Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
April 2012 Volume 5 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April 2012 Volume 5 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Role of liver X receptors in cholesterol efflux and inflammatory signaling (Review)

  • Authors:
    • Rongtao Zhu
    • Zhibing Ou
    • Xiongzhong Ruan
    • Jianping Gong
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, P.R. China, Center for Lipid Research, Chongqing Medical University, Chongqing 400016, P.R. China
  • Pages: 895-900
    |
    Published online on: January 17, 2012
       https://doi.org/10.3892/mmr.2012.758
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Liver X receptors (LXRs) are nuclear receptors that play a central role in cholesterol metabolism. When activated, LXRs induce a series of genes that are involved in cholesterol efflux, absorption, transport and excretion. In recent studies, LXRs have also been shown to play an important role in inflammatory signaling. LXR agonists show promise as potential therapeutics, given their anti-atherogenic and anti-inflammatory properties. The function of LXRs in cholesterol efflux and inflammatory signaling make them attractive as therapies for cardiovascular and inflammatory diseases.
View Figures

Figure 1

View References

1 

V LegryD CottelJ FerrièresAssociation between liver X receptor α gene polymorphisms and risk of metabolic syndrome in French populationsInt J Obes (Lond)324214282008

2 

BM StensonM RydénN VenteclefLiver X receptor (LXR) regulates human adipocyte lipolysisJ Biol Chem286370379201110.1074/jbc.M110.17949921030586

3 

TJ BerrodinQ ShenEM QuinetIdentification of 5α, 6α-epoxycholesterol as a novel modulator of liver X receptor activityMol Pharmacol78104610582010

4 

M Korach-AndréA ArcherRP BarrosBoth liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activityProc Natl Acad Sci USA108403408201121173252

5 

K MotoshimaT Noguchi-YachideK SugitaSeparation of α-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRα-selective antagonistsBioorg Med Chem17500150142009

6 

T YasudaD GrillotJT BillheimerTissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivoArterioscler Thromb Vasc Biol30781786201010.1161/ATVBAHA.109.19569320110577

7 

Q ShenY BaiKC ChangLiver X receptor-retinoid X receptor (LXR-RXR) heterodimer cistrome reveals coordination of LXR and AP1 signaling in keratinocytesJ Biol Chem2861455414563201110.1074/jbc.M110.16570421349840

8 

R LallS KuruvillaK PrüferLiver X receptor beta with mutations in the activation function-2 region is excluded from the nucleolusCell Biol Int33447452200910.1016/j.cellbi.2009.01.01519356704

9 

M NoshiroE UsuiT KawamotoMultiple mechanisms regulate circadian expression of the gene for cholesterol 7α-hydroxylase (Cyp7a), a key enzyme in hepatic bile acid biosynthesisJ Biol Rhythms22299311200717660447

10 

AS HenkelKA AndersonAM DeweyA chronic high-cholesterol diet paradoxically suppresses hepatic CYP7A1 expression in FVB/NJ miceJ Lipid Res52289298201110.1194/jlr.M01278121097822

11 

M SatoK SatoM FuruseChange in hepatic and plasma bile acid contents and its regulatory gene expression in the chicken embryoComp Biochem Physiol B Biochem Mol Biol150344347200810.1016/j.cbpb.2008.04.00318499494

12 

CR Wooton-KeeDJ CoyAT AthippozhyMechanisms for increased expression of cholesterol 7α-hydroxylase (Cyp7a1) in lactating ratsHepatology512772852010

13 

M Hozoji-InadaY MunehiraK NagaoLXRβ directly interacts with ABCA1 to promote HDL formation during acute cholesterol accumulationJ Biol Chem28620117201242011

14 

JJ DonkinS StukasV Hirsch-ReinshagenATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 miceJ Biol Chem2853414434154201010.1074/jbc.M110.108100

