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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Clinical experience with radio-, chemo- and hyperthermotherapy combined trimodality on locally advanced esophageal cancer

  • Authors:
    • Haiwen Zhu
    • Xudong Huo
    • Longyun Chen
    • Hanhua Wang
    • Hongliang Yu

  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Yancheng Third People's Hospital, Yancheng, Jiangsu 224000, P.R. China, Department of Radiation Oncology, Jiangsu Cancer Hospital, Nanjing, Jiangsu 210000, P.R. China
  • Pages: 1009-1012
    |
    Published online on: July 26, 2013
       https://doi.org/10.3892/mco.2013.161
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Abstract

Esophageal cancer is a highly malignant and lethal disease with a low 5-year survival rate. Therefore, an effective treatment modality is required. To investigate the treatment efficacy and toxicity of radio-, chemo- and hyperthermotherapy combined trimodality on locally advanced esophageal cancer, the medical records of 78 patients with pathologically confirmed esophageal cancer treated with chemoradiotherapy plus hyperthemia at our institution were retrospectively investigated and the 3‑year outcome was carefully assessed. All 78 patients received intensity‑modulated radiation therapy at a total dose of 60-66 Gy, in a conventional schedule of 1.8-2.1 Gy/fraction, 5 fractions/week. They also received 4-6 courses of chemotherapy, consisting of 450 mg/m2 5‑fluorouracil for 1‑5 days and 25 mg/m2 cisplatin for 1‑5 days, in addition to 6-12 sessions of hyperthermia, performed twice a week. Out of the 78 cases, complete remission of the primary tumor was observed in 31 (39.7%), partial remission in 44 (56.4%) and no change in 3 (3.9%) cases. The treatment response rate was 96.1%. The overall survival (OS) rate at 1, 2 and 3 years was 67.9, 41.0 and 33.3%, respectively. No significant difference in adverse effects was observed between this treatment regimen and other similar studies. Our preliminary results demonstrated that the chemo-, radio- and hyperthermotherapy combined trimodality exhibited excellent short‑term clinical outcomes as regards tumor response rate and a sound long‑term OS, with endurable adverse events. This trimodal treatment requires further investigation to establish its beneficial role in the treatment of patients with locally advanced esophageal cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu H, Huo X, Chen L, Wang H and Yu H: Clinical experience with radio-, chemo- and hyperthermotherapy combined trimodality on locally advanced esophageal cancer. Mol Clin Oncol 1: 1009-1012, 2013.
APA
Zhu, H., Huo, X., Chen, L., Wang, H., & Yu, H. (2013). Clinical experience with radio-, chemo- and hyperthermotherapy combined trimodality on locally advanced esophageal cancer. Molecular and Clinical Oncology, 1, 1009-1012. https://doi.org/10.3892/mco.2013.161
MLA
Zhu, H., Huo, X., Chen, L., Wang, H., Yu, H."Clinical experience with radio-, chemo- and hyperthermotherapy combined trimodality on locally advanced esophageal cancer". Molecular and Clinical Oncology 1.6 (2013): 1009-1012.
Chicago
Zhu, H., Huo, X., Chen, L., Wang, H., Yu, H."Clinical experience with radio-, chemo- and hyperthermotherapy combined trimodality on locally advanced esophageal cancer". Molecular and Clinical Oncology 1, no. 6 (2013): 1009-1012. https://doi.org/10.3892/mco.2013.161
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu H, Huo X, Chen L, Wang H and Yu H: Clinical experience with radio-, chemo- and hyperthermotherapy combined trimodality on locally advanced esophageal cancer. Mol Clin Oncol 1: 1009-1012, 2013.
APA
Zhu, H., Huo, X., Chen, L., Wang, H., & Yu, H. (2013). Clinical experience with radio-, chemo- and hyperthermotherapy combined trimodality on locally advanced esophageal cancer. Molecular and Clinical Oncology, 1, 1009-1012. https://doi.org/10.3892/mco.2013.161
MLA
Zhu, H., Huo, X., Chen, L., Wang, H., Yu, H."Clinical experience with radio-, chemo- and hyperthermotherapy combined trimodality on locally advanced esophageal cancer". Molecular and Clinical Oncology 1.6 (2013): 1009-1012.
Chicago
Zhu, H., Huo, X., Chen, L., Wang, H., Yu, H."Clinical experience with radio-, chemo- and hyperthermotherapy combined trimodality on locally advanced esophageal cancer". Molecular and Clinical Oncology 1, no. 6 (2013): 1009-1012. https://doi.org/10.3892/mco.2013.161
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