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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2006 Volume 28 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2006 Volume 28 Issue 2

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Article

Clinical significance of class III β-tubulin expression and its predictive value for resistance to docetaxel-based chemotherapy in gastric cancer

  • Authors:
    • Naomi Urano
    • Yoshiyuki Fujiwara
    • Yuichiro Doki
    • S. J. Kim
    • Yasuo Miyoshi
    • Shinzaburo Noguchi
    • Hiroshi Miyata
    • Shuji Takiguchi
    • Takushi Yasuda
    • Masahiko Yano
    • Morito Monden

  • View Affiliations / Copyright

    Affiliations: Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan
  • Pages: 375-381
    |
    Published online on: February 1, 2006
       https://doi.org/10.3892/ijo.28.2.375
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Abstract

Docetaxel, one of the most effective anticancer drugs for gastric cancer, targets β-tubulin, the major protein in mitotic spindles. Eight isotypes of β-tubulin, with tissue and organ-specific expression, have been identified in mammalian cells. We examined class III β-tubulin expression in gastric cancer and assessed its relationship with sensitivity to docetaxel-based chemotherapy. A total of 115 paraffin-embedded gastric tumors were analyzed by immunohistochemistry for class III β-tubulin expression. Twenty patients with advanced gastric cancer received preoperative docetaxel-based chemotherapy. Their biopsied specimens, obtained by endoscopy before chemotherapy were examined for class III β-tubulin expression. The relationship between expression and chemosensitivity was assessed. Forty-two (36.4%) of 115 cases were confirmed to be positive for class III β-tubulin expression. There was no association between clinicopathological status and prognosis. Among the patients positive for class III β-tubulin expression, only 16.7% showed no response to chemotherapy, while 64.3% responded to the chemotherapy in the negative group. Our results suggest that class III β-tubulin is a simple and useful predictive marker for the clinical response to docetaxel-based chemotherapy in gastric cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Urano N, Fujiwara Y, Doki Y, Kim SJ, Miyoshi Y, Noguchi S, Miyata H, Takiguchi S, Yasuda T, Yano M, Yano M, et al: Clinical significance of class III β-tubulin expression and its predictive value for resistance to docetaxel-based chemotherapy in gastric cancer. Int J Oncol 28: 375-381, 2006.
APA
Urano, N., Fujiwara, Y., Doki, Y., Kim, S.J., Miyoshi, Y., Noguchi, S. ... Monden, M. (2006). Clinical significance of class III β-tubulin expression and its predictive value for resistance to docetaxel-based chemotherapy in gastric cancer. International Journal of Oncology, 28, 375-381. https://doi.org/10.3892/ijo.28.2.375
MLA
Urano, N., Fujiwara, Y., Doki, Y., Kim, S. J., Miyoshi, Y., Noguchi, S., Miyata, H., Takiguchi, S., Yasuda, T., Yano, M., Monden, M."Clinical significance of class III β-tubulin expression and its predictive value for resistance to docetaxel-based chemotherapy in gastric cancer". International Journal of Oncology 28.2 (2006): 375-381.
Chicago
Urano, N., Fujiwara, Y., Doki, Y., Kim, S. J., Miyoshi, Y., Noguchi, S., Miyata, H., Takiguchi, S., Yasuda, T., Yano, M., Monden, M."Clinical significance of class III β-tubulin expression and its predictive value for resistance to docetaxel-based chemotherapy in gastric cancer". International Journal of Oncology 28, no. 2 (2006): 375-381. https://doi.org/10.3892/ijo.28.2.375
Copy and paste a formatted citation
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Spandidos Publications style
Urano N, Fujiwara Y, Doki Y, Kim SJ, Miyoshi Y, Noguchi S, Miyata H, Takiguchi S, Yasuda T, Yano M, Yano M, et al: Clinical significance of class III β-tubulin expression and its predictive value for resistance to docetaxel-based chemotherapy in gastric cancer. Int J Oncol 28: 375-381, 2006.
APA
Urano, N., Fujiwara, Y., Doki, Y., Kim, S.J., Miyoshi, Y., Noguchi, S. ... Monden, M. (2006). Clinical significance of class III β-tubulin expression and its predictive value for resistance to docetaxel-based chemotherapy in gastric cancer. International Journal of Oncology, 28, 375-381. https://doi.org/10.3892/ijo.28.2.375
MLA
Urano, N., Fujiwara, Y., Doki, Y., Kim, S. J., Miyoshi, Y., Noguchi, S., Miyata, H., Takiguchi, S., Yasuda, T., Yano, M., Monden, M."Clinical significance of class III β-tubulin expression and its predictive value for resistance to docetaxel-based chemotherapy in gastric cancer". International Journal of Oncology 28.2 (2006): 375-381.
Chicago
Urano, N., Fujiwara, Y., Doki, Y., Kim, S. J., Miyoshi, Y., Noguchi, S., Miyata, H., Takiguchi, S., Yasuda, T., Yano, M., Monden, M."Clinical significance of class III β-tubulin expression and its predictive value for resistance to docetaxel-based chemotherapy in gastric cancer". International Journal of Oncology 28, no. 2 (2006): 375-381. https://doi.org/10.3892/ijo.28.2.375
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