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Article

The amyloid-β isoform pattern in cerebrospinal fluid in familial PSEN1 M139T- and L286P-associated Alzheimer's disease

  • Authors:
    • Erik Portelius
    • Juan Fortea
    • Jose Luis Molinuevo
    • Mikael K. Gustavsson
    • Ulf Andreasson
    • Raquel Sanchez-Valle
  • View Affiliations / Copyright

    Affiliations: Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden, Genetic Counseling Program for Familial Dementias, Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain
  • Pages: 1111-1115
    |
    Published online on: February 1, 2012
       https://doi.org/10.3892/mmr.2012.774
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Abstract

There are several familial forms of Alzheimer's disease (AD) most of which are caused by mutations in the genes that encode the presenilin enzymes involved in the production of amyloid-β (Aβ) from the amyloid precursor protein (APP). In AD, Aβ forms fibrils that are deposited in the brain as plaques. Much of the fibrillar Aβ found in the plaques consists of the 42 amino acid form of Aβ (Aβ1-42) and it is now widely accepted that Aβ is related to the pathogenesis of AD and that Aβ may both impair memory and be neurotoxic. In human cerebrospinal fluid (CSF) several C- and N-terminally truncated Aβ isoforms have been detected and their relative abundance pattern is thought to reflect the production and clearance of Aβ. By using immunoprecipitation and mass spectrometry, we have previously demonstrated that carriers of the familial AD (FAD)-associated PSEN1 A431E mutation have low CSF levels of C-terminally truncated Aβ isoforms shorter than Aβ1-40. Here we replicate this finding in symptomatic carriers of the FAD-causing PSEN1 L286P mutation. Furthermore, we show that preclinical carriers of the PSEN1 M139T mutation may overexpress Aβ1-42 suggesting that this particular mutation may cause AD by stimulating γ-secretase-mediated cleavage at amino acid 42 in the Aβ sequence.
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Copy and paste a formatted citation
Spandidos Publications style
Portelius E, Fortea J, Molinuevo JL, Gustavsson MK, Andreasson U and Sanchez-Valle R: The amyloid-β isoform pattern in cerebrospinal fluid in familial PSEN1 M139T- and L286P-associated Alzheimer's disease. Mol Med Rep 5: 1111-1115, 2012.
APA
Portelius, E., Fortea, J., Molinuevo, J.L., Gustavsson, M.K., Andreasson, U., & Sanchez-Valle, R. (2012). The amyloid-β isoform pattern in cerebrospinal fluid in familial PSEN1 M139T- and L286P-associated Alzheimer's disease. Molecular Medicine Reports, 5, 1111-1115. https://doi.org/10.3892/mmr.2012.774
MLA
Portelius, E., Fortea, J., Molinuevo, J. L., Gustavsson, M. K., Andreasson, U., Sanchez-Valle, R."The amyloid-β isoform pattern in cerebrospinal fluid in familial PSEN1 M139T- and L286P-associated Alzheimer's disease". Molecular Medicine Reports 5.4 (2012): 1111-1115.
Chicago
Portelius, E., Fortea, J., Molinuevo, J. L., Gustavsson, M. K., Andreasson, U., Sanchez-Valle, R."The amyloid-β isoform pattern in cerebrospinal fluid in familial PSEN1 M139T- and L286P-associated Alzheimer's disease". Molecular Medicine Reports 5, no. 4 (2012): 1111-1115. https://doi.org/10.3892/mmr.2012.774
Copy and paste a formatted citation
x
Spandidos Publications style
Portelius E, Fortea J, Molinuevo JL, Gustavsson MK, Andreasson U and Sanchez-Valle R: The amyloid-β isoform pattern in cerebrospinal fluid in familial PSEN1 M139T- and L286P-associated Alzheimer's disease. Mol Med Rep 5: 1111-1115, 2012.
APA
Portelius, E., Fortea, J., Molinuevo, J.L., Gustavsson, M.K., Andreasson, U., & Sanchez-Valle, R. (2012). The amyloid-β isoform pattern in cerebrospinal fluid in familial PSEN1 M139T- and L286P-associated Alzheimer's disease. Molecular Medicine Reports, 5, 1111-1115. https://doi.org/10.3892/mmr.2012.774
MLA
Portelius, E., Fortea, J., Molinuevo, J. L., Gustavsson, M. K., Andreasson, U., Sanchez-Valle, R."The amyloid-β isoform pattern in cerebrospinal fluid in familial PSEN1 M139T- and L286P-associated Alzheimer's disease". Molecular Medicine Reports 5.4 (2012): 1111-1115.
Chicago
Portelius, E., Fortea, J., Molinuevo, J. L., Gustavsson, M. K., Andreasson, U., Sanchez-Valle, R."The amyloid-β isoform pattern in cerebrospinal fluid in familial PSEN1 M139T- and L286P-associated Alzheimer's disease". Molecular Medicine Reports 5, no. 4 (2012): 1111-1115. https://doi.org/10.3892/mmr.2012.774
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