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Review

Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review)

  • Authors:
    • Zhou Zhang
    • Lixia Zheng
    • Yang Yu
    • Jinying Wu
    • Fan Yang
    • Yingxi Xu
    • Qiqiang Guo
    • Xuan Wu
    • Sunrun Cao
    • Liu Cao
    • Xiaoyu Song
  • View Affiliations / Copyright

    Affiliations: College of Basic Medical Science, Institute of Translational Medicine, China Medical University, Shenyang, Liaoning 110122, P.R. China
  • Pages: 879-888
    |
    Published online on: February 14, 2020
       https://doi.org/10.3892/ijo.2020.4988
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Abstract

Sterile alpha motif and histidine/aspartic acid domain‑containing protein 1 (SAMHD1), the only deoxynucleotide triphosphate (dNTP) hydrolase in eukaryotes, plays a crucial role in regulating the dynamic balance and ratio of cellular dNTP pools. Furthermore, SAMHD1 has been reported to be involved in the pathological process of several diseases. Homozygous SAMHD1 mutations have been identified in immune system disorders, such as autoimmune disease Aicardi‑Goutières syndrome (AGS), whose primary pathogenesis is associated with the abnormal accumulation and disproportion of dNTPs. SAMHD1 is also considered to be an intrinsic virus‑restriction factor by suppressing the viral infection process, including reverse transcription, replication, packaging and transmission. In addition, SAMHD1 has been shown to promote genome integrity during homologous recombination following DNA damage, thus being considered a promising candidate for oncotherapy applications. The present review summarizes the molecular mechanisms of SAMHD1 regarding the regulation of dNTP homeostasis and DNA damage response. Additionally, its potential effects on tumorigenesis and oncotherapy are reported.
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1 

Kunz BA, Kohalmi SE, Kunkel TA, Mathews CK, McIntosh EM and Reidy JA: International commission for protection against environmental mutagens and carcinogens. Deoxyribonucleoside triphosphate levels: A critical factor in the maintenance of genetic stability. Mutat Res. 318:1–64. 1994. View Article : Google Scholar : PubMed/NCBI

2 

Reichard P: Interactions between deoxyribonucleotide and DNA synthesis. Annu Rev Biochem. 57:349–374. 1988. View Article : Google Scholar : PubMed/NCBI

3 

Lee EJ, Seo JH, Park JH, Vo TTL, An S, Bae SJ, Le H, Lee HS, Wee HJ, Lee D, et al: SAMHD1 acetylation enhances its deoxy-nucleotide triphosphohydrolase activity and promotes cancer cell proliferation. Oncotarget. 8:68517–68529. 2017.PubMed/NCBI

4 

Koharudin LM, Wu Y, DeLucia M, Mehrens J, Gronenborn AM and Ahn J: Structural basis of allosteric activation of sterile α motif and histidine-aspartate domain-containing protein 1 (SAMHD1) by nucleoside triphosphates. J Biol Chem. 289:32617–32627. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Welbourn S, Dutta SM, Semmes OJ and Strebel K: Restriction of virus infection but not catalytic dNTPase activity is regulated by phosphorylation of SAMHD1. J Virol. 87:11516–11524. 2013. View Article : Google Scholar : PubMed/NCBI

6 

White TE, Brandariz-Nunez A, Valle-Casuso JC, Amie S, Nguyen LA, Kim B, Tuzova M and Diaz-Griffero F: The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation. Cell Host Microbe. 13:441–451. 2013. View Article : Google Scholar : PubMed/NCBI

7 

St Gelais C, de Silva S, Hach JC, White TE, Diaz-Griffero F, Yount JS and Wu L: Identification of cellular proteins interacting with the retroviral restriction factor SAMHD1. J Virol. 88:5834–5844. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Ji X, Tang C, Zhao Q, Wang W and Xiong Y: Structural basis of cellular dNTP regulation by SAMHD1. Proc Natl Acad Sci USA. 111:E4305–E4314. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Zhang K, Lv DW and Li R: Conserved herpesvirus protein kinases target SAMHD1 to facilitate virus replication. Cell Rep. 28:449–459 e445. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Kim ET, Roche KL, Kulej K, Spruce LA, Seeholzer SH, Coen DM, Diaz-Griffero F, Murphy EA and Weitzman MD: SAMHD1 modulates early steps during human cytomegalovirus infection by limiting NF-kB activation. Cell Rep. 28:434–448 e436. 2019. View Article : Google Scholar

