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Article

Epithelial‑to‑mesenchymal transition of circulating tumor cells and CD133 expression on predicting prognosis of thyroid cancer patients

  • Authors:
    • Deyu Li
    • Na Li
    • Ying Ding
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan 450003, P.R. China, Operating Room, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan 450003, P.R. China, Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China
  • Article Number: 141
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    Published online on: August 1, 2022
       https://doi.org/10.3892/mco.2022.2574
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Abstract

The present study aimed to explore the epithelial‑to‑mesenchymal transition of circulating tumor cells (CTCs) and CD133 expression in determining the prognosis of patients with thyroid cancer. It enumerated different CTC subtypes and analyzed CD133 gene expression in patients with thyroid cancer to evaluate the relationship between CTC number and thyroid cancer prognosis. In total 394 patients with thyroid cancer were enrolled. Among these, 270 cases had papillary thyroid cancer (PTC), 60 had follicular thyroid cancer (FTC), 30 had medullary thyroid cancer (MTC), 15 had poorly differentiated thyroid cancer, 19 had anaplastic thyroid cancer and 10 had non‑malignant thyroid nodules based on their histopathological characteristics. CTC cell counts were determined by CanPatrol CTC capture technique before treatment. The present study also performed reverse transcription‑quantitative PCR for CD133 gene expression and evaluated the relationship between CD133 expression and clinical pathology. A total of 330 cases of enrolled patients were classified as differentiated thyroid cancer, which included PTC and FTC. Their prognosis was excellent. The positivity rate of CTCs at diagnosis was 95.5%. The data of the present study showed that early recurrence and metastasis rates in PTC and FTC patients with >6 CTCs and positive mesenchymal circulating tumor cells (MCTCs) were significantly higher than those in patients with <6 CTCs and MCTCs. It was also found that those patients with >6 CTCs and MCTCs had shorter overall survival. In addition, CD133 levels in patients with thyroid cancer were strongly associated with the differentiation grades of thyroid cancers. The detection of >6 CTCs and positive MCTCs in patients with differentiated thyroid cancer was an excellent biomarker for predicting the prognosis of patients. CD133 expression was also identified as a good biomarker for thyroid cancer differentiation.
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1 

Tunbridge WM, Evered DC, Hall R, Appleton D, Brewis M, Clark F, Evans JG, Young E, Bird T and Smith PA: The spectrum of thyroid disease in a community: The Whickham survey. Clin Endocrinol (Oxf). 7:481–493. 1977.PubMed/NCBI View Article : Google Scholar

2 

Haugen BR: 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: What is new and what has changed? Cancer. 123:372–381. 2017.PubMed/NCBI View Article : Google Scholar

3 

Al-Hilli Z, Strajina V, McKenzie TJ, Thompson GB, Farley DR and Richards ML: The role of lateral neck ultrasound in detecting single or multiple lymph nodes in papillary thyroid cancer. Am J Surg. 212:1147–1153. 2016.PubMed/NCBI View Article : Google Scholar

4 

Jee HG, Kim BA, Kim M, Yu HW, Choi JY, Kim SJ and Lee KE: Expression of SLC5A5 in circulating tumor cells may distinguish follicular thyroid carcinomas from adenomas: Implications for blood-based preoperative diagnosis. J Clin Med. 8(257)2019.PubMed/NCBI View Article : Google Scholar

5 

Chin PD, Zhu CY, Sajed DP, Fishbein GA, Yeh MW, Leung AM and Livhits MJ: Correlation of ThyroSeq results with surgical histopathology in cytologically indeterminate thyroid nodules. Endocr Pathol. 31:377–384. 2020.PubMed/NCBI View Article : Google Scholar

6 

Nix P, Nicolaides A and Coatesworth AP: Thyroid cancer review 2: Management of differentiated thyroid cancers. Int J Clin Pract. 59:1459–1463. 2005.PubMed/NCBI View Article : Google Scholar

7 

Nix PA, Nicolaides A and Coatesworth AP: Thyroid cancer review 3: Management of medullary and undifferentiated thyroid cancer. Int J Clin Pract. 60:80–84. 2006.PubMed/NCBI View Article : Google Scholar

8 

Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, et al: Executive summary: Heart disease and stroke statistics-2012 update: A report from the American Heart Association. Circulation. 125:188–197. 2012.PubMed/NCBI View Article : Google Scholar

