Radiotherapy and chemoradiotherapy as a novel option for the treatment of locally advanced inoperable gastric adenocarcinoma: A phase II study

Wydmanski,Jerzy; Grabinska,Kinga; Polanowski,Pawel; Namysl‑Kaletka,Agnieszka; Kawczynski,Rafal; Kraszkiewicz,Malgorzata; Majewski,Wojciech

doi:10.3892/mco.2014.348

November-December 2014 Volume 2 Issue 6

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November-December 2014 Volume 2 Issue 6

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Article

Radiotherapy and chemoradiotherapy as a novel option for the treatment of locally advanced inoperable gastric adenocarcinoma: A phase II study

Authors:
- Jerzy Wydmanski
- Kinga Grabinska
- Pawel Polanowski
- Agnieszka Namysl‑Kaletka
- Rafal Kawczynski
- Malgorzata Kraszkiewicz
- Wojciech Majewski
View Affiliations / Copyright

Affiliations: Department of Radiotherapy, Maria Sklodowska‑Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, 44‑101 Gliwice, Poland
Pages: 1150-1154
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Published online on: July 11, 2014

https://doi.org/10.3892/mco.2014.348
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Abstract

This phase II trial aimed to evaluate the tolerance and efficacy of radical radiotherapy or chemoradiotherapy in patients with primarily inoperable gastric cancer. The analysis was based on 13 patients with primarily inoperable gastric cancer. A total of 6 (46.2%) patients refused surgery and 7 (53.8%) had contraindications to anesthesia due to cardiological or respiratory reasons (4 and 3 patients, respectively). The treatment regimen consisted of radiotherapy and chemotherapy based on 5‑fluorouracil. Half of the patients were not qualified to receive chemotherapy due to the presence of comorbidities. A total dose of 45 Gy was administered in 25 fractions. Of the 13 patients who started treatment, 12 (92.3%) completed radiotherapy. Local treatment response was observed in 6/12 patients (50%), with 5/12 (41.7%) displaying clinical complete response and 1/12 (8.3%) partial response. The 1‑ and 3‑year overall survival rates and the median survival were 59 and 48% and 17.1 months, respectively. In conclusion, radical radiotherapy, either alone or in combination with chemotherapy, is safe for patients with inoperable locally advanced gastric cancer and may prolong survival.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Radiotherapy and chemoradiotherapy as a novel option for the treatment of locally advanced inoperable gastric adenocarcinoma: A phase II study

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