11 

de Silva S, Hoy H, Hake TS, Wong HK, Porcu P and Wu L: Promoter methylation regulates SAMHD1 gene expression in human CD4+ T cells. J Biol Chem. 288:9284–9292. 2013. View Article : Google Scholar : PubMed/NCBI

12 

de Silva S, Wang F, Hake TS, Porcu P, Wong HK and Wu L: Downregulation of SAMHD1 expression correlates with promoter DNA methylation in Sezary syndrome patients. J Invest Dermatol. 134:562–565. 2014. View Article : Google Scholar

13 

Wang JL, Lu FZ, Shen XY, Wu Y and Zhao LT: SAMHD1 is down regulated in lung cancer by methylation and inhibits tumor cell proliferation. Biochem Biophys Res Commun. 455:229–233. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Laguette N, Sobhian B, Casartelli N, Ringeard M, Chable-Bessia C, Ségéral E, Yatim A, Emiliani S, Schwartz O and Benkirane M: SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature. 474:654–657. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Hrecka K, Hao C, Gierszewska M, Swanson SK, Kesik-Brodacka M, Srivastava S, Florens L, Washburn MP and Skowronski J: Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature. 474:658–661. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Berger A, Sommer AF, Zwarg J, Hamdorf M, Welzel K, Esly N, Panitz S, Reuter A, Ramos I, Jatiani A, et al: SAMHD1-deficient CD14+ cells from individuals with aicardigoutieres syndrome are highly susceptible to HIV-1 infection. PLoS Pathog. 7:e10024252011. View Article : Google Scholar

17 

Ahn J, Hao C, Yan J, DeLucia M, Mehrens J, Wang C, Gronenborn AM and Skowronski J: HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1. J Biol Chem. 287:12550–12558. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Li N, Zhang W and Cao X: Identification of human homologue of mouse IFN-gamma induced protein from human dendritic cells. Immunol Lett. 74:221–224. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Kueck T, Cassella E, Holler J, Kim B and Bieniasz PD: The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression. Elife. 7:e388672018. View Article : Google Scholar : PubMed/NCBI

20 

Goldstone DC, Ennis-Adeniran V, Hedden JJ, Groom HC, Rice GI, Christodoulou E, Walker PA, Kelly G, Haire LF, Yap MW, et al: HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature. 480:379–382. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Leshinsky-Silver E, Malinger G, Ben-Sira L, Kidron D, Cohen S, Inbar S, Bezaleli T, Levine A, Vinkler C, Lev D and Lerman-Sagie T: A large homozygous deletion in the SAMHD1 gene causes atypical aicardi-goutieres syndrome associated with mtDNA deletions. Eur J Hum Genet. 19:287–292. 2011. View Article : Google Scholar

22 

Rice GI, Bond J, Asipu A, Brunette RL, Manfield IW, Carr IM, Fuller JC, Jackson RM, Lamb T, Briggs TA, et al: Mutations involved in aicardi-goutieres syndrome implicate SAMHD1 as regulator of the innate immune response. Nat Genet. 41:829–832. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Thiele H, du Moulin M, Barczyk K, George C, Schwindt W, Nürnberg G, Frosch M, Kurlemann G, Roth J, Nürnberg P and Rutsch F: Cerebral arterial stenoses and stroke: Novel features of Aicardi-Goutieres syndrome caused by the arg164X mutation in SAMHD1 are associated with altered cytokine expression. Hum Mutat. 31:E1836–E1850. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Dale RC, Gornall H, Singh-Grewal D, Alcausin M, Rice GI and Crow YJ: Familial aicardi-goutieres syndrome due to SAMHD1 mutations is associated with chronic arthropathy and contractures. Am J Med Genet A. 152A:938–942. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Brandariz-Nunez A, Valle-Casuso JC, White TE, Laguette N, Benkirane M, Brojatsch J and Diaz-Griffero F: Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac. Retrovirology. 9:492012. View Article : Google Scholar : PubMed/NCBI

26 

Hofmann H, Logue EC, Bloch N, Daddacha W, Polsky SB, Schultz ML, Kim B and Landau NR: The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus. J Virol. 86:12552–12560. 2012. View Article : Google Scholar : PubMed/NCBI

27 

DeLucia M, Mehrens J, Wu Y and Ahn J: HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation. J Biol Chem. 288:19116–19126. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Kim CA and Bowie JU: SAM domains: Uniform structure, diversity of function. Trends Biochem Sci. 28:625–628. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Laguette N and Benkirane M: How SAMHD1 changes our view of viral restriction. Trends Immunol. 33:26–33. 2012. View Article : Google Scholar

