Open Access

Cutaneous melanoma dissemination is dependent on the malignant cell properties and factors of intercellular crosstalk in the cancer microenvironment (Review)

  • Authors:
    • Ondřej Kodet
    • Jan Kučera
    • Karolína Strnadová
    • Barbora  Dvořánková
    • Jiří Štork
    • Lukáš Lacina
    • Karel Smetana
  • View Affiliations

  • Published online on: June 26, 2020     https://doi.org/10.3892/ijo.2020.5090
  • Copyright: © Kodet et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The incidence of cutaneous malignant melanoma has been steadily increasing worldwide for several decades. This phenomenon seems to follow the trend observed in many types of malignancies caused by multiple significant factors, including ageing. Despite the progress in cutaneous malignant melanoma therapeutic options, the curability of advanced disease after metastasis represents a serious challenge for further research. In this review, we summarise data on the microenvironment of cutaneous malignant melanoma with emphasis on intercellular signalling during the disease progression. Malignant melanocytes with features of neural crest stem cells interact with non‑malignant populations within this microenvironment. We focus on representative bioactive factors regulating this intercellular crosstalk. We describe the possible key factors and signalling cascades responsible for the high complexity of the melanoma microenvironment and its premetastatic niches. Furthermore, we present the concept of melanoma early becoming a systemic disease. This systemic effect is presented as a background for the new horizons in the therapy of cutaneous melanoma.

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Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Kodet O, Kučera J, Strnadová K, Dvořánková B, Štork J, Lacina L and Smetana K: Cutaneous melanoma dissemination is dependent on the malignant cell properties and factors of intercellular crosstalk in the cancer microenvironment (Review). Int J Oncol 0: 0-0, 1899
APA
Kodet, O., Kučera, J., Strnadová, K., Dvořánková, B., Štork, J., Lacina, L., & Smetana, K. (1899). Cutaneous melanoma dissemination is dependent on the malignant cell properties and factors of intercellular crosstalk in the cancer microenvironment (Review). International Journal of Oncology, 0, 0-0. https://doi.org/10.3892/ijo.2020.5090
MLA
Kodet, O., Kučera, J., Strnadová, K., Dvořánková, B., Štork, J., Lacina, L., Smetana, K."Cutaneous melanoma dissemination is dependent on the malignant cell properties and factors of intercellular crosstalk in the cancer microenvironment (Review)". International Journal of Oncology 0.0 (1899): 0-0.
Chicago
Kodet, O., Kučera, J., Strnadová, K., Dvořánková, B., Štork, J., Lacina, L., Smetana, K."Cutaneous melanoma dissemination is dependent on the malignant cell properties and factors of intercellular crosstalk in the cancer microenvironment (Review)". International Journal of Oncology 0, no. 0 (1899): 0-0. https://doi.org/10.3892/ijo.2020.5090