Radiotherapy and chemoradiotherapy as a novel option for the treatment of locally advanced inoperable gastric adenocarcinoma: A phase II study

  • Authors:
    • Jerzy Wydmanski
    • Kinga Grabinska
    • Pawel Polanowski
    • Agnieszka Namysl‑Kaletka
    • Rafal Kawczynski
    • Malgorzata Kraszkiewicz
    • Wojciech Majewski
  • View Affiliations

  • Published online on: July 11, 2014     https://doi.org/10.3892/mco.2014.348
  • Pages: 1150-1154
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Abstract

This phase II trial aimed to evaluate the tolerance and efficacy of radical radiotherapy or chemoradiotherapy in patients with primarily inoperable gastric cancer. The analysis was based on 13 patients with primarily inoperable gastric cancer. A total of 6 (46.2%) patients refused surgery and 7 (53.8%) had contraindications to anesthesia due to cardiological or respiratory reasons (4 and 3 patients, respectively). The treatment regimen consisted of radiotherapy and chemotherapy based on 5‑fluorouracil. Half of the patients were not qualified to receive chemotherapy due to the presence of comorbidities. A total dose of 45 Gy was administered in 25 fractions. Of the 13 patients who started treatment, 12 (92.3%) completed radiotherapy. Local treatment response was observed in 6/12 patients (50%), with 5/12 (41.7%) displaying clinical complete response and 1/12 (8.3%) partial response. The 1‑ and 3‑year overall survival rates and the median survival were 59 and 48% and 17.1 months, respectively. In conclusion, radical radiotherapy, either alone or in combination with chemotherapy, is safe for patients with inoperable locally advanced gastric cancer and may prolong survival.
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November-December 2014
Volume 2 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Wydmanski J, Grabinska K, Polanowski P, Namysl‑Kaletka A, Kawczynski R, Kraszkiewicz M and Majewski W: Radiotherapy and chemoradiotherapy as a novel option for the treatment of locally advanced inoperable gastric adenocarcinoma: A phase II study. Mol Clin Oncol 2: 1150-1154, 2014
APA
Wydmanski, J., Grabinska, K., Polanowski, P., Namysl‑Kaletka, A., Kawczynski, R., Kraszkiewicz, M., & Majewski, W. (2014). Radiotherapy and chemoradiotherapy as a novel option for the treatment of locally advanced inoperable gastric adenocarcinoma: A phase II study. Molecular and Clinical Oncology, 2, 1150-1154. https://doi.org/10.3892/mco.2014.348
MLA
Wydmanski, J., Grabinska, K., Polanowski, P., Namysl‑Kaletka, A., Kawczynski, R., Kraszkiewicz, M., Majewski, W."Radiotherapy and chemoradiotherapy as a novel option for the treatment of locally advanced inoperable gastric adenocarcinoma: A phase II study". Molecular and Clinical Oncology 2.6 (2014): 1150-1154.
Chicago
Wydmanski, J., Grabinska, K., Polanowski, P., Namysl‑Kaletka, A., Kawczynski, R., Kraszkiewicz, M., Majewski, W."Radiotherapy and chemoradiotherapy as a novel option for the treatment of locally advanced inoperable gastric adenocarcinoma: A phase II study". Molecular and Clinical Oncology 2, no. 6 (2014): 1150-1154. https://doi.org/10.3892/mco.2014.348