30 

Antonucci JM, St Gelais C, de Silva S, Yount JS, Tang C, Ji X, Shepard C, Xiong Y, Kim B and Wu L: SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activity. Nat Med. 22:1072–1074. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Ryoo J, Choi J, Oh C, Kim S, Seo M, Kim SY, Seo D, Kim J, White TE, Brandariz-Nuñez A, et al: The ribonuclease activity of SAMHD1 is required for HIV-1 restriction. Nat Med. 20:936–941. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Zhu CF, Wei W, Peng X, Dong YH, Gong Y and Yu XF: The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP. Acta Crystallogr D Biol Crystallogr. 71:516–524. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Li Y, Kong J, Peng X, Hou W, Qin X and Yu XF: Structural insights into the high-efficiency catalytic mechanism of the sterile α-motif/histidine-aspartate domain-containing protein. J Biol Chem. 290:29428–29437. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Patra KK, Bhattacharya A and Bhattacharya S: Allosteric signal transduction in HIV-1 restriction factor SAMHD1 proceeds via reciprocal handshake across monomers. J Chem Inf Model. 57:2523–2538. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Yan J, Kaur S, DeLucia M, Hao C, Mehrens J, Wang C, Golczak M, Palczewski K, Gronenborn AM, Ahn J and Skowronski J: Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection. J Biol Chem. 288:10406–10417. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Mauney CH, Rogers LC, Harris RS, Daniel LW, Devarie-Baez NO, Wu H, Furdui CM, Poole LB, Perrino FW and Hollis T: The SAMHD1 dNTP triphosphohydrolase is controlled by a redox switch. Antioxid Redox Signal. 27:1317–1331. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Mauney CH and Hollis T: SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity. Autoimmunity. 51:96–110. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Tramentozzi E, Ferraro P, Hossain M, Stillman B, Bianchi V and Pontarin G: The dNTP triphosphohydrolase activity of SAMHD1 persists during S-phase when the enzyme is phosphorylated at T592. Cell Cycle. 17:1102–1114. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Arnold LH, Groom HC, Kunzelmann S, Schwefel D, Caswell SJ, Ordonez P, Mann MC, Rueschenbaum S, Goldstone DC, Pennell S, et al: Phospho-dependent regulation of SAMHD1 oligomerisation couples catalysis and restriction. PLoS Pathog. 11:e10051942015. View Article : Google Scholar : PubMed/NCBI

40 

Ji X, Wu Y, Yan J, Mehrens J, Yang H, DeLucia M, Hao C, Gronenborn AM, Skowronski J, Ahn J and Xiong Y: Mechanism of allosteric activation of SAMHD1 by dGTP. Nat Struct Mol Biol. 20:1304–1309. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Badia R, Angulo G, Riveira-Munoz E, Pujantell M, Puig T, Ramirez C, Torres-Torronteras J, Martí R, Pauls E, Clotet B, et al: Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1. J Antimicrob Chemother. 71:387–394. 2016. View Article : Google Scholar :

42 

Kim ET, White TE, Brandariz-Nunez A, Diaz-Griffero F and Weitzman MD: SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication. J Virol. 87:12949–12956. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Hu J, Qiao M, Chen Y, Tang H, Zhang W, Tang D, Pi S, Dai J, Tang N, Huang A and Hu Y: Cyclin E2-CDK2 mediates SAMHD1 phosphorylation to abrogate its restriction of HBV replication in hepatoma cells. FEBS Lett. 592:1893–1904. 2018. View Article : Google Scholar : PubMed/NCBI

44 

Sommer AF, Riviere L, Qu B, Schott K, Riess M, Ni Y, Shepard C, Schnellbächer E, Finkernagel M, Himmelsbach K, et al: Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle. Sci Rep. 6:266162016. View Article : Google Scholar : PubMed/NCBI

45 

Li M, Zhang D, Zhu M, Shen Y, Wei W, Ying S, Korner H and Li J: Roles of SAMHD1 in antiviral defense, autoimmunity and cancer. Rev Med Virol. 27:2017. View Article : Google Scholar : PubMed/NCBI

