|
1
|
Herbst RS, Morgensztern D and Boshoff C:
The biology and management of non-small cell lung cancer. Nature.
553:446–454. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Miller KD, Nogueira L, Mariotto AB,
Rowland JH, Yabroff KR, Alfano CM, Jemal A, Kramer JL and Siegel
RL: Cancer treatment and survivorship statistics, 2019. CA Cancer J
Clin. 69:363–385. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Ercetin E, Richtmann S, Delgado BM,
Gomez-Mariano G, Wrenger S, Korenbaum E, Liu B, DeLuca D, Kuhnel
MP, Jonigk D, et al: Clinical significance of SERPINA1 gene and its
encoded Alpha1-antitrypsin protein in NSCLC. Cancers (Basel).
11:13062019. View Article : Google Scholar
|
|
4
|
Azouz NP, Klingler AM, Callahan V,
Akhrymuk IV, Elez K, Raich L, Henry BM, Benoit JL, Benoit SW, Noé
F, et al: Alpha 1 antitrypsin is an inhibitor of the
SARS-CoV-2-priming protease TMPRSS2. Pathog Immun. 6:55–74. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Wettstein L, Conzelmann C, Müller JA, Weil
T, Groß R, Hirschenberger M, Seidel A, Klute S, Zech F, Bozzo CP,
et al: Alpha-1 antitrypsin inhibits SARS-CoV-2 infection. bioRxiv.
2020.
|
|
6
|
Gupta S, Hayek SS, Wang W, Chan L, Mathews
KS, Melamed ML, Brenner SK, Leonberg-Yoo A, Schenck EJ, Radbel J,
et al: Factors associated with death in critically Ill patients
with coronavirus disease 2019 in the US. JAMA Intern Med.
180:1436–1447. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Derosa L, Melenotte C, Griscelli F, Gachot
B, Marabelle A, Kroemer G and Zitvogel L: The immuno-oncological
challenge of COVID-19. Nat Cancer. 1:946–964. 2020. View Article : Google Scholar
|
|
8
|
Sacconi A, Donzelli S, Pulito C, Ferrero
S, Spinella F, Morrone A, Rigoni M, Pimpinelli F, Ensoli F,
Sanguineti G, et al: TMPRSS2, a SARS-CoV-2 internalization protease
is downregulated in head and neck cancer patients. J Exp Clin
Cancer Res. 39:2002020. View Article : Google Scholar
|
|
9
|
Iwata-Yoshikawa N, Okamura T, Shimizu Y,
Hasegawa H, Takeda M and Nagata N: TMPRSS2 contributes to virus
spread and immunopathology in the airways of murine models after
coronavirus infection. J Virol. 93:e01815–e01818. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Clinckemalie L, Spans L, Dubois V, Laurent
M, Helsen C, Joniau S and Claessens F: Androgen regulation of the
TMPRSS2 gene and the effect of a SNP in an androgen response
element. Mol Endocrinol. 27:2028–2040. 2013. View Article : Google Scholar
|
|
11
|
Leach DA, Mohr A, Giotis ES, Cil E, Isac
AM, Yates LL, Barclay WS, Zwacka RM, Bevan CL and Brooke GN: The
antiandrogen enzalutamide downregulates TMPRSS2 and reduces
cellular entry of SARS-CoV-2 in human lung cells. Nat Commun.
12:40682021. View Article : Google Scholar
|
|
12
|
Wilson S, Greer B, Hooper J, Zijlstra A,
Walker B, Quigley J and Hawthorne S: The membrane-anchored serine
protease, TMPRSS2, activates PAR-2 in prostate cancer cells.
Biochem J. 388:967–972. 2005. View Article : Google Scholar :
|
|
13
|
Lam DK, Dang D, Flynn AN, Hardt M and
Schmidt BL: TMPRSS2, a novel membrane-anchored mediator in cancer
pain. Pain. 156:923–930. 2015. View Article : Google Scholar
|
|
14
|
Jairaman A, Yamashita M, Schleimer RP and
Prakriya M: Store-operated Ca2+ release-activated
Ca2+ channels regulate PAR2-activated Ca2+
signaling and cytokine production in airway epithelial cells. J
Immunol. 195:2122–2133. 2015. View Article : Google Scholar
|
|
15
|
Schneider MA, Granzow M, Warth A, Schnabel
PA, Thomas M, Herth FJ, Dienemann H, Muley T and Meister M:
Glycodelin: A new biomarker with immunomodulatory functions in
non-small cell lung cancer. Clin Cancer Res. 21:3529–3540. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Bustin SA, Benes V, Garson JA, Hellemans
J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley GL,
et al: The MIQE guidelines: Minimum information for publication of
quantitative real-time PCR experiments. Clin Chem. 55:611–622.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
McShane LM, Altman DG, Sauerbrei W, Taube
SE, Gion M and Clark GM; Statistics Subcommittee of NCI-EORTC
Working Group on Cancer Diagnostics. REporting recommendations for
tumor MARKer prognostic studies (REMARK). Breast Cancer Res Treat.