15 

A TsezouD IliopoulosKN MalizosImpaired expression of genes regulating cholesterol efflux in human osteoarthritic chondrocytesJ Orthop Res2810331039201020108316

16 

FD GenvigirAC RodriguesA CerdaEffects of lipid-lowering drugs on reverse cholesterol transport gene expressions in peripheral blood mononuclear and HepG2 cellsPharmacogenomics1112351246201010.2217/pgs.10.9320860464

17 

A AkramJ SchmeidlerP KatselIncreased expression of RXRα in dementia: an early harbinger for the cholesterol dyshomeostasis?Mol Neurodegener5362010

18 

EA HuwaitKR GreenowNN SinghA novel role for c-Jun N-terminal kinase and phosphoinositide 3-kinase in the liver X receptor-mediated induction of macrophage gene expressionCell Signal23542549201110.1016/j.cellsig.2010.11.00221070853

19 

JP MauldinMH NagelinAJ WojcikReduced expression of ATP-binding cassette transporter G1 increases cholesterol accumulation in macrophages of patients with type 2 diabetes mellitusCirculation11727852792200810.1161/CIRCULATIONAHA.107.741314

20 

CJ DelvecchioP BilanP NairLXR-induced reverse cholesterol transport in human airway smooth muscle is mediated exclusively by ABCA1Am J Physiol Lung Cell Mol Physiol295L949L957200810.1152/ajplung.90394.200818820007

21 

H WiersmaN NijstadJF de BoerLack of Abcg1 results in decreased plasma HDL cholesterol levels and increased biliary cholesterol secretion in mice fed a high cholesterol dietAtherosclerosis206141147200910.1016/j.atherosclerosis.2009.02.02219339012

22 

J EckerG LiebischW PatschThe conjugated linoleic acid isomer trans-9,trans-11 is a dietary occurring agonist of liver X receptor αBiochem Biophys Res Commun388660666200919682978

23 

DD BojanicPT TarrGD GaleDifferential expression and function of ABCG1 and ABCG4 during development and agingJ Lipid Res51169181201010.1194/M900250-JLR20019633360

24 

N WangL Yvan-CharvetD LütjohannATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brainFASEB J2210731082200810.1096/fj.07-9944com18039927

25 

EM Van StratenNC HuijkmanJF BallerPharmacological activation of LXR in utero directly influences ABC transporter expression and function in mice but does not affect adult cholesterol metabolismAm J Physiol Endocrinol Metab295E1341E1348200818840761

26 

H KusuharaY SugiyamaATP-binding cassette, subfamily G (ABCG family)Pflugers Arch453735744200710.1007/s00424-006-0134-x16983557

27 

NP HessvikMV BoekschotenMA BaltzersenLXRβ is the dominant LXR subtype in skeletal muscle regulating lipogenesis and cholesterol effluxAm J Physiol Endocrinol Metab298E602E6132010

28 

JM TaylorF BorthwickC BartholomewOverexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AICardiovasc Res86526534201010.1093/cvr/cvq015

29 

S ZhongAL MagnoloM SundaramNonsynonymous mutations within APOB in human familial hypobetalipoproteinemia: evidence for feedback inhibition of lipogenesis and postendoplasmic reticulum degradation of apolipoprotein BJ Biol Chem28564536464201010.1074/jbc.M109.060467

30 

S HonzumiA ShimaA HiroshimaLXRα regulates human CETP expression in vitro and in transgenic miceAtherosclerosis2121391452010

31 

F BriandM TréguierA AndréLiver X receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster modelJ Lipid Res51763770201010.1194/jlr.M00155219965597

32 

D LakomyC RébéAL SbernaLiver X receptor-mediated induction of cholesteryl ester transfer protein expression is selectively impaired in inflammatory macrophagesArterioscler Thromb Vasc Biol2919231929200910.1161/ATVBAHA.109.193201