46 

Cribier A, Descours B, Valadao AL, Laguette N and Benkirane M: Phosphorylation of SAMHD1 by Cyclin A2/CDK1 regulates its restriction activity toward HIV-1. Cell Rep. 3:1036–1043. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Pauls E, Ruiz A, Badia R, Permanyer M, Gubern A, Riveira-Muñoz E, Torres-Torronteras J, Alvarez M, Mothe B, Brander C, et al: Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells. J Immunol. 193:1988–1997. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Valle-Casuso JC, Allouch A, David A, Lenzi GM, Studdard L, Barré-Sinoussi F, Müller-Trutwin M, Kim B, Pancino G and Sáez-Cirión A: p21 Restricts HIV-1 in monocyte-derived dendritic cells through the reduction of deoxynucleoside triphos-phate biosynthesis and regulation of SAMHD1 antiviral activity. J Virol. 91:e01324–e01317. 2017. View Article : Google Scholar :

49 

Bloch N, O'Brien M, Norton TD, Polsky SB, Bhardwaj N and Landau NR: HIV type 1 infection of plasmacytoid and myeloid dendritic cells is restricted by high levels of SAMHD1 and cannot be counteracted by Vpx. AIDS Res Hum Retroviruses. 30:195–203. 2014. View Article : Google Scholar :

50 

Dragin L, Nguyen LA, Lahouassa H, Sourisce A, Kim B, Ramirez BC and Margottin-Goguet F: Interferon block to HIV-1 transduction in macrophages despite SAMHD1 degradation and high deoxynucleoside triphosphates supply. Retrovirology. 10:302013. View Article : Google Scholar : PubMed/NCBI

51 

Lafuse WP, Brown D, Castle L and Zwilling BS: Cloning and characterization of a novel cDNA that is IFN-gamma-induced in mouse peritoneal macrophages and encodes a putative GTP-binding protein. J Leukoc Biol. 57:477–483. 1995. View Article : Google Scholar : PubMed/NCBI

52 

Taylor GA, Jeffers M, Largaespada DA, Jenkins NA, Copeland NG and Vande Woude GF: Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma. J Biol Chem. 271:20399–20405. 1996. View Article : Google Scholar : PubMed/NCBI

53 

Szaniawski MA, Spivak AM, Cox JE, Catrow JL, Hanley T, Williams ESCP, Tremblay MJ, Bosque A and Planelles V: SAMHD1 phosphorylation coordinates the Anti-HIV-1 response by diverse interferons and tyrosine kinase inhibition. Mbio. 9:e00819–e00818. 2018. View Article : Google Scholar : PubMed/NCBI

54 

Tang C, Ji X, Wu L and Xiong Y: Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592. J Biol Chem. 290:26352–26359. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Schott K, Fuchs NV, Derua R, Mahboubi B, Schnellbächer E, Seifr ied J, Tondera C, Schm itz H, Shepa rd C, Brandariz-Nuñez A, et al: Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55 α holoenzymes during mitotic exit. Nat Commun. 9:22272018. View Article : Google Scholar

56 

Franzolin E, Pontarin G, Rampazzo C, Miazzi C, Ferraro P, Palumbo E, Reichard P and Bianchi V: The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells. Proc Natl Acad Sci USA. 110:14272–14277. 2013. View Article : Google Scholar : PubMed/NCBI

57 

Kretschmer S, Wolf C, Konig N, Staroske W, Guck J, Häusler M, Luksch H, Nguyen LA, Kim B, Alexopoulou D, et al: SAMHD1 prevents autoimmunity by maintaining genome stability. Ann Rheum Dis. 74:e172015. View Article : Google Scholar :

58 

Mathews CK: DNA precursor metabolism and genomic stability. FASEB J. 20:1300–1314. 2006. View Article : Google Scholar : PubMed/NCBI

59 

Poli J, Tsaponina O, Crabbe L, Keszthelyi A, Pantesco V, Chabes A, Lengronne A and Pasero P: dNTP pools determine fork progression and origin usage under replication stress. EMBO J. 31:883–894. 2012. View Article : Google Scholar : PubMed/NCBI

60 

Coquel F, Silva MJ, Techer H, Zadorozhny K, Sharma S, Nieminuszczy J, Mettling C, Dardillac E, Barthe A, Schmitz AL, et al: SAMHD1 acts at stalled replication forks to prevent interferon induction. Nature. 557:57–61. 2018. View Article : Google Scholar : PubMed/NCBI

61 

Seo YR, Sweeney C and Smith ML: Selenomethionine induction of DNA repair response in human fibroblasts. Oncogene. 21:3663–3669. 2002. View Article : Google Scholar : PubMed/NCBI

62 

Lin Y, Ha A and Yan S: Methods for studying DNA single-strand break repair and signaling in xenopus laevis egg extracts. Methods Mol Biol. 1999:161–172. 2019. View Article : Google Scholar : PubMed/NCBI