100:229–235. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Saheb Sharif-Askari N, Saheb Sharif-Askari
F, Alabed M, Temsah MH, Al Heialy S, Hamid Q and Halwani R: Airways
expression of SARS-CoV-2 receptor, ACE2, and TMPRSS2 is lower in
children than adults and increases with smoking and COPD. Mol Ther
Methods Clin Dev. 18:1–6. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Qiao Y, Wang XM, Mannan R, Pitchiaya S,
Zhang Y, Wotring JW, Xiao L, Robinson DR, Wu YM, Tien JC, et al:
Targeting transcriptional regulation of SARS-CoV-2 entry factors
ACE2 and TMPRSS2. Proc Natl Acad Sci USA. Dec 11–2020.Epub ahead of
print.
|
|
20
|
Siegel RL, Miller KD and Jemal A: Cancer
statistics, 2020. CA Cancer J Clin. 70:7–30. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Cai L, Luo D, Yao B, Yang DM, Lin S,
Girard L, DeBerardinis RJ, Minna JD, Xie Y and Xiao G: Systematic
analysis of gene expression in lung adenocarcinoma and squamous
cell carcinoma with a case study of FAM83A and FAM83B. Cancers
(Basel). 11:8862019. View Article : Google Scholar
|
|
22
|
Kong Q, Xiang Z, Wu Y, Gu Y, Guo J and
Geng F: Analysis of the susceptibility of lung cancer patients to
SARS-CoV-2 infection. Mol Cancer. 19:802020. View Article : Google Scholar
|
|
23
|
Asselta R, Paraboschi EM, Mantovani A and
Duga S: ACE2 and TMPRSS2 variants and expression as candidates to
sex and country differences in COVID-19 severity in Italy. Aging
(Albany NY). 12:10087–10098. 2020. View Article : Google Scholar
|
|
24
|
Piva F, Sabanovic B, Cecati M and
Giulietti M: Expression and co-expression analyses of TMPRSS2, a
key element in COVID-19. Eur J Clin Microbiol Infect Dis.
40:451–455. 2021. View Article : Google Scholar
|
|
25
|
Yin J, Kasper B, Petersen F and Yu X:
Association of cigarette smoking, COPD, and lung cancer with
expression of SARS-CoV-2 entry genes in human airway epithelial
cells. Front Med (Lausanne). 7:6194532020. View Article : Google Scholar
|
|
26
|
Paoloni-Giacobino A, Chen H, Peitsch MC,
Rossier C and Antonarakis SE: Cloning of the TMPRSS2 gene, which
encodes a novel serine protease with transmembrane, LDLRA, and SRCR
domains and maps to 21q22.3. Genomics. 44:309–320. 1997. View Article : Google Scholar
|
|
27
|
Afar DE, Vivanco I, Hubert RS, Kuo J, Chen
E, Saffran DC, Raitano AB and Jakobovits A: Catalytic cleavage of
the androgen-regulated TMPRSS2 protease results in its secretion by
prostate and prostate cancer epithelia. Cancer Res. 61:1686–1692.
2001.
|
|
28
|
Reid JC, Matsika A, Davies CM, He Y,
Broomfield A, Bennett NC, Magdolen V, Srinivasan B, Clements JA and
Hooper JD: Pericellular regulation of prostate cancer expressed
kallikrein-related peptidases and matrix metalloproteinases by cell
surface serine proteases. Am J Cancer Res. 7:2257–2274. 2017.
|
|
29
|
Jiang Y, Zhuo X, Fu X, Wu Y and Mao C:
Targeting PAR2 overcomes gefitinib resistance in non-small-cell
lung cancer cells through inhibition of EGFR transactivation. Front
Pharmacol. 12:6252892021. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Thomas P, Khokha R, Shepherd FA, Feld R
and Tsao MS: Differential expression of matrix metalloproteinases
and their inhibitors in non-small cell lung cancer. J Pathol.
190:150–156. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Tsai CC, Chou YT and Fu HW:
Protease-activated receptor 2 induces migration and promotes
slug-mediated epithelial-mesenchymal transition in lung
adenocarcinoma cells. Biochim Biophys Acta Mol Cell Res.
1866:486–503. 2019. View Article : Google Scholar
|
|
32
|
Farshchian M, Kivisaari A, Ala-Aho R,
Riihilä P, Kallajoki M, Grénman R, Peltonen J, Pihlajaniemi T,
Heljasvaara R and Kähäri VM: Serpin peptidase inhibitor clade A
member 1 (SerpinA1) is a novel biomarker for progression of
cutaneous squamous cell carcinoma. Am J Pathol. 179:1110–1119.
2011. View Article : Google Scholar
|
|
33
|
de Sa SV, Correa-Giannella ML, Machado MC,
Krogh K, de Almeida MQ, Albergaria Pereira MA, Coelho Siqueira SA,
Patzina RA, Ibuki FS, Sogayar MC, et al: Serpin peptidase inhibitor
clade A member 1 as a potential marker for malignancy in
insulinomas. Clin Cancer Res. 13:5322–5330. 2007. View Article : Google Scholar
|
|
34
|
Chan HJ, Li H, Liu Z, Yuan YC, Mortimer J
and Chen S: SERPINA1 is a direct estrogen receptor target gene and
a predictor of survival in breast cancer patients. Oncotarget.
6:25815–25827. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Zhao W, Yang Z, Liu X, Tian Q, Lv Y, Liang
Y, Li C, Gao X and Chen L: Identification of alpha1-antitrypsin as
a potential prognostic biomarker for advanced nonsmall cell lung
cancer treated with epidermal growth factor receptor tyrosine
kinase inhibitors by proteomic analysis. J Int Med Res. 41:573–583.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Janciauskiene SM, Bals R, Koczulla R,
Vogelmeier C, Kohnlein T and Welte T: The discovery of
alpha1-antitrypsin and its role in health and disease. Respir Med.
105:1129–1139. 2011. View Article : Google Scholar
|