33 

M Korach-AndréA ArcherC GabbiLiver-X Receptors regulate de novo lipogenesis in a tissue specific manner in C57Bl/6 female miceAm J Physiol Endocrinol Metab301E210E222201121521718

34 

I HongHS RhoDH KimActivation of LXRα induces lipogenesis in HaCaT cellsArch Pharm Res33144314492010

35 

HY KayWD KimSJ HwangNrf2 inhibits LXRα-dependent hepatic lipogenesis by competing with FXR for acetylase bindingAntioxid Redox Signal15213521462011

36 

K SatoT KamadaRegulation of bile acid, cholesterol, and fatty acid synthesis in chicken primary hepatocytes by different concentrations of T0901317, an agonist of liver X receptorsComp Biochem Physiol A Mol Integr Physiol158201206201110.1016/j.cbpa.2010.10.02821056113

37 

MP MorrowA GrantZ MujawarStimulation of the liver X receptor pathway inhibits HIV-1 replication via induction of ATP-binding cassette transporter A1Mol Pharmacol78215225201010.1124/mol.110.06502920479131

38 

D TöröcsikM BaráthS BenkoActivation of liver X receptor sensitizes human dendritic cells to inflammatory stimuliJ Immunol18454565465201020410489

39 

H KorfS Vander BekenM RomanoLiver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in miceJ Clin Invest11916261637200910.1172/JCI3528819436111

40 

C FontaineE RigamontiA NoharaLiver X receptor activation potentiates the lipopolysaccharide response in human macrophagesCirc Res1014049200710.1161/CIRCRESAHA.106.13581417540978

41 

W HuangS GhislettiK SaijoCoronin 2A mediates actin-dependent de-repression of inflammatory response genesNature470414418201110.1038/nature0970321331046

42 

S ChenR SorrentinoK ShimadaChlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and independent signaling and is reciprocally modulated by liver X receptor activationJ Immunol18171867193200810.4049/jimmunol.181.10.7186

43 

D TerwelKR SteffensenPB VergheseCritical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosisJ Neurosci3170497059201121562267

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhu R, Ou Z, Ruan X and Gong J: Role of liver X receptors in cholesterol efflux and inflammatory signaling (Review). Mol Med Rep 5: 895-900, 2012.
APA
Zhu, R., Ou, Z., Ruan, X., & Gong, J. (2012). Role of liver X receptors in cholesterol efflux and inflammatory signaling (Review). Molecular Medicine Reports, 5, 895-900. https://doi.org/10.3892/mmr.2012.758
MLA
Zhu, R., Ou, Z., Ruan, X., Gong, J."Role of liver X receptors in cholesterol efflux and inflammatory signaling (Review)". Molecular Medicine Reports 5.4 (2012): 895-900.
Chicago
Zhu, R., Ou, Z., Ruan, X., Gong, J."Role of liver X receptors in cholesterol efflux and inflammatory signaling (Review)". Molecular Medicine Reports 5, no. 4 (2012): 895-900. https://doi.org/10.3892/mmr.2012.758
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu R, Ou Z, Ruan X and Gong J: Role of liver X receptors in cholesterol efflux and inflammatory signaling (Review). Mol Med Rep 5: 895-900, 2012.
APA
Zhu, R., Ou, Z., Ruan, X., & Gong, J. (2012). Role of liver X receptors in cholesterol efflux and inflammatory signaling (Review). Molecular Medicine Reports, 5, 895-900. https://doi.org/10.3892/mmr.2012.758
MLA
Zhu, R., Ou, Z., Ruan, X., Gong, J."Role of liver X receptors in cholesterol efflux and inflammatory signaling (Review)". Molecular Medicine Reports 5.4 (2012): 895-900.
Chicago
Zhu, R., Ou, Z., Ruan, X., Gong, J."Role of liver X receptors in cholesterol efflux and inflammatory signaling (Review)". Molecular Medicine Reports 5, no. 4 (2012): 895-900. https://doi.org/10.3892/mmr.2012.758
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team