63 

Hanawalt PC: Historical perspective on the DNA damage response. DNA Repair (Amst). 36:2–7. 2015. View Article : Google Scholar

64 

Chu G: Double strand break repair. J Biol Chem. 272:24097–24100. 1997. View Article : Google Scholar : PubMed/NCBI

65 

Rooney S, Chaudhuri J and Alt FW: The role of the non-homologous end-joining pathway in lymphocyte development. Immunol Rev. 200:115–131. 2004. View Article : Google Scholar : PubMed/NCBI

66 

Figueroa-Gonzalez G and Perez-Plasencia C: Strategies for the evaluation of DNA damage and repair mechanisms in cancer. Oncol Lett. 13:3982–3988. 2017. View Article : Google Scholar : PubMed/NCBI

67 

Morio T: Recent advances in the study of immunodeficiency and DNA damage response. Int J Hematol. 106:357–365. 2017. View Article : Google Scholar : PubMed/NCBI

68 

Barzilai A: DNA damage, neuronal and glial cell death and neurodegeneration. Apoptosis. 15:1371–1381. 2010. View Article : Google Scholar : PubMed/NCBI

69 

Brown JS and Jackson SP: Ubiquitylation, neddylation and the DNA damage response. Open Biol. 5:1500182015. View Article : Google Scholar : PubMed/NCBI

70 

Medeiros AC, Soares CS, Coelho PO, Vieira NA, Baqui MMA, Teixeira FR and Gomes MD: DNA damage response signaling does not trigger redistribution of SAMHD1 to nuclear foci. Biochem Biophys Res Commun. 499:790–796. 2018. View Article : Google Scholar : PubMed/NCBI

71 

Cabello-Lobato MJ, Wang S and Schmidt CK: SAMHD1 sheds moonlight on DNA double-strand break repair. Trends Genet. 33:895–897. 2017. View Article : Google Scholar : PubMed/NCBI

72 

Clifford R, Louis T, Robbe P, Ackroyd S, Burns A, Timbs AT, Wright Colopy G, Dreau H, Sigaux F, Judde JG, et al: SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage. Blood. 123:1021–1031. 2014. View Article : Google Scholar :

73 

Oh C, Ryoo J, Park K, Kim B, Daly MB, Cho D and Ahn K: A central role for PI3K-AKT signaling pathway in linking SAMHD1-deficiency to the type I interferon signature. Sci Rep. 8:842018. View Article : Google Scholar : PubMed/NCBI

74 

Martinez-Lopez A, Martin-Fernandez M, Buta S, Kim B, Bogunovic D and Diaz-Griffero F: SAMHD1 deficient human monocytes autonomously trigger type I interferon. Mol Immunol. 101:450–460. 2018. View Article : Google Scholar : PubMed/NCBI

75 

Ramantani G, Kohlhase J, Hertzberg C, Innes AM, Engel K, Hunger S, Borozdin W, Mah JK, Ungerath K, Walkenhorst H, et al: Expanding the phenotypic spectrum of lupus erythematosus in aicardi-goutieres syndrome. Arthritis Rheum. 62:1469–1477. 2010. View Article : Google Scholar : PubMed/NCBI

76 

Aicardi J and Goutieres F: A progressive familial encephalopathy in infancy with calcifications of the basal ganglia and chronic cerebrospinal fluid lymphocytosis. Ann Neurol. 15:49–54. 1984. View Article : Google Scholar : PubMed/NCBI

77 

Pendergraft WF III and Means TK: AGS, SLE, and RNASEH2 mutations: Translating insights into therapeutic advances. J Clin Invest. 125:102–104. 2015. View Article : Google Scholar :

78 

Ramantani G, Hausler M, Niggemann P, Wessling B, Guttmann H, Mull M, Tenbrock K and Lee-Kirsch MA: Aicardi-Goutieres syndrome and systemic lupus erythematosus (SLE) in a 12-year-old boy with SAMHD1 mutations. J Child Neurol. 26:1425–1428. 2011. View Article : Google Scholar : PubMed/NCBI

79 

Hu WS and Hughes SH: HIV-1 reverse transcription. Cold Spring Harb Perspect Med. 2:a0068822012. View Article : Google Scholar : PubMed/NCBI

80 

Sarafianos SG, Marchand B, Das K, Himmel DM, Parniak MA, Hughes SH and Arnold E: Structure and function of HIV-1 reverse transcriptase: Molecular mechanisms of polymerization and inhibition. J Mol Biol. 385:693–713. 2009. View Article : Google Scholar

