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Molecular and Clinical Oncology
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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Usefulness of palliative prognostic score in the treatment of patients with non-resectable gastric cancer

  • Authors:
    • Masahide Ikeguchi
    • Abdul Kader
    • Miwa Yoshimoto
    • Seigo Takaya
    • Joji Watanabe
    • Youji Fukumoto
    • Tomohiro Osaki
    • Hiroaki Saito
    • Shigeru Tatebe
    • Toshiro Wakatsuki
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Division of Surgical Oncology, Faculty of Medicine, Tottori University, Yonago 683-8504, Japan
  • Pages: 253-256
    |
    Published online on: January 14, 2013
       https://doi.org/10.3892/mco.2013.66
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Abstract

The aim of this study was to evaluate the clinical usefulness of the palliative prognostic (PaP) score in patients with non-resectable advanced gastric cancer. The PaP score was calculated prior to each course of chemotherapy in 44 consecutive patients with non-resectable advanced gastric cancer between 2003 and 2010 at the Tottori University Hospital, Yonago, Japan. The prognosis was evaluated according to the PaP score and the different chemotherapeutic agents. The median survival time (MST) was 10 months. The PaP score classified the heterogeneous patient sample into three isoprognostic groups with regard to the possibility of a 1‑month survival period, with 28 patients in group A (>70% chance), 12 in group B (30-70% chance) and 4 in group C (<30% chance). The MST of the three groups was 11, 3 and 1 months for group A, B and C, respectively. In group A, chemotherapeutic regimens did not affect patient survival, although the docetaxel regimen prolonged survival of patients in group B. In conclusion, the PaP score may be useful in selecting the best chemotherapeutic regimen in patients with non-resectable gastric cancer.
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1 

Murad AM, Santiago FF, Petroianu A, Rocha PR, Rodrigues MA and Rausch M: Modified therapy with 5-fluorouracil, doxorubicin, and methotrexate in advanced gastric cancer. Cancer. 72:37–41. 1993. View Article : Google Scholar : PubMed/NCBI

2 

Glimelius B, Hoffman K, Haglund U, Nyren O and Sjoden PO: Initial or delayed chemotherapy with best supportive care in advanced gastric cancer. Ann Oncol. 5:189–190. 1994.PubMed/NCBI

3 

Shirasaka T, Shimamato Y, Ohshima H, Yamaguchi M, Kato T, Yonekura K and Fukushima M: Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators. Anticancer Drugs. 7:548–557. 1996. View Article : Google Scholar : PubMed/NCBI

4 

Sakata Y, Ohtsu A, Horikoshi N, Sugimachi K, Mitachi Y and Taguchi T: Late phase II study of novel oral fluoropyrimidine anticancer drug S-1 (1 M tegafur-0.4 M gimestat-1 M otastat potassium) in advanced gastric cancer patients. Eur J Cancer. 34:1715–1720. 1998. View Article : Google Scholar : PubMed/NCBI

5 

Koizumi W, Kurihara M, Nakano S and Hasegawa K: Phase II study of S-1, a novel oral derivative of 5-fluorouracil, in advanced gastric cancer. For the S-1 Cooperative Gastric Cancer Study Group. Oncology. 58:191–197. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Koizumi W, Narahara H, Hara T, Takagane A, Akiya T, Takagi M, Miyashita K, Nishizaki T, Kobayashi O, Takiyama W, Toh Y, Nagaie T, Takagi S, Yamamura Y, Yanaoka K, Orita H and Takeuchi M: S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial. Lancet Oncol. 9:215–221. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Koo DH, Ryu MH, Ryoo BY, Lee SS, Moon JH, Chang HM, Lee JL, Kim TW and Kang YK: Three-week combination chemotherapy with S-1 and cisplatin as first-line treatment in patients with advanced gastric cancer: a retrospective study with 159 patients. Gastric Cancer. 15:305–312. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Casaretto L, Sousa PLR and Mari JJ: Chemotherapy versus support cancer treatment in advanced gastric cancer: a meta-analysis. Braz J Med Biol Res. 39:431–440. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Pirovano M, Maltoni M, Nanni O, Marinari M, Indelli M, Zaninetta G, Petrella V, Bami S, Zecca E, Scarpi E, Labianca R, Amadori D and Luporini G: A new palliative prognostic score: A first step for the staging of terminally ill cancer patients. J Pain Symptom Manage. 17:231–239. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Tassinari D, Montanari L, Maltoni M, Ballardini M, Piancastelli A, Musi M, Porzio G, Minotti V, Caraceni A, Poggi B, Stella A, Aielli F and Scarpi E: The palliative prognostic score and survival in patients with advanced solid tumors receiving chemotherapy. Support Care Cancer. 16:359–370. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Maltoni M, Nanni O, Pirovano M, Scarpi E, Indelli M, Martini C, Monti M, Amoldi E, Piva L, Ravaioli A, Cruciani G, Labianca R and Amadori D: Successful validation of the palliative prognostic score in terminally ill cancer patients. J Pain Symptom Manage. 17:240–247. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Japanese Gastric Cancer Association: Japanese classification of gastric carcinoma. 3rd English edition. Gastric Cancer. 14:101–112. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Geels P, Eisenhauer E, Bezjak A, Zee B and Day A: Palliative effect of chemotherapy: objective tumor response is associated with symptom improvement in patients with metastatic breast cancer. J Clin Oncol. 18:2395–2405. 2000.PubMed/NCBI

