Role of telomere length in human carcinogenesis (Review)
Affiliations: Laboratory of Toxicology, School of Medicine, University of Crete, 71003 Heraklion, Greece, Creta InterClinic HHG, 71304 Heraklion, Greece, Laboratory of Microbiology, University Hospital of Heraklion, 71500 Heraklion, Greece, Department of Medical Oncology, Venizeleion General Hospital of Heraklion, 71409 Heraklion, Greece, Department of Spine Surgery and Scoliosis, KAT General Hospital, 14561 Athens, Greece, Department of Neonatology and Neonatal Intensive Care Unit (NICU), University Hospital of Heraklion, 71500 Heraklion, Greece, Department of Radiation Oncology, University Hospital of Crete, 71110 Heraklion, Greece, Department of Pharmacology, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119146 Moscow, Russia, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece, Laboratory of Histology‑Embryology, School of Medicine, University of Crete, 71003 Heraklion, Greece, Department of Anatomy, School of Medicine, University of Crete, 71003 Heraklion, Greece
- Published online on: May 22, 2023 https://doi.org/10.3892/ijo.2023.5526
- Article Number: 78
Copyright: © Tsatsakis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...
This article is mentioned in:
Cancer is considered the most important clinical, social and economic issue regarding cause‑specific disability‑adjusted life years among all human pathologies. Exogenous, endogenous and individual factors, including genetic predisposition, participate in cancer triggering. Telomeres are specific DNA structures positioned at the end of chromosomes and consist of repetitive nucleotide sequences, which, together with shelterin proteins, facilitate the maintenance of chromosome stability, while protecting them from genomic erosion. Even though the connection between telomere status and carcinogenesis has been identified, the absence of a universal or even a cancer‑specific trend renders consent even more complex. It is indicative that both short and long telomere lengths have been associated with a high risk of cancer incidence. When evaluating risk associations between cancer and telomere length, a disparity appears to emerge. Even though shorter telomeres have been adopted as a marker of poorer health status and an older biological age, longer telomeres due to increased cell growth potential are associated with the acquirement of cancer‑initiating somatic mutations. Therefore, the present review aimed to comprehensively present the multifaceted pattern of telomere length and cancer incidence association.