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The EMT transcription factor, Twist1, as a novel therapeutic target for pulmonary sarcomatoid carcinomas

  • Authors:
    • Tieju Liu
    • Xiulan Zhao
    • Xu Zheng
    • Yanjun Zheng
    • Xueyi Dong
    • Nan Zhao
    • Shihan Liao
    • Baocun Sun
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Tianjin Medical University, Tianjin 300070, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 750-760
    |
    Published online on: January 29, 2020
       https://doi.org/10.3892/ijo.2020.4972
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Abstract

Pulmonary sarcomatoid carcinomas (PSCs) are a rare subtype of non‑small‑cell lung cancer and are typically biphasic neoplasms. No effective treatment for PSCs is currently available in clinical practice. The expression of the epithelial‑mesenchymal transition (EMT) transcription factors, Twist1, Slug and Snail, as well as the EMT phenotype and vasculogenic mimicry (VM) were analysed in 41 PSC and 79 pulmonary squamous carcinoma (PSCC) samples. Compared with the PSCCs, the PSCs exhibited an EMT phenotype and VM, and they also exhibited an increased expression of the Twist1, Slug, Snail and VM markers. Twist1 expression was associated with metastasis and TNM stage. Twist1‑positive patients exhibited a poorer prognosis for overall survival (OS) than those with Twist1‑negative PSCs. Transforming growth factor β1 (TGFβ1) was used to induce an EMT transition in a PSCC cell line. SK‑MES‑1 cells treated with TGFβ1 exhibited an increased expression of Twist1. The EMT phenotype, VM and increased migratory and invasive abilities were induced following TGFβ1 treatment. Importantly, in cells treated with TGFβ1, the EMT phenotype was reversed, VM marker expression was decreased, and the migratory and invasive ability of the PSCC cell line was decreased following Twist1 knockdown. Collectively, this study provides a new perspective of Twist1 in the aggressiveness of PSCs. The identification of Twist1 as an independent marker of poor prognoses may lead to the development of novel strategies for improving the treatment of patients with PSC.
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View References

1 

Mengoli MC, Longo FR, Fraggetta F, Cavazza A, Dubini A, Ali G, Guddo F, Gilioli E, Bogina G, Nannini N, et al: The 2015 world health organization classification of lung tumors: New entities since the 2004 classification. Pathologica. 110:39–67. 2018.PubMed/NCBI

2 

Mignard X, Ruppert AM, Antoine M, Vasseur J, Girard N, Mazières J, Moro-Sibilot D, Fallet V, Rabbe N, Thivolet-Bejui F, et al: c-MET overexpression as a poor predictor of MET amplifications or exon 14 mutations in lung sarcomatoid carcinomas. J Thorac Oncol. 13:1962–1967. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Ali G, Bruno R, Poma AM, Affinito O, Monticelli A, Piaggi P, Ricciardi S, Lucchi M, Melfi F, Chella A, et al: Whole transcriptome targeted gene quantification provides new insights on pulmonary sarcomatoid carcinomas. Sci Rep. 9:35362019. View Article : Google Scholar : PubMed/NCBI

4 

Roesel C, Kambartel K, Kopeika U, Berzins A, Voshaar T and Krbek T: Lazarus-type tumour response to therapy with nivolumab for sarcomatoid carcinomas of the lung. Curr Oncol. 26:e270–e273. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Manzotti G, Torricelli F, Benedetta D, Lococo F, Sancisi V, Rossi G, Piana S and Ciarrocchi A: An epithelial-to-mesenchymal transcriptional switch triggers evolution of pulmonary sarcomatoid carcinoma (PSC) and identifies dasatinib as new therapeutic option. Clin Cancer Res. 25:2348–2360. 2019. View Article : Google Scholar

