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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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December 2012 Volume 6 Issue 6

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Article

Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression

  • Authors:
    • Xiao-Dong Sun
    • Xing-E Liu
    • Dong-Sheng Huang
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary and Pancreatic Surgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China , Department of Medical Oncology, Zhejiang Hospital, Hangzhou, Zhejiang 310013, P.R. China
  • Pages: 1267-1270
    |
    Published online on: September 26, 2012
       https://doi.org/10.3892/mmr.2012.1103
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Abstract

Curcumin is the major component of the spice turmeric, extracted from the rhizomes of the plant Curcuma longa. It exerts a number of therapeutic effects, including the inhibition of cancer cell proliferation. However, the anti‑carcinogenic mechanism of curcumin has not been fully elucidated. Triple-negative breast cancer (TNBC), which lacks expression of the estrogen receptor (ER), progesterone receptor (PR) and epidermal growth factor receptor 2 (HER2/EGFR2), is an aggressive breast cancer phenotype with a poor prognosis. In this study, we investigated the effects of curcumin on triple-negative breast cancer cells and the possible molecular mechanisms. The MDA-MB-231 TNBC cells were treated with curcumin, the growth inhibition ratio of the cells was measured by MTT assay, apoptosis was detected by flow cytometry and the expression levels of extracellular regulated protein kinase (ERK1/2), pERK1/2, EGFR and pEGFR were detected by western blotting. After treatment with different concentrations of curcumin, the growth inhibition rates of the MDA-MB-231 breast cancer cells of the 30 µmol/ml curcumin-treated group were significantly different from those of the other groups. The level of apoptosis of the curcumin‑treated group (26.34%) was significantly different from that of the control group (2.76%). The expression levels of pERK1/2 and pEGFR in the curcumin-treated group were significantly decreased compared with those of the control group. These results indicate that curcumin is able to inhibit the proliferation of TNBC cells. Inhibition of the EGFR signaling pathway is the likely underlying molecular mechanism.
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1 

Goel A and Aggarwal BB: Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutr Cancer. 62:919–930. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Basnet P and Skalko-Basnet N: Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules. 16:4567–4598. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Siziopikou KP, Ariga R, Proussaloglou KE, et al: The challenging estrogen receptor-negative/progesterone receptor-negative/HER-2-negative patient: a promising candidate for epidermal growth factor receptor-targeted therapy? Breast J. 12:360–362. 2006. View Article : Google Scholar

4 

De Ruijter TC, Veeck J, de Hoon JP, et al: Characteristics of triple-negative breast cancer. J Cancer Res Clin Oncol. 137:183–192. 2011.PubMed/NCBI

5 

Thike AA, Cheok PY, Jara-Lazaro AR, et al: Triple-negative breast cancer: clinicopathological characteristics and relationship with basal-like breast cancer. Mod Pathol. 23:123–133. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Tan DS, Marchió C, Jones RL, et al: Triple negative breast cancer: molecular profiling and prognostic impact in adjuvant anthracycline-treated patients. Breast Cancer Res Treat. 111:27–44. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Eralp Y, Derin D, Ozluk Y, et al: MAPK overexprssion is associated with anthracycline resistance and increased risk for recurrence in patients with triple-negative breast cancer. Ann Oncol. 19:669–674. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Wilken R, Veena MS, Wang MB and Srivatsan ES: Curcumin: a review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol Cancer. 10:12–31. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Reuter S, Eifes S, Dicato M, et al: Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells. Biochem Pharmacol. 76:1340–1351. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Kunnumakkara AB, Anand P and Aggarwal BB: Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett. 269:199–225. 2008. View Article : Google Scholar

11 

Rowe DL, Ozbay T, O’Regan RM and Nahta R: Modulation of the BRCA1 protein and induction of apoptosis in triple negative breast cancer cell lines by the polyphenolic compound curcumin. Breast Cancer (Auckland). 3:61–75. 2009.PubMed/NCBI

12 

Oiso S, Ikeda R, Nakamura K, et al: Involvement of NF-κB activation in the cisplatin resistance of human epidermoid carcinoma KCP-4 cells. Oncol Rep. 28:27–32. 2012.

