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November 2012 Volume 6 Issue 5

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Article

Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9 in vitro

  • Authors:
    • Xiao-Man Xu
    • Yi Zhang
    • Dan Qu
    • Xue-Wei Feng
    • Yu Chen
    • Li Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Department of Geriatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China
  • Pages: 1018-1022
    |
    Published online on: August 21, 2012
       https://doi.org/10.3892/mmr.2012.1044
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Abstract

Osthole, a natural compound, may be extracted from Cnidium monnieri and other medicinal plants. Previous studies have shown that osthole has anticancer effects in various human cancer cell lines. There is, however, no available information concerning the effects of osthole on the migration and invasion of human lung cancer cells. In the current study, we used Transwell assays to demonstrate that osthole inhibited the migration and invasion of A549 human lung cancer cells. Western blot analysis revealed that osthole reduced the levels of matrix metalloproteinase-2 (MMP-2) and matrix metallopeptidase-9 (MMP-9) in the A549 human lung cancer cells. Our findings indicate that osthole may have a novel function as an inhibitor of the metastasis of human lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Xu X, Zhang Y, Qu D, Feng X, Chen Y and Zhao L: Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9 in vitro. Mol Med Rep 6: 1018-1022, 2012.
APA
Xu, X., Zhang, Y., Qu, D., Feng, X., Chen, Y., & Zhao, L. (2012). Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9 in vitro. Molecular Medicine Reports, 6, 1018-1022. https://doi.org/10.3892/mmr.2012.1044
MLA
Xu, X., Zhang, Y., Qu, D., Feng, X., Chen, Y., Zhao, L."Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9 in vitro". Molecular Medicine Reports 6.5 (2012): 1018-1022.
Chicago
Xu, X., Zhang, Y., Qu, D., Feng, X., Chen, Y., Zhao, L."Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9 in vitro". Molecular Medicine Reports 6, no. 5 (2012): 1018-1022. https://doi.org/10.3892/mmr.2012.1044
Copy and paste a formatted citation
x
Spandidos Publications style
Xu X, Zhang Y, Qu D, Feng X, Chen Y and Zhao L: Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9 in vitro. Mol Med Rep 6: 1018-1022, 2012.
APA
Xu, X., Zhang, Y., Qu, D., Feng, X., Chen, Y., & Zhao, L. (2012). Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9 in vitro. Molecular Medicine Reports, 6, 1018-1022. https://doi.org/10.3892/mmr.2012.1044
MLA
Xu, X., Zhang, Y., Qu, D., Feng, X., Chen, Y., Zhao, L."Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9 in vitro". Molecular Medicine Reports 6.5 (2012): 1018-1022.
Chicago
Xu, X., Zhang, Y., Qu, D., Feng, X., Chen, Y., Zhao, L."Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9 in vitro". Molecular Medicine Reports 6, no. 5 (2012): 1018-1022. https://doi.org/10.3892/mmr.2012.1044
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