9 

Lamartina L, Grani G, Durante C and Filetti S: Recent advances in managing differentiated thyroid cancer. F1000Res. 7(86)2018.PubMed/NCBI View Article : Google Scholar

10 

Patrone R, Velotti N, Masone S, Conzo A, Flagiello L, Cacciatore C, Filardo M, Granata V, Izzo F, Testa D, et al: Management of low-risk thyroid cancers: Is active surveillance a valid option? A systematic review of the literature. J Clin Med. 10(3569)2021.PubMed/NCBI View Article : Google Scholar

11 

Capdevila J, Galofre JC, Grande E, Zafon Llopis C, Ramón Y, Cajal Asensio T, Navarro Gonzalez E, Jiménez-Fonseca P, Santamaría Sandi J, Gómez Sáez JM and Riesco Eizaguirre G: Consensus on the management of advanced radioactive iodine-refractory differentiated thyroid cancer on behalf of the Spanish society of endocrinology thyroid cancer working group (GTSEEN) and Spanish rare cancer working group (GETHI). Clin Transl Oncol. 19:279–287. 2017.PubMed/NCBI View Article : Google Scholar

12 

Barbet J, Campion L, Kraeber-Bodere F and Chatal JF: Group GTES. Prognostic impact of serum calcitonin and carcinoembryonic antigen doubling-times in patients with medullary thyroid carcinoma. J Clin Endocrinol Metab. 90:6077–6084. 2005.PubMed/NCBI View Article : Google Scholar

13 

Perros P, Boelaert K, Colley S, Evans C, Evans RM, Gerrard Ba G, Gilbert J, Harrison B, Johnson SJ, Giles TE, et al: Guidelines for the management of thyroid cancer. Clin Endocrinol (Oxf). 81 (Suppl 1):S1–S122. 2014.PubMed/NCBI View Article : Google Scholar

14 

Miyauchi A, Kudo T, Miya A, Kobayashi K, Ito Y, Takamura Y, Higashiyama T, Fukushima M, Kihara M, Inoue H, et al: Prognostic impact of serum thyroglobulin doubling-time under thyrotropin suppression in patients with papillary thyroid carcinoma who underwent total thyroidectomy. Thyroid. 21:707–716. 2011.PubMed/NCBI View Article : Google Scholar

15 

Aya-Bonilla CA, Morici M, Hong X, McEvoy AC, Sullivan RJ, Freeman J, Calapre L, Khattak MA, Meniawy T, Millward M, et al: Detection and prognostic role of heterogeneous populations of melanoma circulating tumour cells. Br J Cancer. 122:1059–1067. 2020.PubMed/NCBI View Article : Google Scholar

16 

Sawabata N, Nakamura T, Kawaguchi T, Watanabe T, Ouji NS, Ito T and Taniguchi S: Circulating tumor cells detected only after surgery for non-small cell lung cancer: Is it a predictor of recurrence? J Thorac Dis. 12:4623–4632. 2020.PubMed/NCBI View Article : Google Scholar

17 

Cohen SJ, Punt CJ, Iannotti N, Saidman BH, Sabbath KD, Gabrail NY, Picus J, Morse M, Mitchell E, Miller MC, et al: Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer. J Clin Oncol. 26:3213–3221. 2008.PubMed/NCBI View Article : Google Scholar

18 

de Bono JS, Scher HI, Montgomery RB, Parker C, Miller MC, Tissing H, Doyle GV, Terstappen LW, Pienta KJ and Raghavan D: Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer. Clin Cancer Res. 14:6302–6309. 2018.PubMed/NCBI View Article : Google Scholar

19 

Hayes DF, Cristofanilli M, Budd GT, Ellis MJ, Stopeck A, Miller MC, Matera J, Allard WJ, Doyle GV and Terstappen LW: Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival. Clin Cancer Res. 12:4218–4224. 2006.PubMed/NCBI View Article : Google Scholar

20 

Wang PX, Xu Y, Sun YF, Cheng JW, Zhou KQ, Wu SY, Hu B, Zhang ZF, Guo W, Cao Y, et al: Detection of circulating tumor cells enables early recurrence prediction in hepatocellular carcinoma patients undergoing liver transplantation. Liver Int. 41:562–573. 2021.PubMed/NCBI View Article : Google Scholar

