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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2005 Volume 27 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2005 Volume 27 Issue 4

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Article

The cachectic mediator proteolysis inducing factor activates NF-κB and STAT3 in human Kupffer cells and monocytes

  • Authors:
    • Tammy M. Watchorn
    • Nabil Dowidar
    • Cornelis H.C. Dejong
    • Ian D. Waddell
    • O. James Garden
    • James A. Ross

  • View Affiliations / Copyright

    Affiliations: Tissue Injury and Repair Group, Cell Injury and Apoptosis Section, Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
  • Pages: 1105-1111
    |
    Published online on: October 1, 2005
       https://doi.org/10.3892/ijo.27.4.1105
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Abstract

A novel proteoglycan, proteolysis inducing factor (PIF), is capable of inducing muscle proteolysis during the process of cancer cachexia, and of inducing an acute phase response in human hepatocytes. We investigated whether PIF is able to activate pro-inflammatory pathways in human Kupffer cells, the resident macrophages of the liver, and in monocytes, resulting in the production of pro-inflammatory cytokines. Normal liver tissue was obtained from patients undergoing partial hepatectomy and Kupffer cells were isolated. Monocytes were isolated from peripheral blood. Following exposure to native PIF, pro-inflammatory cytokine production from Kupffer cells and monocytes was measured and the NF-κB and STAT3 transcriptional pathways were investigated using electrophoretic mobility shift assays. We demonstrate that PIF is able to activate the transcription factor NF-κB and NF-κB-inducible genes in human Kupffer cells, and in monocytes, resulting in the production of pro-inflammatory cytokines such as TNF-α, IL-8 and IL-6. PIF enhances the expression of the cell surface molecules LFA-1 and CD14 on macrophages. PIF also activates the transcription factor STAT3 in Kupffer cells. The pro-inflammatory effects of PIF, mediated via NF-κB and STAT3, are important in macrophage behaviour and may contribute to the inflammatory pro-cachectic process in the liver.

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Copy and paste a formatted citation
Spandidos Publications style
Watchorn TM, Dowidar N, Dejong CH, Waddell ID, Garden OJ and Ross JA: The cachectic mediator proteolysis inducing factor activates NF-κB and STAT3 in human Kupffer cells and monocytes. Int J Oncol 27: 1105-1111, 2005.
APA
Watchorn, T.M., Dowidar, N., Dejong, C.H., Waddell, I.D., Garden, O.J., & Ross, J.A. (2005). The cachectic mediator proteolysis inducing factor activates NF-κB and STAT3 in human Kupffer cells and monocytes. International Journal of Oncology, 27, 1105-1111. https://doi.org/10.3892/ijo.27.4.1105
MLA
Watchorn, T. M., Dowidar, N., Dejong, C. H., Waddell, I. D., Garden, O. J., Ross, J. A."The cachectic mediator proteolysis inducing factor activates NF-κB and STAT3 in human Kupffer cells and monocytes". International Journal of Oncology 27.4 (2005): 1105-1111.
Chicago
Watchorn, T. M., Dowidar, N., Dejong, C. H., Waddell, I. D., Garden, O. J., Ross, J. A."The cachectic mediator proteolysis inducing factor activates NF-κB and STAT3 in human Kupffer cells and monocytes". International Journal of Oncology 27, no. 4 (2005): 1105-1111. https://doi.org/10.3892/ijo.27.4.1105
Copy and paste a formatted citation
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Spandidos Publications style
Watchorn TM, Dowidar N, Dejong CH, Waddell ID, Garden OJ and Ross JA: The cachectic mediator proteolysis inducing factor activates NF-κB and STAT3 in human Kupffer cells and monocytes. Int J Oncol 27: 1105-1111, 2005.
APA
Watchorn, T.M., Dowidar, N., Dejong, C.H., Waddell, I.D., Garden, O.J., & Ross, J.A. (2005). The cachectic mediator proteolysis inducing factor activates NF-κB and STAT3 in human Kupffer cells and monocytes. International Journal of Oncology, 27, 1105-1111. https://doi.org/10.3892/ijo.27.4.1105
MLA
Watchorn, T. M., Dowidar, N., Dejong, C. H., Waddell, I. D., Garden, O. J., Ross, J. A."The cachectic mediator proteolysis inducing factor activates NF-κB and STAT3 in human Kupffer cells and monocytes". International Journal of Oncology 27.4 (2005): 1105-1111.
Chicago
Watchorn, T. M., Dowidar, N., Dejong, C. H., Waddell, I. D., Garden, O. J., Ross, J. A."The cachectic mediator proteolysis inducing factor activates NF-κB and STAT3 in human Kupffer cells and monocytes". International Journal of Oncology 27, no. 4 (2005): 1105-1111. https://doi.org/10.3892/ijo.27.4.1105
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