14 

Browner I and Carducci MA: Palliative chemotherapy: historical perspective, applications and controversies. Semin Oncol. 32:145–155. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Glare PA, Eychmueller S and McMahon P: Diagnostic accuracy of the palliative prognostic score in hospitalized patients with advanced cancer. J Clin Oncol. 22:4823–4828. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Stone CA, Tiernan E and Dooley BA: Prospective validation of the palliative prognostic index in patients with cancer. J Pain Symptom Manage. 35:617–622. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Stiel S, Bertram L, Neuhaus S, Nauck F, Ostgathe C, Elsner F and Radbruch L: Evaluation and comparison of two prognostic scores and the physicians’ estimate of survival in terminally ill patients. Support Care Cancer. 18:43–49. 2010.

18 

Massacesi C, Marcucci F, Rocchi MB, Mazzanti P, Pilone A and Bonsignori M: Factors predicting docetaxel-related toxicity: experience at a single institution. J Chemother. 16:86–93. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Fujii M: Chemotherapy for advanced gastric cancer: ongoing phase III study of S-1 alone versus S-1 and docetaxel combination (JACCRO GC03 study). Int J Clin Oncol. 13:201–205. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ikeguchi M, Kader A, Yoshimoto M, Takaya S, Watanabe J, Fukumoto Y, Osaki T, Saito H, Tatebe S, Wakatsuki T, Wakatsuki T, et al: Usefulness of palliative prognostic score in the treatment of patients with non-resectable gastric cancer. Mol Clin Oncol 1: 253-256, 2013.
APA
Ikeguchi, M., Kader, A., Yoshimoto, M., Takaya, S., Watanabe, J., Fukumoto, Y. ... Wakatsuki, T. (2013). Usefulness of palliative prognostic score in the treatment of patients with non-resectable gastric cancer. Molecular and Clinical Oncology, 1, 253-256. https://doi.org/10.3892/mco.2013.66
MLA
Ikeguchi, M., Kader, A., Yoshimoto, M., Takaya, S., Watanabe, J., Fukumoto, Y., Osaki, T., Saito, H., Tatebe, S., Wakatsuki, T."Usefulness of palliative prognostic score in the treatment of patients with non-resectable gastric cancer". Molecular and Clinical Oncology 1.2 (2013): 253-256.
Chicago
Ikeguchi, M., Kader, A., Yoshimoto, M., Takaya, S., Watanabe, J., Fukumoto, Y., Osaki, T., Saito, H., Tatebe, S., Wakatsuki, T."Usefulness of palliative prognostic score in the treatment of patients with non-resectable gastric cancer". Molecular and Clinical Oncology 1, no. 2 (2013): 253-256. https://doi.org/10.3892/mco.2013.66
Copy and paste a formatted citation
x
Spandidos Publications style
Ikeguchi M, Kader A, Yoshimoto M, Takaya S, Watanabe J, Fukumoto Y, Osaki T, Saito H, Tatebe S, Wakatsuki T, Wakatsuki T, et al: Usefulness of palliative prognostic score in the treatment of patients with non-resectable gastric cancer. Mol Clin Oncol 1: 253-256, 2013.
APA
Ikeguchi, M., Kader, A., Yoshimoto, M., Takaya, S., Watanabe, J., Fukumoto, Y. ... Wakatsuki, T. (2013). Usefulness of palliative prognostic score in the treatment of patients with non-resectable gastric cancer. Molecular and Clinical Oncology, 1, 253-256. https://doi.org/10.3892/mco.2013.66
MLA
Ikeguchi, M., Kader, A., Yoshimoto, M., Takaya, S., Watanabe, J., Fukumoto, Y., Osaki, T., Saito, H., Tatebe, S., Wakatsuki, T."Usefulness of palliative prognostic score in the treatment of patients with non-resectable gastric cancer". Molecular and Clinical Oncology 1.2 (2013): 253-256.
Chicago
Ikeguchi, M., Kader, A., Yoshimoto, M., Takaya, S., Watanabe, J., Fukumoto, Y., Osaki, T., Saito, H., Tatebe, S., Wakatsuki, T."Usefulness of palliative prognostic score in the treatment of patients with non-resectable gastric cancer". Molecular and Clinical Oncology 1, no. 2 (2013): 253-256. https://doi.org/10.3892/mco.2013.66
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