21 

Micalizzi DS, Haber DA and Maheswaran S: Cancer metastasis through the prism of epithelial-to-mesenchymal transition in circulating tumor cells. Mol Oncol. 11:770–780. 2017.PubMed/NCBI View Article : Google Scholar

22 

Ehlers M, Allelein S, Schwarz F, Hautzel H, Kuebart A, Schmidt M, Haase M, Dringenberg T and Schott M: Increased numbers of circulating tumor cells in thyroid cancer patients. Horm Metab Res. 50:602–608. 2018.PubMed/NCBI View Article : Google Scholar

23 

Xu JY, Handy B, Michaelis CL, Waguespack SG, Hu MI, Busaidy N, Jimenez C, Cabanillas ME, Fritsche HA Jr, Cote GJ and Sherman SI: Detection and prognostic significance of circulating tumor cells in patients with metastatic thyroid cancer. J Clin Endocrinol Metab. 101:4461–4467. 2019.PubMed/NCBI View Article : Google Scholar

24 

Corbeil D, Fargeas CA and Huttner WB: Rat prominin, like its mouse and human orthologues, is a pentaspan membrane glycoprotein. Biochem Biophys Res Commun. 285:939–944. 2011.PubMed/NCBI View Article : Google Scholar

25 

Baker M: Cancer stem cells tracked. Nature. 488:13–14. 2012.PubMed/NCBI View Article : Google Scholar

26 

Decaussin-Petrucci M, Deladoey J, Hafdi-Nejjari Z, Sassolas G, Borson-Chazot F, Abu-Khudir R, Fusco A, Descotes F, Cournoyer S and Sartelet H: group of Pathologists of the Rhône Alpes Region. Expression of CD133 in differentiated thyroid cancer of young patients. J Clin Pathol. 68:434–440. 2015.PubMed/NCBI View Article : Google Scholar

27 

Wang ZL, Zhang P, Li HC, Yang XJ, Zhang YP, Li ZL, Xue L, Xue YQ, Li HL, Chen Q and Chong T: Dynamic changes of different phenotypic and genetic circulating tumor cells as a biomarker for evaluating the prognosis of RCC. Cancer Biol Ther. 20:505–512. 2019.PubMed/NCBI View Article : Google Scholar

28 

Li J, Liao Y, Ran Y, Wang G, Wu W, Qiu Y, Liu J, Wen N, Jing T, Wang H and Zhang S: Evaluation of sensitivity and specificity of CanPatrol™ technology for detection of circulating tumor cells in patients with non-small cell lung cancer. BMC Pulm Med. 20(274)2020.PubMed/NCBI View Article : Google Scholar

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

30 

Hassan S, Blick T, Williams ED and Thompson EW: Applications of RNA from circulating tumor cells. Front Biosci (Landmark Ed). 25:874–892. 2020.PubMed/NCBI View Article : Google Scholar

31 

Syahrani RA, Yunita E and Wanandi SI: Suppression of rotenone-treated human breast cancer stem cell survival using survivin inhibitor YM155 is associated to oxidative stress modulation. Asian Pac J Cancer Prev. 21:2631–2637. 2020.PubMed/NCBI View Article : Google Scholar

32 

Moon DH, Lindsay DP, Hong S and Wang AZ: Clinical indications for, and the future of, circulating tumor cells. Adv Drug Deliv Rev. 125:143–150. 2018.PubMed/NCBI View Article : Google Scholar

33 

Qiu ZL, Wei WJ, Sun ZK, Shen CT, Song HJ, Zhang XY, Zhang GQ, Chen XY and Luo QY: Circulating tumor cells correlate with clinicopathological features and outcomes in differentiated thyroid cancer. Cell Physiol Biochem. 48:718–730. 2018.PubMed/NCBI View Article : Google Scholar

34 

Topa J, Gresner P, Zaczek AJ and Markiewicz A: Breast cancer circulating tumor cells with mesenchymal features-an unreachable target? Cell Mol Life Sci. 79(81)2022.PubMed/NCBI View Article : Google Scholar

35 

Russo GI, Musso N, Romano A, Caruso G, Petralia S, Lanzano L, Broggi G and Camarda M: The role of dielectrophoresis for cancer diagnosis and prognosis. Cancers (Basel). 14(198)2021.PubMed/NCBI View Article : Google Scholar

