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Postoperative C‑reactive protein‑to‑albumin ratio predicts poor prognosis in patients with bladder cancer undergoing radial cystectomy

  • Authors:
    • Kenji Kuroda
    • Shinsuke Tasaki
    • Akio Horiguchi
    • Keiichi Ito
  • View Affiliations / Copyright

    Affiliations: Department of Urology, National Defense Medical College, Tokorozawa, Saitama 359‑8513, Japan
    Copyright: © Kuroda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 54
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    Published online on: January 21, 2021
       https://doi.org/10.3892/mco.2021.2216
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Abstract

The purpose of the present study was to investigate the prognostic value of the postoperative C‑reactive protein/albumin ratio (CAR) in patients with bladder cancer undergoing radial cystectomy. The present study retrospectively reviewed 102 patients who underwent radical cystectomy and were followed for ≥6 months postoperatively at our institution, and evaluated clinicopathological factors and laboratory parameters for cancer‑specific survival (CSS) and extraurothelial recurrence‑free survival (ERFS). Multivariate analysis using the Cox proportional hazards model revealed that only postoperative CAR ≥0.27 [hazard ratio (HR), 3.368; 95% confidence interval (CI), 1.674‑6.731; P<0.001] was an independent factor for poor CSS rate. Higher postoperative CAR was also the only significant factor for shortened ERFS time (HR, 2.401; 95% CI, 1.196‑4.684; P=0.015). No significant association was identified between postoperative CAR ≥0.27 and any pathological factors or postoperative laboratory markers besides postoperative neutrophil‑to‑lymphocyte ratio. Furthermore, postoperative CAR (≥0.27) was an independent factor for poor CSS and ERFS rates in 48 patients with advanced pT stage (≥pT3) in the multivariate analysis (P=0.026 and P=0.036, respectively). A higher postoperative CAR value can provide additional information about the possibility of poor CSS and ERFS rates in patients with bladder cancer undergoing radical cystectomy.
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Copy and paste a formatted citation
Spandidos Publications style
Kuroda K, Tasaki S, Horiguchi A and Ito K: Postoperative C‑reactive protein‑to‑albumin ratio predicts poor prognosis in patients with bladder cancer undergoing radial cystectomy. Mol Clin Oncol 14: 54, 2021.
APA
Kuroda, K., Tasaki, S., Horiguchi, A., & Ito, K. (2021). Postoperative C‑reactive protein‑to‑albumin ratio predicts poor prognosis in patients with bladder cancer undergoing radial cystectomy. Molecular and Clinical Oncology, 14, 54. https://doi.org/10.3892/mco.2021.2216
MLA
Kuroda, K., Tasaki, S., Horiguchi, A., Ito, K."Postoperative C‑reactive protein‑to‑albumin ratio predicts poor prognosis in patients with bladder cancer undergoing radial cystectomy". Molecular and Clinical Oncology 14.3 (2021): 54.
Chicago
Kuroda, K., Tasaki, S., Horiguchi, A., Ito, K."Postoperative C‑reactive protein‑to‑albumin ratio predicts poor prognosis in patients with bladder cancer undergoing radial cystectomy". Molecular and Clinical Oncology 14, no. 3 (2021): 54. https://doi.org/10.3892/mco.2021.2216
Copy and paste a formatted citation
x
Spandidos Publications style
Kuroda K, Tasaki S, Horiguchi A and Ito K: Postoperative C‑reactive protein‑to‑albumin ratio predicts poor prognosis in patients with bladder cancer undergoing radial cystectomy. Mol Clin Oncol 14: 54, 2021.
APA
Kuroda, K., Tasaki, S., Horiguchi, A., & Ito, K. (2021). Postoperative C‑reactive protein‑to‑albumin ratio predicts poor prognosis in patients with bladder cancer undergoing radial cystectomy. Molecular and Clinical Oncology, 14, 54. https://doi.org/10.3892/mco.2021.2216
MLA
Kuroda, K., Tasaki, S., Horiguchi, A., Ito, K."Postoperative C‑reactive protein‑to‑albumin ratio predicts poor prognosis in patients with bladder cancer undergoing radial cystectomy". Molecular and Clinical Oncology 14.3 (2021): 54.
Chicago
Kuroda, K., Tasaki, S., Horiguchi, A., Ito, K."Postoperative C‑reactive protein‑to‑albumin ratio predicts poor prognosis in patients with bladder cancer undergoing radial cystectomy". Molecular and Clinical Oncology 14, no. 3 (2021): 54. https://doi.org/10.3892/mco.2021.2216
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