81 

Amie SM, Noble E and Kim B: Intracellular nucleotide levels and the control of retroviral infections. Virology. 436:247–254. 2013. View Article : Google Scholar :

82 

Traut TW: Physiological concentrations of purines and pyrimidines. Mol Cell Biochem. 140:1–22. 1994. View Article : Google Scholar : PubMed/NCBI

83 

Kennedy EM, Amie SM, Bambara RA and Kim B: Frequent incorporation of ribonucleotides during HIV-1 reverse transcription and their attenuated repair in macrophages. J Biol Chem. 287:14280–14288. 2012. View Article : Google Scholar : PubMed/NCBI

84 

Kennedy EM, Gavegnano C, Nguyen L, Slater R, Lucas A, Fromentin E, Schinazi RF and Kim B: Ribonucleoside triphosphates as substrate of human immunodeficiency virus type 1 reverse transcriptase in human macrophages. J Biol Chem. 285:39380–39391. 2010. View Article : Google Scholar : PubMed/NCBI

85 

Antonucci JM, Kim SH, St Gelais C, Bonifati S, Li TW, Buzovetsky O, Knecht KM, Duchon AA, Xiong Y, Musier-Forsyth K and Wu L: SAMHD1 impairs HIV-1 gene expression and negatively modulates reactivation of viral latency in CD4(+) T cells. J Virol. 92:e00292–e00218. 2018. View Article : Google Scholar :

86 

Gao W, Li G, Bian X, Rui Y, Zhai C, Liu P, Su J, Wang H, Zhu C, Du Y, et al: Defective modulation of LINE-1 retrotransposition by cancer-associated SAMHD1 mutants. Biochem Biophys Res Commun. 519:213–219. 2019. View Article : Google Scholar : PubMed/NCBI

87 

Maelfait J, Bridgeman A, Benlahrech A, Cursi C and Rehwinkel J: Restriction by SAMHD1 limits cGAS/STING-dependent innate and adaptive immune responses to HIV-1. Cell Rep. 16:1492–1501. 2016. View Article : Google Scholar : PubMed/NCBI

88 

Baldauf HM, Stegmann L, Schwarz SM, Ambiel I, Trotard M, Martin M, Burggraf M, Lenzi GM, Lejk H, Pan X, et al: Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells. Proc Natl Acad Sci USA. 114:2729–2734. 2017. View Article : Google Scholar : PubMed/NCBI

89 

Miyakawa K, Matsunaga S, Yokoyama M, Nomaguchi M, Kimura Y, Nishi M, Kimura H, Sato H, Hirano H, Tamura T, et al: PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation. Nat Commun. 10:18442019. View Article : Google Scholar : PubMed/NCBI

90 

Yurkovetskiy L, Guney MH, Kim K, Goh SL, McCauley S, Dauphin A, Diehl WE and Luban J: Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex. Nat Microbiol. 3:1354–1361. 2018. View Article : Google Scholar : PubMed/NCBI

91 

Reinhard C, Bottinelli D, Kim B and Luban J: Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration. Retrovirology. 11:122014. View Article : Google Scholar : PubMed/NCBI

92 

White TE, Brandariz-Nunez A, Valle-Casuso JC, Amie S, Nguyen L, Kim B, Brojatsch J and Diaz-Griffero F: Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1. Virology. 436:81–90. 2013. View Article : Google Scholar :

93 

Rossi D: SAMHD1: A new gene for CLL. Blood. 123:951–952. 2014. View Article : Google Scholar : PubMed/NCBI

94 

Rentoft M, Lindell K, Tran P, Chabes AL, Buckland RJ, Watt DL, Marjavaara L, Nilsson AK, Melin B, Trygg J, et al: Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance. Proc Natl Acad Sci USA. 113:4723–4728. 2016. View Article : Google Scholar : PubMed/NCBI

95 

Kodigepalli KM, Li MH, Liu SL and Wu L: Exogenous expression of SAMHD1 inhibits proliferation and induces apoptosis in cutaneous T-cell lymphoma-derived HuT78 cells. Cell Cycle. 16:179–188. 2017. View Article : Google Scholar :

96 

Contassot E, Kerl K, Roques S, Shane R, Gaide O, Dupuis M, Rook AH and French LE: Resistance to FasL and tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in Sezary syndrome T-cells associated with impaired death receptor and FLICE-inhibitory protein expression. Blood. 111:4780–4787. 2008. View Article : Google Scholar : PubMed/NCBI