36 

Satelli A, Batth I, Brownlee Z, Mitra A, Zhou S, Noh H, Rojas CR, Li H, Meng QH and Li S: EMT circulating tumor cells detected by cell-surface vimentin are associated with prostate cancer progression. Oncotarget. 8:49329–49337. 2017.PubMed/NCBI View Article : Google Scholar

37 

Hyun KA, Koo GB, Han H, Sohn J, Choi W, Kim SI, Jung HI and Kim YS: Epithelial-to-mesenchymal transition leads to loss of EpCAM and different physical properties in circulating tumor cells from metastatic breast cancer. Oncotarget. 7:24677–24687. 2016.PubMed/NCBI View Article : Google Scholar

38 

Li TT, Liu H, Li FP, Hu YF, Mou TY, Lin T, Yu J, Zheng L and Li GX: Evaluation of epithelial-mesenchymal transitioned circulating tumor cells in patients with resectable gastric cancer: Relevance to therapy response. World J Gastroenterol. 21:13259–13267. 2015.PubMed/NCBI View Article : Google Scholar

39 

Wang Y, Liu Y, Zhang L, Tong L, Gao Y, Hu F, Lin PP, Li B and Zhang T: Vimentin expression in circulating tumor cells (CTCs) associated with liver metastases predicts poor progression-free survival in patients with advanced lung cancer. J Cancer Res Clin Oncol. 145:2911–2920. 2019.PubMed/NCBI View Article : Google Scholar

40 

Vona G, Sabile A, Louha M, Sitruk V, Romana S, Schutze K, Capron F, Franco D, Pazzagli M, Vekemans M, et al: Isolation by size of epithelial tumor cells: A new method for the immunomorphological and molecular characterization of circulatingtumor cells. Am J Pathol. 156:57–63. 2000.PubMed/NCBI View Article : Google Scholar

41 

Riethdorf S, Fritsche H, Muller V, Rau T, Schindlbeck C, Rack B, Janni W, Coith C, Beck K, Jänicke F, et al: Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: A validation study of the CellSearch system. Clin Cancer Res. 13:920–928. 2017.PubMed/NCBI View Article : Google Scholar

42 

Qi LN, Xiang BD, Wu FX, Ye JZ, Zhong JH, Wang YY, Chen YY, Chen ZS, Ma L, Chen J, et al: Circulating tumor cells undergoing EMT provide a metric for diagnosis and prognosis of patients with hepatocellular carcinoma. Cancer Res. 78:4731–4744. 2018.PubMed/NCBI View Article : Google Scholar

43 

Marcuello M, Vymetalkova V, Neves RPL, Duran-Sanchon S, Vedeld HM, Tham E, van Dalum G, Flügen G, Garcia-Barberan V, Fijneman RJ, et al: Circulating biomarkers for early detection and clinical management of colorectal cancer. Mol Aspects Med. 69:107–122. 2019.PubMed/NCBI View Article : Google Scholar

44 

Allard WJ and Terstappen LW: CCR 20th anniversary commentary: Paving the way for circulating tumor cells. Clin Cancer Res. 21:2883–2885. 2015.PubMed/NCBI View Article : Google Scholar

45 

Tieng FYF, Baharudin R, Abu N, Mohd Yunos RI, Lee LH and Ab Mutalib NS: Single cell transcriptome in colorectal cancer-current updates on its application in metastasis, chemoresistance and the roles of circulating tumor cells. Front Pharmacol. 11(135)2020.PubMed/NCBI View Article : Google Scholar

46 

Hou JM, Krebs MG, Lancashire L, Sloane R, Backen A, Swain RK, Priest LJ, Greystoke A, Zhou C, Morris K, et al: Clinical significance and molecular characteristics of circulating tumor cells and circulating tumor microemboli in patients with small-cell lung cancer. J Clin Oncol. 30:525–532. 2012.PubMed/NCBI View Article : Google Scholar

47 

de Sousa e Melo F, Kurtova AV, Harnoss JM, Kljavin N, Hoeck JD, Hung J, Anderson JE, Storm EE, Modrusan Z, Koeppen H, et al: A distinct role for Lgr5(+) stem cells in primary and metastatic colon cancer. Nature. 543:676–680. 2017.PubMed/NCBI View Article : Google Scholar

48 

Cefalu AB, Giammanco A, Noto D, Spina R, Cabibi D, Barbagallo CM and Averna M: Effectiveness and safety of lomitapide in a patient with familial chylomicronemia syndrome. Endocrine. 71:344–350. 2020.PubMed/NCBI View Article : Google Scholar