6 

Tamaki T, Shimizu T, Niki M, Shimizu M, Nishizawa T and Nomura S: Immunohistochemical analysis of NANOG expression and epithelial-mesenchymal transition in pulmonary sarcomatoid carcinoma. Oncol Lett. 13:3695–3702. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Aiello NM and Kang Y: Context-dependent EMT programs in cancer metastasis. J Exp Med. 216:1016–1026. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Campbell K: Contribution of epithelial-mesenchymal transitions to organogenesis and cancer metastasis. Curr Opin Cell Biol. 55:30–35. 2018. View Article : Google Scholar : PubMed/NCBI

9 

van Staalduinen J, Baker D, Ten Dijke P and van Dam H: Epithelial-mesenchymal-transition-inducing transcription factors: New targets for tackling chemoresistance in cancer? Oncogene. 37:6195–6211. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Kalluri R: EMT: When epithelial cells decide to become mesenchymal-like cells. J Clin Invest. 119:1417–1419. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Duan L, Ye L, Zhuang L, Zou X, Liu S, Zhang Y, Zhang L, Jin C and Huang Y: VEGFC/VEGFR3 axis mediates TGFß1-induced epithelial-to-mesenchymal transition in non-small cell lung cancer cells. PLoS One. 13:e02004522018. View Article : Google Scholar

12 

Zhang F, Li T, Han L, Qin P, Wu Z, Xu B, Gao Q and Song Y: TGFß1-induced down-regulation of microRNA-138 contributes to epithelial-mesenchymal transition in primary lung cancer cells. Biochem Biophys Res Commun. 496:1169–1175. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Delgado-Bellido D, Serrano-Saenz S, Fernandez-Cortés M and Oliver FJ: Vasculogenic mimicry signaling revisited: Focus on non-vascular VE-cadherin. Mol Cancer. 16:652017. View Article : Google Scholar : PubMed/NCBI

14 

Guo Q, Yuan Y, Jin Z, Xu T, Gao Y, Wei H, Li C, Hou W and Hua B: Association between tumor vasculogenic mimicry and the poor prognosis of gastric cancer in China: An updated systematic review and meta-analysis. Biomed Res Int. 2016:24086452016. View Article : Google Scholar : PubMed/NCBI

15 

Qiao L, Liang N, Zhang J, Xie J, Liu F, Xu D, Yu X and Tian Y: Advanced research on vasculogenic mimicry in cancer. J Cell Mol Med. 19:315–326. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Wang HF, Wang SS, Zheng M, Dai LL, Wang K, Gao XL, Cao MX, Yu XH, Pang X, Zhang M, et al: Hypoxia promotes vasculogenic mimicry formation by vascular endothelial growth factor A mediating epithelial-mesenchymal transition in salivary adenoid cystic carcinoma. Cell Prolif. 52:e126002019. View Article : Google Scholar : PubMed/NCBI

17 

Ou H, Chen Z, Xiang L, Fang Y, Xu Y, Liu Q, Hu Z, Li X, Huang Y and Yang D: Frizzled 2-induced epithelial-mesenchymal transition correlates with vasculogenic mimicry, stemness, and Hippo signaling in hepatocellular carcinoma. Cancer Sci. 110:1169–1182. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Liu T, Sun B, Zhao X, Li Y, Zhao X, Liu Y, Yao Z, Gu Q, Dong X, Shao B, et al: USP44+ cancer stem cell subclones contribute to breast cancer aggressiveness by promoting vasculogenic mimicry. Mol Cancer Ther. 14:2121–2131. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Sun D, Sun B, Liu T, Zhao X, Che N, Gu Q, Dong X, Yao Z, Li R, Li J, et al: Slug promoted vasculogenic mimicry in hepatocellular carcinoma. J Cell Mol Med. 17:1038–1047. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Ding X, Li F and Zhang L: Knockdown of delta-like 3 restricts lipopolysaccharide-induced inflammation, migration and invasion of A2058 melanoma cells via blocking Twist1-mediated epithelial-mesenchymal transition. Life Sci. 226:149–155. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Ren H, Du P, Ge Z, Jin Y, Ding D, Liu X and Zou Q: TWIST1 and BMI1 in cancer metastasis and chemoresistance. J Cancer. 7:1074–1080. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Zhu QQ, Ma C, Wang Q, Song Y and Lv T: The role of TWIST1 in epithelial-mesenchymal transition and cancers. Tumour Biol. 37:185–197. 2016. View Article : Google Scholar

