The role of non‑coding RNAs in the regulation, diagnosis, prognosis and treatment of osteosarcoma (Review)

  • Authors:
    • Gu Yang
    • Yanjiao Wu
    • Rongxue Wan
    • Hongxun Sang
    • Huan Liu
    • Wenhua Huang
  • View Affiliations

  • Published online on: July 22, 2021     https://doi.org/10.3892/ijo.2021.5249
  • Article Number: 69
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Abstract

Osteosarcoma (OS) is the most common primary bone tumor worldwide. OS exhibits a range of aggressive behaviors, including early metastasis potential, rapid progression, poor clinical prognosis and insensitivity to chemoradiotherapy. Non‑coding RNAs are transcripts that do not encode proteins. A significant number of studies published on OS have been focused on the aberrant expression of non‑coding RNAs and their involvement in tumor initiation and progression. It has been confirmed that non‑coding RNAs exert their regulatory functions at both the transcriptional and post‑transcriptional level, which leads to tumor initiation or progression in OS. According to present knowledge, this review provides a state‑of‑the‑art overview of the functions and mechanisms of microRNAs, long non‑coding RNAs and circular RNAs in terms of their involvement with OS. The review also covers their potential clinical application in the diagnosis, prognosis and treatment of OS. It is hoped that the information presented in this review on the involvement of non‑coding RNAs in OS will lead to a more comprehensive understanding of OS and provide a useful perspective on the potential diagnostic and therapeutic applications of non‑coding RNAs for patients with OS.
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September-2021
Volume 59 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Yang G, Wu Y, Wan R, Sang H, Liu H and Huang W: The role of non‑coding RNAs in the regulation, diagnosis, prognosis and treatment of osteosarcoma (Review). Int J Oncol 59: 69, 2021
APA
Yang, G., Wu, Y., Wan, R., Sang, H., Liu, H., & Huang, W. (2021). The role of non‑coding RNAs in the regulation, diagnosis, prognosis and treatment of osteosarcoma (Review). International Journal of Oncology, 59, 69. https://doi.org/10.3892/ijo.2021.5249
MLA
Yang, G., Wu, Y., Wan, R., Sang, H., Liu, H., Huang, W."The role of non‑coding RNAs in the regulation, diagnosis, prognosis and treatment of osteosarcoma (Review)". International Journal of Oncology 59.3 (2021): 69.
Chicago
Yang, G., Wu, Y., Wan, R., Sang, H., Liu, H., Huang, W."The role of non‑coding RNAs in the regulation, diagnosis, prognosis and treatment of osteosarcoma (Review)". International Journal of Oncology 59, no. 3 (2021): 69. https://doi.org/10.3892/ijo.2021.5249