49 

Proskurnina EV, Fedorova MV, Sozarukova MM, Mitichkin AE, Panteleev IV and Svetlov EV: Microsomal reductase activity in patients with thyroid neoplasms. Endocrine. 72:735–743. 2021.PubMed/NCBI View Article : Google Scholar

50 

Zou X, Gao F, Wang ZY, Zhang H, Liu QX, Jiang L, Zhou X and Zhu W: A three-microRNA panel in serum as novel biomarker for papillary thyroid carcinoma diagnosis. Chin Med J (Engl). 133:2543–2551. 2020.PubMed/NCBI View Article : Google Scholar

51 

Riegg F, Lutz MS, Schmied BJ, Heitmann JS, Queudeville M, Lang P, Jung G, Salih HR and Märklin M: An Fc-Optimized CD133 antibody for induction of NK cell reactivity against B cell acute lymphoblastic leukemia. Cancers (Basel). 13(1632)2021.PubMed/NCBI View Article : Google Scholar

52 

Liu Y, Yao X, Wang C, Wang M, Wang Y, Ye M and Liu Y: Peptide-based 68Ga-PET radiotracer for imaging CD133 expression in colorectal cancer. Nucl Med Commun. 42:1144–1150. 2021.PubMed/NCBI View Article : Google Scholar

53 

Acikgoz E, Mukhtarova G, Alpay A, Avci CB, Bagca BG and Oktem G: Sonic hedgehog signaling is associated with resistance to zoledronic acid in CD133high/CD44high prostate cancer stem cells. Mol Biol Rep. 48:3567–3578. 2021.PubMed/NCBI View Article : Google Scholar

54 

Ge MH, Zhu XH, Shao YM, Wang C, Huang P, Wang Y, Jiang Y, Maimaitiyiming Y, Chen E, Yang C and Naranmandura H: Synthesis and characterization of CD133 targeted aptamer-drug conjugates for precision therapy of anaplastic thyroid cancer. Biomater Sci. 9:1313–1324. 2021.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Li D, Li N and Ding Y: Epithelial‑to‑mesenchymal transition of circulating tumor cells and CD133 expression on predicting prognosis of thyroid cancer patients. Mol Clin Oncol 17: 141, 2022.
APA
Li, D., Li, N., & Ding, Y. (2022). Epithelial‑to‑mesenchymal transition of circulating tumor cells and CD133 expression on predicting prognosis of thyroid cancer patients. Molecular and Clinical Oncology, 17, 141. https://doi.org/10.3892/mco.2022.2574
MLA
Li, D., Li, N., Ding, Y."Epithelial‑to‑mesenchymal transition of circulating tumor cells and CD133 expression on predicting prognosis of thyroid cancer patients". Molecular and Clinical Oncology 17.3 (2022): 141.
Chicago
Li, D., Li, N., Ding, Y."Epithelial‑to‑mesenchymal transition of circulating tumor cells and CD133 expression on predicting prognosis of thyroid cancer patients". Molecular and Clinical Oncology 17, no. 3 (2022): 141. https://doi.org/10.3892/mco.2022.2574
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Spandidos Publications style
Li D, Li N and Ding Y: Epithelial‑to‑mesenchymal transition of circulating tumor cells and CD133 expression on predicting prognosis of thyroid cancer patients. Mol Clin Oncol 17: 141, 2022.
APA
Li, D., Li, N., & Ding, Y. (2022). Epithelial‑to‑mesenchymal transition of circulating tumor cells and CD133 expression on predicting prognosis of thyroid cancer patients. Molecular and Clinical Oncology, 17, 141. https://doi.org/10.3892/mco.2022.2574
MLA
Li, D., Li, N., Ding, Y."Epithelial‑to‑mesenchymal transition of circulating tumor cells and CD133 expression on predicting prognosis of thyroid cancer patients". Molecular and Clinical Oncology 17.3 (2022): 141.
Chicago
Li, D., Li, N., Ding, Y."Epithelial‑to‑mesenchymal transition of circulating tumor cells and CD133 expression on predicting prognosis of thyroid cancer patients". Molecular and Clinical Oncology 17, no. 3 (2022): 141. https://doi.org/10.3892/mco.2022.2574
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