23 

Sun T, Sun BC, Zhao XL, Zhao N, Dong XY, Che N, Yao Z, Ma YM, Gu Q, Zong WK and Liu ZY: Promotion of tumor cell metastasis and vasculogenic mimicry by way of transcription coactivation by Bcl-2 and Twist1: A study of hepatocellular carcinoma. Hepatology. 54:1690–1706. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Sun T, Zhao N, Zhao XL, Gu Q, Zhang SW, Che N, Wang XH, Du J, Liu YX and Sun BC: Expression and functional significance of Twist1 in hepatocellular carcinoma: Its role in vasculogenic mimicry. Hepatology. 51:545–556. 2010. View Article : Google Scholar

25 

Yochum ZA, Cades J, Wang H, Chatterjee S, Simons BW, O'Brien JP, Khetarpal SK, Lemtiri-Chlieh G, Myers KV, Huang EH, et al: Targeting the EMT transcription factor TWIST1 overcomes resistance to EGFR inhibitors in EGFR-mutant non-small-cell lung cancer. Oncogene. 38:656–670. 2019. View Article : Google Scholar

26 

Sun H, Liu T, Zhu D, Dong X, Liu F, Liang X, Chen C, Shao B, Wang M and Wang Y: HnRNPM and CD44s expression affects tumor aggressiveness and predicts poor prognosis in breast cancer with axillary lymph node metastases. Genes Chromosomes Cancer. 56:598–607. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Wang Y, Sun H, Zhang D, Fan D, Zhang Y, Dong X, Liu S, Yang Z, Ni C, Li Y, et al: TP53INP1 inhibits hypoxia-induced vasculogenic mimicry formation via the ROS/snail signalling axis in breast cancer. J Cell Mol Med. 22:3475–3488. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Zhang H, Chen R, Yang S, Liu W, Li K, Zhang H, Zhu X and Chen B: Lobaplatin for the treatment of sk-mes-1 lung squamous cell line in vitro and in vivo. OncoTargets Ther. 9:4215–4224. 2016. View Article : Google Scholar

29 

Franks TJ and Galvin JR: Sarcomatoid carcinoma of the lung: Histologic criteria and common lesions in the differential diagnosis. Arch Pathol Lab Med. 134:49–54. 2010.PubMed/NCBI

30 

Dacic S, Finkelstein SD, Sasatomi E, Swalsky PA and Yousem SA: Molecular pathogenesis of pulmonary carcinosarcoma as determined by microdissection-based allelotyping. Am J Surg Pathol. 26:510–516. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Holst VA, Finkelstein S, Colby TV, Myers JL and Yousem SA: p53 and K-ras mutational genotyping in pulmonary carcinosarcoma, spindle cell carcinoma, and pulmonary blastoma: Implications for histogenesis. Am J Surg Pathol. 21:801–811. 1997. View Article : Google Scholar : PubMed/NCBI

32 

Chaffer CL, San Juan BP, Lim E and Weinberg RA: EMT, cell plasticity and metastasis. Cancer Metastasis Rev. 35:645–654. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Zhao Z, Rahman MA, Chen ZG and Shin DM: Multiple biological functions of Twist1 in various cancers. Oncotarget. 8:20380–20393. 2017.PubMed/NCBI

