Complete remission of stage IV sinonasal small cell neuroendocrine carcinoma: A case report

Raposo,Alberto; Martínez‑Ortiz,María José; Buendía,Ana; Guillén,Elena; Bermúdez,Cristina; García‑Purriños,Francisco

doi:10.3892/mco.2021.2481

February-2022 Volume 16 Issue 2

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February-2022 Volume 16 Issue 2

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Case Report

Complete remission of stage IV sinonasal small cell neuroendocrine carcinoma: A case report

Authors:
- Alberto Raposo
- María José Martínez‑Ortiz
- Ana Buendía
- Elena Guillén
- Cristina Bermúdez
- Francisco García‑Purriños
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Affiliations: Department of Otorhinolaryngology‑Head and Neck Surgery, Hospital Universitario Los Arcos del Mar Menor, San Javier, 30739 Murcia, Spain, Department of Medical Oncology, Hospital Universitario Santa Lucia, Cartagena, 30202 Murcia, Spain, Department of Anatomical Pathology, Hospital Universitario Los Arcos del Mar Menor, San Javier, 30739 Murcia, Spain, Department of Anatomic Pathology, Hospital Universitario Santa Lucia, Cartagena, 30202 Murcia, Spain, Department of Radiology, Hospital Universitario Los Arcos del Mar Menor, San Javier, 30739 Murcia, Spain
Article Number: 48
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Published online on: December 23, 2021

https://doi.org/10.3892/mco.2021.2481
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Abstract

Sinonasal small cell carcinoma (SmCC) is a rare type of neoplasm. The current case report describes the case of a 30‑year‑old male patient with stage IV SmCC who underwent concurrent radiotherapy (RT) plus etoposide‑cisplatin treatment. Positron emission tomography (PET)/computed tomography (CT) and fibroscopy examination showed complete remission at 3 months post‑treatment. However, leptomeningeal metastasis (LM) occurred at 9 months. A literature search identified no previous case reports describing LM of SmCC. The patient was treated with concurrent RT plus irinotecan‑gemcitabine. During the sixth cycle of irinotecan‑gemcitabine, the patient required intensive care admission due to severe acute respiratory syndrome‑related coronavirus 2‑associated pneumonia. Following clearance of the pneumonia, LM was assessed using PET/CT and MRI at 3 months, which revealed a complete response to irinotecan‑gemcitabine. In May 2021, the patient succumbed to LM following disease recurrence. The findings of this case report should encourage other authors to publish their treatment outcomes regarding SmCC. More clinical trials are required to achieve better results in terms of patient outcome.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Complete remission of stage IV sinonasal small cell neuroendocrine carcinoma: A case report

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Abstract

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