Baicalein induces apoptosis via a mitochondrial-dependent caspase activation pathway in T24 bladder cancer cells

  • Authors:
    • Hong-Liang Li
    • Shu Zhang
    • Yuan Wang
    • Rong-Rui Liang
    • Jun Li
    • Peng An
    • Zi-Ming Wang
    • Jun Yang
    • Zong-Fang Li
  • View Affiliations

  • Published online on: October 9, 2012     https://doi.org/10.3892/mmr.2012.1123
  • Pages: 266-270
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Abstract

Recurrence of bladder cancer following transurethral resection of bladder tumor (TURBt) is an obstacle in clinical management. In the current study, we investigated the antitumor activity of baicalein, a Chinese herbal medicine, against T24 bladder cancer cells in vitro. Baicalein inhibited growth and caused G1/S arrest of the cell cycle in the T24 cells. Moreover, baicalein induced apoptosis via loss of mitochondrial transmembrane potential (ΔΨm), release of cytochrome c and activation of caspase-9 and caspase-3. Baicalein inhibited Akt phosphorylation, downregulated Bcl-2 expression and upregulated Bax expression, which in turn increased the ratio of Bax/Bcl-2. Our results demonstrate that baicalein repressed growth inhibition and induced apoptosis via loss of ΔΨm and activation of caspase-9 and caspase-3 in T24 bladder cancer cells, which indicates that baicalein may be an effective agent in the clinical management of bladder cancer.
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January 2013
Volume 7 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Li H, Zhang S, Wang Y, Liang R, Li J, An P, Wang Z, Yang J and Li Z: Baicalein induces apoptosis via a mitochondrial-dependent caspase activation pathway in T24 bladder cancer cells. Mol Med Rep 7: 266-270, 2013.
APA
Li, H., Zhang, S., Wang, Y., Liang, R., Li, J., An, P. ... Li, Z. (2013). Baicalein induces apoptosis via a mitochondrial-dependent caspase activation pathway in T24 bladder cancer cells. Molecular Medicine Reports, 7, 266-270. https://doi.org/10.3892/mmr.2012.1123
MLA
Li, H., Zhang, S., Wang, Y., Liang, R., Li, J., An, P., Wang, Z., Yang, J., Li, Z."Baicalein induces apoptosis via a mitochondrial-dependent caspase activation pathway in T24 bladder cancer cells". Molecular Medicine Reports 7.1 (2013): 266-270.
Chicago
Li, H., Zhang, S., Wang, Y., Liang, R., Li, J., An, P., Wang, Z., Yang, J., Li, Z."Baicalein induces apoptosis via a mitochondrial-dependent caspase activation pathway in T24 bladder cancer cells". Molecular Medicine Reports 7, no. 1 (2013): 266-270. https://doi.org/10.3892/mmr.2012.1123