell lung cancer Corrigendum in /10.3892/ijo.2019.4686. Int J Oncol 54: 295-305, 2019.
APA
Xu, Y., Tu, J., Zhao, T., Xie, S., & Tang, S. (2019). Overexpression of lncRNA EGFR‑AS1 is associated with a poor prognosis and promotes chemotherapy resistance in non‑small cell lung cancer Corrigendum in /10.3892/ijo.2019.4686. International Journal of Oncology, 54, 295-305. https://doi.org/10.3892/ijo.2018.4629
MLA
Xu, Y., Tu, J., Zhao, T., Xie, S., Tang, S."Overexpression of lncRNA EGFR‑AS1 is associated with a poor prognosis and promotes chemotherapy resistance in non‑small cell lung cancer Corrigendum in /10.3892/ijo.2019.4686". International Journal of Oncology 54.1 (2019): 295-305.
Chicago
Xu, Y., Tu, J., Zhao, T., Xie, S., Tang, S."Overexpression of lncRNA EGFR‑AS1 is associated with a poor prognosis and promotes chemotherapy resistance in non‑small cell lung cancer Corrigendum in /10.3892/ijo.2019.4686". International Journal of Oncology 54, no. 1 (2019): 295-305. https://doi.org/10.3892/ijo.2018.4629
Copy and paste a formatted citation
x
Spandidos Publications style
Xu Y, Tu J, Zhao T, Xie S and Tang S: Overexpression of lncRNA EGFR‑AS1 is associated with a poor prognosis and promotes chemotherapy resistance in non‑small cell lung cancer Corrigendum in /10.3892/ijo.2019.4686. Int J Oncol 54: 295-305, 2019.
APA
Xu, Y., Tu, J., Zhao, T., Xie, S., & Tang, S. (2019). Overexpression of lncRNA EGFR‑AS1 is associated with a poor prognosis and promotes chemotherapy resistance in non‑small cell lung cancer Corrigendum in /10.3892/ijo.2019.4686. International Journal of Oncology, 54, 295-305. https://doi.org/10.3892/ijo.2018.4629
MLA
Xu, Y., Tu, J., Zhao, T., Xie, S., Tang, S."Overexpression of lncRNA EGFR‑AS1 is associated with a poor prognosis and promotes chemotherapy resistance in non‑small cell lung cancer Corrigendum in /10.3892/ijo.2019.4686". International Journal of Oncology 54.1 (2019): 295-305.
Chicago
Xu, Y., Tu, J., Zhao, T., Xie, S., Tang, S."Overexpression of lncRNA EGFR‑AS1 is associated with a poor prognosis and promotes chemotherapy resistance in non‑small cell lung cancer Corrigendum in /10.3892/ijo.2019.4686". International Journal of Oncology 54, no. 1 (2019): 295-305. https://doi.org/10.3892/ijo.2018.4629
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