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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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October-2020 Volume 13 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Prognostic role of baseline neutrophil‑to‑lymphocyte ratio in metastatic solid tumors

  • Authors:
    • Amanda Zucker
    • Alex Winter
    • Dean Lumley
    • Pawel Karwowski
    • Min-Kyung Jung
    • Johnny Kao
  • View Affiliations / Copyright

    Affiliations: College of Osteopathic Medicine, New York Institute of Technology, Glen Head, NY 11545, USA, Department of Radiation Oncology, Good Samaritan Hospital Medical Center, West Islip, NY 11795, USA
  • Article Number: 25
    |
    Published online on: July 16, 2020
       https://doi.org/10.3892/mco.2020.2095
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Abstract

High baseline neutrophil‑to‑lymphocyte ratio (NLR) has been associated with poor survival in a number of solid tumors, but has not been extensively investigated in the context of radiation oncology. Developing more robust models to predict survival would inform patient care for patients with metastatic solid tumors. The present study was undertaken to evaluate the effect of baseline NLR (using 4 as a cutoff) on survival in 320 consecutive patients with metastatic cancer who were referred to a single radiation oncologist between 2012 and 2015, with a median follow‑up of 20.6 months. The median NLR was 4.4 (interquartile range, 2.8‑7.2). Patients with a baseline NLR ≤4 had a median survival of 9.3 months compared to 4.1 months for NLR >4 (P<0.001). The number of active tumors, Eastern Cooperative Oncology Group performance status score, baseline albumin, primary tumor site, liver metastases and baseline NLR predicted overall survival on both univariate and multivariate analysis (P<0.05 for all). After adjusting for known prognostic factors for advanced solid tumors, baseline NLR >4 independently predicted adverse survival in this cohort.
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Copy and paste a formatted citation
Spandidos Publications style
Zucker A, Winter A, Lumley D, Karwowski P, Jung M and Kao J: Prognostic role of baseline neutrophil‑to‑lymphocyte ratio in metastatic solid tumors. Mol Clin Oncol 13: 25, 2020.
APA
Zucker, A., Winter, A., Lumley, D., Karwowski, P., Jung, M., & Kao, J. (2020). Prognostic role of baseline neutrophil‑to‑lymphocyte ratio in metastatic solid tumors. Molecular and Clinical Oncology, 13, 25. https://doi.org/10.3892/mco.2020.2095
MLA
Zucker, A., Winter, A., Lumley, D., Karwowski, P., Jung, M., Kao, J."Prognostic role of baseline neutrophil‑to‑lymphocyte ratio in metastatic solid tumors". Molecular and Clinical Oncology 13.4 (2020): 25.
Chicago
Zucker, A., Winter, A., Lumley, D., Karwowski, P., Jung, M., Kao, J."Prognostic role of baseline neutrophil‑to‑lymphocyte ratio in metastatic solid tumors". Molecular and Clinical Oncology 13, no. 4 (2020): 25. https://doi.org/10.3892/mco.2020.2095
Copy and paste a formatted citation
x
Spandidos Publications style
Zucker A, Winter A, Lumley D, Karwowski P, Jung M and Kao J: Prognostic role of baseline neutrophil‑to‑lymphocyte ratio in metastatic solid tumors. Mol Clin Oncol 13: 25, 2020.
APA
Zucker, A., Winter, A., Lumley, D., Karwowski, P., Jung, M., & Kao, J. (2020). Prognostic role of baseline neutrophil‑to‑lymphocyte ratio in metastatic solid tumors. Molecular and Clinical Oncology, 13, 25. https://doi.org/10.3892/mco.2020.2095
MLA
Zucker, A., Winter, A., Lumley, D., Karwowski, P., Jung, M., Kao, J."Prognostic role of baseline neutrophil‑to‑lymphocyte ratio in metastatic solid tumors". Molecular and Clinical Oncology 13.4 (2020): 25.
Chicago
Zucker, A., Winter, A., Lumley, D., Karwowski, P., Jung, M., Kao, J."Prognostic role of baseline neutrophil‑to‑lymphocyte ratio in metastatic solid tumors". Molecular and Clinical Oncology 13, no. 4 (2020): 25. https://doi.org/10.3892/mco.2020.2095
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