Open Access

S100A9 promotes the proliferation and migration of cervical cancer cells by inducing epithelial‑mesenchymal transition and activating the Wnt/β‑catenin pathway

  • Authors:
    • He Zha
    • Xueru Li
    • Hui Sun
    • Liang Duan
    • Shimei Yuan
    • Huan Li
    • Aifang Li
    • Yue Gu
    • Jiali Zhao
    • Jiaqing Xie
    • Lan Zhou
  • View Affiliations

  • Published online on: May 2, 2019     https://doi.org/10.3892/ijo.2019.4793
  • Pages: 35-44
  • Copyright: © Zha et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

S100 calcium‑binding protein A9 (S100A9), a member of the S100 protein family, is often upregulated in various cancers, including cervical cancer. Elevated S100A9 expression is thought to serve an important role in tumorigenesis; however, the exact role of S100A9 in the modulation of cervical cancer and the underlying molecular mechanism remain unknown. In the present study, we aimed to investigate the effects of S100A9 on the proliferation and migration of cervical cancer cells, as well as the molecular mechanisms underlying these effects. Our results demonstrated that endogenous expression of S100A9 in SiHa and CaSki cell lines was significantly higher than in the HeLa cell line. As expected, overexpression of S100A9 enhanced the proliferation and migration of cervical cancer cells. In addition, S100A9 overexpression induced epithelial‑mesenchymal transition (EMT) as determined by reduced expression levels of the epithelial marker E‑cadherin, whereas the expression levels of the mesenchymal marker vimentin were upregulated. Furthermore, it was reported that the effects of S100A9 in the modulation of cervical cancer cells were mediated through the Wnt/β‑catenin signaling pathway as β‑catenin knockdown significantly suppressed the ability of S100A9 to enhance the proliferation and migration of cervical cancer cells. Collectively, these findings suggest that S100A9 promoted the proliferation and migration of cervical cancer cell lines. Furthermore, the underlying molecular mechanisms may be partially attributed to the induction of EMT and activation of the Wnt/β‑catenin signaling pathway.
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July-2019
Volume 55 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Zha H, Li X, Sun H, Duan L, Yuan S, Li H, Li A, Gu Y, Zhao J, Xie J, Xie J, et al: S100A9 promotes the proliferation and migration of cervical cancer cells by inducing epithelial‑mesenchymal transition and activating the Wnt/β‑catenin pathway. Int J Oncol 55: 35-44, 2019
APA
Zha, H., Li, X., Sun, H., Duan, L., Yuan, S., Li, H. ... Zhou, L. (2019). S100A9 promotes the proliferation and migration of cervical cancer cells by inducing epithelial‑mesenchymal transition and activating the Wnt/β‑catenin pathway. International Journal of Oncology, 55, 35-44. https://doi.org/10.3892/ijo.2019.4793
MLA
Zha, H., Li, X., Sun, H., Duan, L., Yuan, S., Li, H., Li, A., Gu, Y., Zhao, J., Xie, J., Zhou, L."S100A9 promotes the proliferation and migration of cervical cancer cells by inducing epithelial‑mesenchymal transition and activating the Wnt/β‑catenin pathway". International Journal of Oncology 55.1 (2019): 35-44.
Chicago
Zha, H., Li, X., Sun, H., Duan, L., Yuan, S., Li, H., Li, A., Gu, Y., Zhao, J., Xie, J., Zhou, L."S100A9 promotes the proliferation and migration of cervical cancer cells by inducing epithelial‑mesenchymal transition and activating the Wnt/β‑catenin pathway". International Journal of Oncology 55, no. 1 (2019): 35-44. https://doi.org/10.3892/ijo.2019.4793