Open Access

IgD multiple myeloma with central nervous system involvement: A case report and literature review

  • Authors:
    • Yi Chen
    • Yanyan Qiu
    • Haiying Fu
    • Jing Li
    • Lushan Chen
    • Siqin Liao
    • Tingbo Liu
  • View Affiliations

  • Published online on: August 4, 2021     https://doi.org/10.3892/mco.2021.2360
  • Article Number: 198
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Central nervous system (CNS) involvement is a rare manifestation of multiple myeloma (MM) and the optimal management strategies have yet to be determined. The aim of the present study was to describe the case of a 47‑year‑old male patient with immunoglobulin D‑λ MM who presented with multiple extramedullary infiltrations at diagnosis. This patient achieved stringent complete response after 9 cycles of treatment with bortezomib, lenalidomide and dexamethasone, and then received lenalidomide as maintenance therapy. CNS involvement and extramedullary relapse developed 3 months after the last chemotherapy cycle. Despite receiving a second‑line treatment protocol, the patient succumbed to the disease within 1 month after recurrence. The characteristics and treatment options for CNS MM are discussed in this case report.
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October-2021
Volume 15 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Copy and paste a formatted citation
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Spandidos Publications style
Chen Y, Qiu Y, Fu H, Li J, Chen L, Liao S and Liu T: IgD multiple myeloma with central nervous system involvement: A case report and literature review. Mol Clin Oncol 15: 198, 2021
APA
Chen, Y., Qiu, Y., Fu, H., Li, J., Chen, L., Liao, S., & Liu, T. (2021). IgD multiple myeloma with central nervous system involvement: A case report and literature review. Molecular and Clinical Oncology, 15, 198. https://doi.org/10.3892/mco.2021.2360
MLA
Chen, Y., Qiu, Y., Fu, H., Li, J., Chen, L., Liao, S., Liu, T."IgD multiple myeloma with central nervous system involvement: A case report and literature review". Molecular and Clinical Oncology 15.4 (2021): 198.
Chicago
Chen, Y., Qiu, Y., Fu, H., Li, J., Chen, L., Liao, S., Liu, T."IgD multiple myeloma with central nervous system involvement: A case report and literature review". Molecular and Clinical Oncology 15, no. 4 (2021): 198. https://doi.org/10.3892/mco.2021.2360