13 

Chiu TL and Su CC: Curcumin inhibits proliferation and migration by increasing the Bax to Bcl-2 ratio and decreasing NFκBp65 expression in breast cancer MDA-MB-231 cells. Int J Mol Med. 23:469–475. 2009.PubMed/NCBI

14 

Chakraborty G, Jain S, Kale S, et al: Curcumin suppresses breast tumor angiogenesis by abrogating osteopontin-induced VEGF expression. Mol Med Report. 1:641–646. 2008.PubMed/NCBI

15 

Cui SX, Qu XJ, Xie YY, et al: Curcumin inhibits telomerase activity in human cancer cell lines. Int J Mol Med. 18:227–231. 2006.PubMed/NCBI

16 

Mimeault M and Batra SK: Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy. Chin Med. 6:312011. View Article : Google Scholar : PubMed/NCBI

17 

Hirose H, Ishii H, Mimori K, et al: Notch pathway as candidate therapeutic target in Her2/Neu/ErbB2 receptor-negative breast tumors. Oncol Rep. 23:35–43. 2010.PubMed/NCBI

18 

Lee JY, Lee YM, Chang GC, et al: Curcumin induces EGFR degradation in lung adenocarcinoma and modulates p38 activation in intestine: the versatile adjuvant for gefitinib therapy. PLoS One. 6:e237562011. View Article : Google Scholar : PubMed/NCBI

19 

Chadalapaka G, Jutooru I, Burghardt R and Safe S: Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells. Mol Cancer Res. 8:739–750. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Billar JA, Dueck AC, Stucky CC, et al: Triple-negative breast cancers: unique clinical presentations and outcomes. Ann Surg Oncol. 17(Suppl 3): 384–390. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Sutton LM, Han JS, Molberg KH, et al: Intratumoral expression level of epidermal growth factor receptor and cytokeratin 5/6 is significantly associated with nodal and distant metastases in patients with basal-like triple-negative breast carcinoma. Am J Clin Pathol. 134:782–787. 2010. View Article : Google Scholar

22 

Ueno NT and Zhang D: Targeting EGFR in triple negative breast cancer. J Cancer. 2:324–328. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Sánchez-Muñoz A, Gallego E, de Luque V, et al: Lack of evidence for KRAS oncogenic mutations in triple-negative breast cancer. BMC Cancer. 10:1362010.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sun X, Liu X and Huang D: Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression. Mol Med Rep 6: 1267-1270, 2012.
APA
Sun, X., Liu, X., & Huang, D. (2012). Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression. Molecular Medicine Reports, 6, 1267-1270. https://doi.org/10.3892/mmr.2012.1103
MLA
Sun, X., Liu, X., Huang, D."Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression". Molecular Medicine Reports 6.6 (2012): 1267-1270.
Chicago
Sun, X., Liu, X., Huang, D."Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression". Molecular Medicine Reports 6, no. 6 (2012): 1267-1270. https://doi.org/10.3892/mmr.2012.1103
Copy and paste a formatted citation
x
Spandidos Publications style
Sun X, Liu X and Huang D: Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression. Mol Med Rep 6: 1267-1270, 2012.
APA
Sun, X., Liu, X., & Huang, D. (2012). Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression. Molecular Medicine Reports, 6, 1267-1270. https://doi.org/10.3892/mmr.2012.1103
MLA
Sun, X., Liu, X., Huang, D."Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression". Molecular Medicine Reports 6.6 (2012): 1267-1270.
Chicago
Sun, X., Liu, X., Huang, D."Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression". Molecular Medicine Reports 6, no. 6 (2012): 1267-1270. https://doi.org/10.3892/mmr.2012.1103
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