97 

Zhang CL, Kamarashev J, Qin JZ, Burg G, Dummer R and Dobbeling U: Expression of apoptosis regulators in cutaneous T-cell lymphoma (CTCL) cells. J Pathol. 200:249–254. 2003. View Article : Google Scholar : PubMed/NCBI

98 

Forbes SA, Beare D, Boutselakis H, Bamford S, Bindal N, Tate J, Cole CG, Ward S, Dawson E, Ponting L, et al: COSMIC: Somatic cancer genetics at high-resolution. Nucleic Acids Res. 45:D777–D783. 2017. View Article : Google Scholar :

99 

Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, et al: The consensus coding sequences of human breast and colorectal cancers. Science. 314:268–274. 2006. View Article : Google Scholar : PubMed/NCBI

100 

Kohnken R, Kodigepalli KM, Mishra A, Porcu P and Wu L: MicroRNA-181 contributes to downregulation of SAMHD1 expression in CD4+T-cells derived from Sezary syndrome patients. Leuk Res. 52:58–66. 2017. View Article : Google Scholar

101 

Liu J, Lee W, Jiang Z, Chen Z, Jhunjhunwala S, Haverty PM, Gnad F, Guan Y, Gilbert HN, Stinson J, et al: Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events. Genome Res. 22:2315–2327. 2012. View Article : Google Scholar : PubMed/NCBI

102 

Shang Z, Qian L, Liu S, Niu X, Qiao Z, Sun Y, Zhang Y, Fan LY, Guan X, Cao CX and Xiao H: Graphene oxide-facilitated comprehensive analysis of cellular nucleic acid binding proteins for lung cancer. Acs Appl Mater Interfaces. 10:17756–17770. 2018. View Article : Google Scholar : PubMed/NCBI

103 

Yang CA, Huang HY, Chang YS, Lin CL, Lai IL and Chang JG: DNA-sensing and nuclease gene expressions as markers for colorectal cancer progression. Oncology. 92:115–124. 2017. View Article : Google Scholar

104 

Herrmann A, Wittmann S, Thomas D, Shepard CN, Kim B, Ferreirós N and Gramberg T: The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation. Mob DNA. 9:112018. View Article : Google Scholar : PubMed/NCBI

105 

Kohnken R, Kodigepalli KM and Wu L: Regulation of deoxy-nucleotide metabolism in cancer: Novel mechanisms and therapeutic implications. Mol Cancer. 14:1762015. View Article : Google Scholar

106 

Herold N, Rudd SG, Sanjiv K, Kutzner J, Bladh J, Paulin CBJ, Helleday T, Henter JI and Schaller T: SAMHD1 protects cancer cells from various nucleoside-based antimetabolites. Cell Cycle. 16:1029–1038. 2017. View Article : Google Scholar : PubMed/NCBI

107 

Rudd SG, Schaller T and Herold N: SAMHD1 is a barrier to antimetabolite-based cancer therapies. Mol Cell Oncol. 4:e12875542017. View Article : Google Scholar : PubMed/NCBI

108 

Zhu KW, Chen P, Zhang DY, Yan H, Liu H, Cen LN, Liu YL, Cao S, Zhou G, Zeng H, et al: Association of genetic polymorphisms in genes involved in Ara-C and dNTP metabolism pathway with chemosensitivity and prognosis of adult acute myeloid leukemia (AML). J Transl Med. 16:902018. View Article : Google Scholar : PubMed/NCBI

109 

Schneider C, Oellerich T, Baldauf HM, Schwarz SM, Thomas D, Flick R, Bohnenberger H, Kaderali L, Stegmann L, Cremer A, et al: SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia. Nat Med. 23:250–255. 2017. View Article : Google Scholar

110 

Ossenkoppele G and Lowenberg B: How I treat the older patient with acute myeloid leukemia. Blood. 125:767–774. 2015. View Article : Google Scholar

111 

Arnold LH, Kunzelmann S, Webb MR and Taylor IA: A continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction factor SAMHD1. Antimicrob Agents Chemother. 59:186–192. 2015. View Article : Google Scholar :

112 

Seamon KJ and Stivers JT: A high-throughput enzyme-coupled assay for SAMHD1 dNTPase. J Biomol Screen. 20:801–809. 2015. View Article : Google Scholar : PubMed/NCBI

