Open Access

Triple‑negative breast cancer therapy: Current and future perspectives (Review)

  • Authors:
    • Kwang‑Ai Won
    • Charles Spruck
  • View Affiliations

  • Published online on: October 16, 2020     https://doi.org/10.3892/ijo.2020.5135
  • Copyright: © Won et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Triple‑negative breast cancer (TNBC) accounts for 10‑15% of all breast cancer cases. TNBCs lack estrogen and progesterone receptors and express low levels of HER2, and therefore do not respond to hormonal or anti‑HER2 therapies. TNBC is a particularly aggressive form of breast cancer that generally displays poorer prognosis compared to other breast cancer subtypes. TNBC is chemotherapy sensitive, and this treatment remains the standard of care despite its limited benefit. Recent advances with novel agents have been made for specific subgroups with PD‑L1+ tumors or germline Brca‑mutated tumors. However, only a fraction of these patients responds to immune checkpoint or PARP inhibitors and even those who do respond often develop resistance and relapse. Various new agents and combination strategies have been explored to further understand molecular and immunological aspects of TNBC. In this review, we discuss clinical trials in the management of TNBC as well as perspectives for potential future treatments.

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Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Won KA and Won KA: Triple‑negative breast cancer therapy: Current and future perspectives (Review). Int J Oncol 0: 0-0, 1899
APA
Won, K., & Won, K. (1899). Triple‑negative breast cancer therapy: Current and future perspectives (Review). International Journal of Oncology, 0, 0-0. https://doi.org/10.3892/ijo.2020.5135
MLA
Won, K., Spruck, C."Triple‑negative breast cancer therapy: Current and future perspectives (Review)". International Journal of Oncology 0.0 (1899): 0-0.
Chicago
Won, K., Spruck, C."Triple‑negative breast cancer therapy: Current and future perspectives (Review)". International Journal of Oncology 0, no. 0 (1899): 0-0. https://doi.org/10.3892/ijo.2020.5135