34 

Li Y, Sun B, Zhao X, Wang X, Zhang D, Gu Q and Liu T: MMP-2 and MMP-13 affect vasculogenic mimicry formation in large cell lung cancer. J Cell Mol Med. 21:3741–3751. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Hess AR, Seftor EA, Gruman LM, Kinch MS, Seftor RE and Hendrix MJ: VE-cadherin regulates EphA2 in aggressive melanoma cells through a novel signaling pathway: Implications for vasculogenic mimicry. Cancer Biol Ther. 5:228–233. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Guo JQ, Zheng QH, Chen H, Chen L, Xu JB, Chen MY, Lu D, Wang ZH, Tong HF and Lin S: Ginsenoside Rg3 inhibition of vasculogenic mimicry in pancreatic cancer through downregulation of VEcadherin/EphA2/MMP9/MMP2 expression. Int J Oncol. 45:1065–1072. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Chen LX, He YJ, Zhao SZ, Wu JG, Wang JT, Zhu LM, Lin TT, Sun BC and Li XR: Inhibition of tumor growth and vasculogenic mimicry by curcumin through downregulation of the EphA2/PI3K/MMP pathway in a murine choroidal melanoma model. Cancer Biol Ther. 11:229–235. 2011. View Article : Google Scholar

38 

Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, Savagner P, Gitelman I, Richardson A and Weinberg RA: Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell. 117:927–939. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Fan XJ, Wan XB, Yang ZL, Fu XH, Huang Y, Chen DK, Song SX, Liu Q, Xiao HY, Wang L and Wang JP: Snail promotes lymph node metastasis and Twist enhances tumor deposit formation through epithelial-mesenchymal transition in colorectal cancer. Hum Pathol. 44:173–180. 2013. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Liu T, Zhao X, Zheng X, Zheng Y, Dong X, Zhao N, Liao S and Sun B: The EMT transcription factor, Twist1, as a novel therapeutic target for pulmonary sarcomatoid carcinomas. Int J Oncol 56: 750-760, 2020.
APA
Liu, T., Zhao, X., Zheng, X., Zheng, Y., Dong, X., Zhao, N. ... Sun, B. (2020). The EMT transcription factor, Twist1, as a novel therapeutic target for pulmonary sarcomatoid carcinomas. International Journal of Oncology, 56, 750-760. https://doi.org/10.3892/ijo.2020.4972
MLA
Liu, T., Zhao, X., Zheng, X., Zheng, Y., Dong, X., Zhao, N., Liao, S., Sun, B."The EMT transcription factor, Twist1, as a novel therapeutic target for pulmonary sarcomatoid carcinomas". International Journal of Oncology 56.3 (2020): 750-760.
Chicago
Liu, T., Zhao, X., Zheng, X., Zheng, Y., Dong, X., Zhao, N., Liao, S., Sun, B."The EMT transcription factor, Twist1, as a novel therapeutic target for pulmonary sarcomatoid carcinomas". International Journal of Oncology 56, no. 3 (2020): 750-760. https://doi.org/10.3892/ijo.2020.4972
Copy and paste a formatted citation
x
Spandidos Publications style
Liu T, Zhao X, Zheng X, Zheng Y, Dong X, Zhao N, Liao S and Sun B: The EMT transcription factor, Twist1, as a novel therapeutic target for pulmonary sarcomatoid carcinomas. Int J Oncol 56: 750-760, 2020.
APA
Liu, T., Zhao, X., Zheng, X., Zheng, Y., Dong, X., Zhao, N. ... Sun, B. (2020). The EMT transcription factor, Twist1, as a novel therapeutic target for pulmonary sarcomatoid carcinomas. International Journal of Oncology, 56, 750-760. https://doi.org/10.3892/ijo.2020.4972
MLA
Liu, T., Zhao, X., Zheng, X., Zheng, Y., Dong, X., Zhao, N., Liao, S., Sun, B."The EMT transcription factor, Twist1, as a novel therapeutic target for pulmonary sarcomatoid carcinomas". International Journal of Oncology 56.3 (2020): 750-760.
Chicago
Liu, T., Zhao, X., Zheng, X., Zheng, Y., Dong, X., Zhao, N., Liao, S., Sun, B."The EMT transcription factor, Twist1, as a novel therapeutic target for pulmonary sarcomatoid carcinomas". International Journal of Oncology 56, no. 3 (2020): 750-760. https://doi.org/10.3892/ijo.2020.4972
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