113 

Baldauf HM, Pan X, Erikson E, Schmidt S, Daddacha W, Burggraf M, Schenkova K, Ambiel I, Wabnitz G, Gramberg T, et al: SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells. Nat Med. 18:1682–1687. 2012. View Article : Google Scholar : PubMed/NCBI

114 

Descours B, Cribier A, Chable-Bessia C, Ayinde D, Rice G, Crow Y, Yatim A, Schwartz O, Laguette N and Benkirane M: SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells. Retrovirology. 9:872012. View Article : Google Scholar : PubMed/NCBI

115 

Lahouassa H, Daddacha W, Hofmann H, Ayinde D, Logue EC, Dragin L, Bloch N, Maudet C, Bertrand M, Gramberg T, et al: SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleo-side triphosphates. Nat Immunol. 13:223–228. 2012. View Article : Google Scholar : PubMed/NCBI

116 

Sakai Y, Doi N, Miyazaki Y, Adachi A and Nomaguchi M: Phylogenetic insights into the functional relationship between primate lentiviral reverse transcriptase and accessory proteins vpx/vpr. Front Microbiol. 7:16552016. View Article : Google Scholar : PubMed/NCBI

117 

Plitnik T, Sharkey ME, Mahboubi B, Kim B and Stevenson M: Incomplete suppression of hiv-1 by samhd1 permits efficient macrophage infection. Pathog Immun. 3:197–223. 2018. View Article : Google Scholar

118 

Mereby SA, Maehigashi T, Holler JM, Kim DH, Schinazi RF and Kim B: Interplay of ancestral non-primate lentiviruses with the virus-restricting SAMHD1 proteins of their hosts. J Biol Chem. 293:16402–16412. 2018. View Article : Google Scholar : PubMed/NCBI

119 

Wang Z, Bhattacharya A, Villacorta J, Diaz-Griffero F and Ivanov DN: Allosteric activation of SAMHD1 protein by deoxynucleotide triphosphate (dNTP)-dependent tetramerization requires dNTP concentrations that are similar to dNTP concentrations observed in cycling T cells. J Biol Chem. 291:21407–21413. 2016. View Article : Google Scholar : PubMed/NCBI

120 

Bonifati S, Daly MB, St Gelais C, Kim SH, Hollenbaugh JA, Shepard C, Kennedy EM, Kim DH, Schinazi RF, Kim B and Wu L: SAMHD1 controls cell cycle status, apoptosis and HIV-1 infection in monocytic THP-1 cells. Virology. 495:92–100. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Zheng L, Yu Y, Wu J, Yang F, Xu Y, Guo Q, Wu X, Cao S, Cao L, Cao L, et al: Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review). Int J Oncol 56: 879-888, 2020.
APA
Zhang, Z., Zheng, L., Yu, Y., Wu, J., Yang, F., Xu, Y. ... Song, X. (2020). Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review). International Journal of Oncology, 56, 879-888. https://doi.org/10.3892/ijo.2020.4988
MLA
Zhang, Z., Zheng, L., Yu, Y., Wu, J., Yang, F., Xu, Y., Guo, Q., Wu, X., Cao, S., Cao, L., Song, X."Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review)". International Journal of Oncology 56.4 (2020): 879-888.
Chicago
Zhang, Z., Zheng, L., Yu, Y., Wu, J., Yang, F., Xu, Y., Guo, Q., Wu, X., Cao, S., Cao, L., Song, X."Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review)". International Journal of Oncology 56, no. 4 (2020): 879-888. https://doi.org/10.3892/ijo.2020.4988
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Zheng L, Yu Y, Wu J, Yang F, Xu Y, Guo Q, Wu X, Cao S, Cao L, Cao L, et al: Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review). Int J Oncol 56: 879-888, 2020.
APA
Zhang, Z., Zheng, L., Yu, Y., Wu, J., Yang, F., Xu, Y. ... Song, X. (2020). Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review). International Journal of Oncology, 56, 879-888. https://doi.org/10.3892/ijo.2020.4988
MLA
Zhang, Z., Zheng, L., Yu, Y., Wu, J., Yang, F., Xu, Y., Guo, Q., Wu, X., Cao, S., Cao, L., Song, X."Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review)". International Journal of Oncology 56.4 (2020): 879-888.
Chicago
Zhang, Z., Zheng, L., Yu, Y., Wu, J., Yang, F., Xu, Y., Guo, Q., Wu, X., Cao, S., Cao, L., Song, X."Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review)". International Journal of Oncology 56, no. 4 (2020): 879-888. https://doi.org/10.3892/ijo.2020.4988
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