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Molecular Medicine Reports
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Article

Angiotensinogen gene M235T polymorphism and risk of coronary artery disease: A meta-analysis

  • Authors:
    • Yu-Jing Wang
    • Yan Pan
  • View Affiliations / Copyright

    Affiliations: Cardiovascular Department, The First Affiliated Hospital of Yangtze University, Medical College of Yangtze University, Shashi District, Jingzhou, Hubei 434000, P.R. China, Department of Pediatrics, The First Affiliated Hospital of Yangtze University, Medical College of Yangtze University, Shashi District, Jingzhou, Hubei 434000, P.R. China
  • Pages: 884-888
    |
    Published online on: July 27, 2012
       https://doi.org/10.3892/mmr.2012.1011
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Abstract

The angiotensinogen (AGT) gene M235T polymorphism has been suggested to be linked with susceptibility to coronary artery disease (CAD). In the present study, a meta-analysis was performed to assess the correlation between the M235T polymorphism and CAD. Nine studies with a total of 2281 subjects were selected for inclusion in the analysis. The references were retrieved via PubMed, China National Knowledge Infrastructure, Wanfang and VIP database (1995.1‑2012.1). The analyses were performed using STATA 10.0 software. Odds ratios (OR) with 95% confidence intervals (CIs) were assessed after the collected data were pooled for analysis. A significant association was detected between M235T gene polymorphism and CAD in the population studied. The estimates (OR) of CAD risk were calculated in a homozygote comparison (OR=1.54; 95% CI, 1.09-2.16), a heterozygote comparison (OR=1.30; 95% CI, 1.07-1.58), a dominant model (OR=0.72; 95% CI, 0.55-0.94) and a recessive model (OR=1.37; 95% CI, 0.98-1.91). The current meta-analysis suggests that the M235T polymorphism is associated to an increased risk of CAD.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y and Pan Y: Angiotensinogen gene M235T polymorphism and risk of coronary artery disease: A meta-analysis. Mol Med Rep 6: 884-888, 2012.
APA
Wang, Y., & Pan, Y. (2012). Angiotensinogen gene M235T polymorphism and risk of coronary artery disease: A meta-analysis. Molecular Medicine Reports, 6, 884-888. https://doi.org/10.3892/mmr.2012.1011
MLA
Wang, Y., Pan, Y."Angiotensinogen gene M235T polymorphism and risk of coronary artery disease: A meta-analysis". Molecular Medicine Reports 6.4 (2012): 884-888.
Chicago
Wang, Y., Pan, Y."Angiotensinogen gene M235T polymorphism and risk of coronary artery disease: A meta-analysis". Molecular Medicine Reports 6, no. 4 (2012): 884-888. https://doi.org/10.3892/mmr.2012.1011
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y and Pan Y: Angiotensinogen gene M235T polymorphism and risk of coronary artery disease: A meta-analysis. Mol Med Rep 6: 884-888, 2012.
APA
Wang, Y., & Pan, Y. (2012). Angiotensinogen gene M235T polymorphism and risk of coronary artery disease: A meta-analysis. Molecular Medicine Reports, 6, 884-888. https://doi.org/10.3892/mmr.2012.1011
MLA
Wang, Y., Pan, Y."Angiotensinogen gene M235T polymorphism and risk of coronary artery disease: A meta-analysis". Molecular Medicine Reports 6.4 (2012): 884-888.
Chicago
Wang, Y., Pan, Y."Angiotensinogen gene M235T polymorphism and risk of coronary artery disease: A meta-analysis". Molecular Medicine Reports 6, no. 4 (2012): 884-888. https://doi.org/10.3892/mmr.2012.1011
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