Open Access

Targeting of nucleo‑cytoplasmic transport factor exportin 1 in malignancy (Review)

  • Authors:
    • Sibel Özdaş
    • İpek Canatar
  • View Affiliations

  • Published online on: December 28, 2021     https://doi.org/10.3892/mi.2021.27
  • Article Number: 2
  • Copyright : © Özdaş et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Nuclear pore complexes (NPCs) regulate the entry and exit of molecules from the cell nucleus. Small molecules pass through NPCs by diffusion while large molecules enter and exit the nucleus by karyopherins, which serve as transport factors. Exportin‑1 (XPO1) is a protein that is an important member of the karyopherin family and carries macromolecules from the nucleus to the cytoplasm. XPO1 is responsible for nuclear‑cytoplasmic transport of protein, ribosomal RNA and certain required mRNAs for ribosomal biogenesis. Furthermore, XPO1‑mediated nuclear export is associated with various types of disease, such as cancer, inflammation and viral infection. The key role of XPO1 in carcinogenesis and its potential as a therapeutic target has been demonstrated by previous studies. Clinical use of novel developed generation‑specific XPO1 inhibitors and their combination with other agents to block XPO1‑mediated nuclear export are a promising new treatment strategy. The aim of the present study was to explain the working mechanism of XPO1 and inhibitors that block XPO1‑mediated nuclear export.
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January-February 2022
Volume 2 Issue 1

Print ISSN: 2754-3242
Online ISSN:2754-1304

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Spandidos Publications style
Özdaş S and Özdaş S: Targeting of nucleo‑cytoplasmic transport factor exportin 1 in malignancy (Review). Med Int 2: 2, 2022
APA
Özdaş, S., & Özdaş, S. (2022). Targeting of nucleo‑cytoplasmic transport factor exportin 1 in malignancy (Review). Medicine International, 2, 2. https://doi.org/10.3892/mi.2021.27
MLA
Özdaş, S., Canatar, I."Targeting of nucleo‑cytoplasmic transport factor exportin 1 in malignancy (Review)". Medicine International 2.1 (2022): 2.
Chicago
Özdaş, S., Canatar, I."Targeting of nucleo‑cytoplasmic transport factor exportin 1 in malignancy (Review)". Medicine International 2, no. 1 (2022): 2. https://doi.org/10.3892/mi.2021.27