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Review

GSTP1 and cancer: Expression, methylation, polymorphisms and signaling (Review)

  • Authors:
    • Jian Cui
    • Guoqing Li
    • Jie Yin
    • Linwei Li
    • Yue Tan
    • Haoran Wei
    • Bang Liu
    • Lihong Deng
    • Jialu Tang
    • Yonglin Chen
    • Lan Yi
  • View Affiliations / Copyright

    Affiliations: Hengyang Medical College, Institute of Cytology and Genetics, Key Laboratory of Ecological Environment and Critical Human Diseases Prevention of Hunan Province Department of Education, University of South China, Hengyang, Hunan 421001, P.R. China, Department of Laboratory, The Second Affiliated Hospital, University of South China, Hengyang, Hunan 421001, P.R. China
  • Pages: 867-878
    |
    Published online on: February 10, 2020
       https://doi.org/10.3892/ijo.2020.4979
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Abstract

Glutathione S‑transferase Pi (GSTP1) is an isozyme encoded by the GST pi gene that plays an important regulatory role in detoxification, anti‑oxidative damage, and the occurrence of various diseases. The aim of the present study was to review the association between the expression of GSTP1 and the development and treatment of various cancers, and discuss GSTP1 methylation in several malignant tumors, such as prostate, breast and lung cancer, as well as hepatocellular carcinoma; to review the association between polymorphism of the GSTP1 gene and various diseases; and to review the effects of GSTP1 on electrophilic oxidative stress, cell signal transduction, and the regulation of carcinogenic factors. Collectively, GSTP1 plays a major role in the development of various diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Cui J, Li G, Yin J, Li L, Tan Y, Wei H, Liu B, Deng L, Tang J, Chen Y, Chen Y, et al: GSTP1 and cancer: Expression, methylation, polymorphisms and signaling (Review). Int J Oncol 56: 867-878, 2020.
APA
Cui, J., Li, G., Yin, J., Li, L., Tan, Y., Wei, H. ... Yi, L. (2020). GSTP1 and cancer: Expression, methylation, polymorphisms and signaling (Review). International Journal of Oncology, 56, 867-878. https://doi.org/10.3892/ijo.2020.4979
MLA
Cui, J., Li, G., Yin, J., Li, L., Tan, Y., Wei, H., Liu, B., Deng, L., Tang, J., Chen, Y., Yi, L."GSTP1 and cancer: Expression, methylation, polymorphisms and signaling (Review)". International Journal of Oncology 56.4 (2020): 867-878.
Chicago
Cui, J., Li, G., Yin, J., Li, L., Tan, Y., Wei, H., Liu, B., Deng, L., Tang, J., Chen, Y., Yi, L."GSTP1 and cancer: Expression, methylation, polymorphisms and signaling (Review)". International Journal of Oncology 56, no. 4 (2020): 867-878. https://doi.org/10.3892/ijo.2020.4979
Copy and paste a formatted citation
x
Spandidos Publications style
Cui J, Li G, Yin J, Li L, Tan Y, Wei H, Liu B, Deng L, Tang J, Chen Y, Chen Y, et al: GSTP1 and cancer: Expression, methylation, polymorphisms and signaling (Review). Int J Oncol 56: 867-878, 2020.
APA
Cui, J., Li, G., Yin, J., Li, L., Tan, Y., Wei, H. ... Yi, L. (2020). GSTP1 and cancer: Expression, methylation, polymorphisms and signaling (Review). International Journal of Oncology, 56, 867-878. https://doi.org/10.3892/ijo.2020.4979
MLA
Cui, J., Li, G., Yin, J., Li, L., Tan, Y., Wei, H., Liu, B., Deng, L., Tang, J., Chen, Y., Yi, L."GSTP1 and cancer: Expression, methylation, polymorphisms and signaling (Review)". International Journal of Oncology 56.4 (2020): 867-878.
Chicago
Cui, J., Li, G., Yin, J., Li, L., Tan, Y., Wei, H., Liu, B., Deng, L., Tang, J., Chen, Y., Yi, L."GSTP1 and cancer: Expression, methylation, polymorphisms and signaling (Review)". International Journal of Oncology 56, no. 4 (2020): 867-878. https://doi.org/10.3892/ijo.2020.4979
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