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Article Open Access

Causal relationship between gut microbiota and gastric cancer: A two‑sample Mendelian randomization analysis

  • Authors:
    • Jianling Zhang
    • Chunlu Dong
    • Yanyan Lin
    • Lifeng Shang
    • Junming Ma
    • Ruiping Hu
    • Hejing Wang
  • View Affiliations / Copyright

    Affiliations: General Surgery Ward 5, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China, General Surgery Ward 3, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China, Department of General Surgery, Qingdao Eighth People's Hospital, Qingdao, Shandong 266000, P.R. China, Department of General Surgery, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, Ningxia 750000, P.R. China, Department of Endocrinology, The Third People's Hospital of Gansu Province, Lanzhou, Gansu 730000, P.R. China, Department of Healthcare‑Associated Infection Control, The Third People's Hospital of Gansu Province, Lanzhou, Gansu 730000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 38
    |
    Published online on: April 2, 2024
       https://doi.org/10.3892/mco.2024.2736
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Abstract

The gut microbiota is associated with GC; however, the causal association between the gut microbiota and GC remains to be determined. The aim of the present study was to investigate the causal association between gut microbiota and gastric cancer (GC) from the perspective of Mendelian randomization (MR). The present study performed MR analysis using summary statistics from a genome‑wide association study of the gut microbiome and GC. Inverse‑variance weighted, MR‑Egger and weighted median methods were used to investigate the causal relationship between gut microbiota and GC. Heterogeneity tests were performed using Cochrane's Q statistic. Horizontal polytropy was detected using Mendelian Randomization Pleiotropy RESidual Sum and Outlier were eliminated. Estimates from MR indicated that nine gut microorganism remained stable with regard to acceptance of heterogeneity and sensitivity methods. Among them, the genera Prevotella 7, Roseburia and Ruminococcaceae UCG014 were associated with an increased risk of GC; by contrast, the family Enterobacteriaceae, the genera Allisonella, Lachnospiraceae FCS020, Ruminococcaceae UCG004 and Ruminococcaceae UCG009, and the order Enterobacteriales decreased the risk of GC development. The present study demonstrated the potential importance of modulating the abundance of gut microbiota for the prevention and treatment of GC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Dong C, Lin Y, Shang L, Ma J, Hu R and Wang H: Causal relationship between gut microbiota and gastric cancer: A two‑sample Mendelian randomization analysis. Mol Clin Oncol 20: 38, 2024.
APA
Zhang, J., Dong, C., Lin, Y., Shang, L., Ma, J., Hu, R., & Wang, H. (2024). Causal relationship between gut microbiota and gastric cancer: A two‑sample Mendelian randomization analysis. Molecular and Clinical Oncology, 20, 38. https://doi.org/10.3892/mco.2024.2736
MLA
Zhang, J., Dong, C., Lin, Y., Shang, L., Ma, J., Hu, R., Wang, H."Causal relationship between gut microbiota and gastric cancer: A two‑sample Mendelian randomization analysis". Molecular and Clinical Oncology 20.5 (2024): 38.
Chicago
Zhang, J., Dong, C., Lin, Y., Shang, L., Ma, J., Hu, R., Wang, H."Causal relationship between gut microbiota and gastric cancer: A two‑sample Mendelian randomization analysis". Molecular and Clinical Oncology 20, no. 5 (2024): 38. https://doi.org/10.3892/mco.2024.2736
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Dong C, Lin Y, Shang L, Ma J, Hu R and Wang H: Causal relationship between gut microbiota and gastric cancer: A two‑sample Mendelian randomization analysis. Mol Clin Oncol 20: 38, 2024.
APA
Zhang, J., Dong, C., Lin, Y., Shang, L., Ma, J., Hu, R., & Wang, H. (2024). Causal relationship between gut microbiota and gastric cancer: A two‑sample Mendelian randomization analysis. Molecular and Clinical Oncology, 20, 38. https://doi.org/10.3892/mco.2024.2736
MLA
Zhang, J., Dong, C., Lin, Y., Shang, L., Ma, J., Hu, R., Wang, H."Causal relationship between gut microbiota and gastric cancer: A two‑sample Mendelian randomization analysis". Molecular and Clinical Oncology 20.5 (2024): 38.
Chicago
Zhang, J., Dong, C., Lin, Y., Shang, L., Ma, J., Hu, R., Wang, H."Causal relationship between gut microbiota and gastric cancer: A two‑sample Mendelian randomization analysis". Molecular and Clinical Oncology 20, no. 5 (2024): 38. https://doi.org/10.3892/mco.2024.2736
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