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Article

Ilex kudingcha C.J. Tseng (Kudingcha) prevents HCl/ethanol‑induced gastric injury in Sprague‑Dawley rats

  • Authors:
    • Xin Zhao
    • Qiang Wang
    • Yu Qian
    • Jia-Le Song
  • View Affiliations / Copyright

    Affiliations: Department of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, P.R. China, Department of Food Science and Nutrition, Pusan National University, Busan 609-735, Republic of Korea
  • Pages: 1613-1616
    |
    Published online on: March 28, 2013
       https://doi.org/10.3892/mmr.2013.1402
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Abstract

Ilex kudingcha C.J. Tseng (kudingcha) is a traditional Chinese beverage widely consumed in East Asia. In the present study, the preventative effect of kudingcha on gastric injury was determined in Sprague‑Dawley (SD) rats. High concentrations of kudingcha were observed to reduce the levels of the serum proinflammatory cytokines, interleukin 6 (IL-6) and tumor necrosis factor‑α (TNF‑α), compared with low concentrations of kudingcha. Gastric secretion volumes were highest in control rats and reduced in the following order; 250, 500 and 1,000 mg/kg kudingcha‑treated and normal rats. The pH levels of gastric juice samples obtained from each group revealed the opposite correlation. Gastric injury levels in rats treated with kudingcha were identified to be significantly reduced, demonstrating its anti‑inflammatory properties. Administration of 1,000 mg/kg kudingcha (73.9%) by gavage was demonstrated to induce the highest inhibitory effect on gastric injury. Results of the current study indicate that kudingcha exhibits marked preventive effects on gastric injury.
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1 

Ye GS: Kuding Tea. Spec Econ Anim Plant. 5:262002.

2 

Sun Y, Xu WQ, Zhang WQ, Hu QH and Zeng XX: Optimizing the extraction of phenolic antioxidants from kudingcha made from Ilex kudingcha C.J. Tseng by using response surface methodology. Sep Purif Technol. 78:311–320. 2011. View Article : Google Scholar

3 

Bravo L, Goya L and Lecumberri E: LC/MS characterization of phenolic constituents of mate (Ilex paraguariensis, St. Hil) and its antioxidant activity compared to commonly consumed beverages. Food Res Int. 40:393–405. 2007.

4 

Filip R, López P, Giberti G, Coussio J and Ferraro G: Phenolic compounds in seven South American Ilex species. Fitoterapia. 72:774–778. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Nakajima Y, Shimazawa M, Mishima S and Hara H: Water extract of propolis and its main constituents, caffeoylquinic acid derivatives, exert neuroprotective effects via antioxidant actions. Life Sci. 80:370–377. 2007. View Article : Google Scholar

6 

Han J, Miyamae Y, Shigemori H and Isoda H: Neuroprotective effect of 3,5-di-O-caffeoylquinic acid on SH-SY5Y cells and senescence-accelerated-prone mice 8 through the up-regulation of phosphoglycerate kinase-1. Neuroscience. 169:1039–1045. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Szabo S, Trier JS, Brown A and Schnoor J: Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology. 88:228–236. 1985. View Article : Google Scholar : PubMed/NCBI

8 

Medeiros JV, Gadelha GG, Lima SJ, Garcia JA, Soares PM, Santos AA, Brito GA, Ribeiro RA and Souza MH: Role of the NO/cGMP/K(ATP) pathway in the protective effects of sildenafil against ethanol-induced gastric damage in rats. Br J Pharmacol. 153:721–727. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Ramadori G and Armbrust T: Cytokines in the liver. Eur J Gastroenterol Hepatol. 13:777–784. 2001. View Article : Google Scholar : PubMed/NCBI

10 

McCurry KR, Campbell DA Jr, Scales WE, Warren JS and Remick DG: Tumor necrosis factor, interleukin 6, and the acute phase response following hepatic ischemia/reperfusion. J Surg Res. 55:49–54. 1993. View Article : Google Scholar : PubMed/NCBI

11 

Ming WJ, Bersani L and Mantovani A: Tumor necrosis factor is chemotactic for monocytes and polymorphonuclear leukocytes. J Immunol. 138:1469–1474. 1987.PubMed/NCBI

12 

Park HS, Park JY and Yu R: Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6. Diabetes Res Clin Pract. 69:29–35. 2005.

13 

Wang WL and Wang SJ: Healthcare effects and development prospects of Ilex kudingcha. Beverage Ind. 11:12–13. 2008.(In Chinese).

14 

Wang Z, Meng TB, Mei SM and Xiao CY: The biological characteristics of Malus sieboldfi(Rege1) Rehd - Kudingcha and its exploitation. Guiding J TCM. 12:90–91. 2006.(In Chinese).

15 

Gratacós J, Collado A, Filella X, Sanmartí R, Cañete J, Llena J, Molina R, Ballesta A and Muñoz-Gómez J: Serum cytokines (IL-6, TNF-α, IL-1β and IFN-γ) in ankylosing spondylitis: a close correlation between serum IL-6 and disease activity and severity. Br J Rheumatol. 33:927–931. 1994.

16 

Ferguson-Smith AC, Chen YF, Newman MS, May LT, Sehgal PB and Ruddle FH: Regional localization of the interferon-beta 2/B-cell stimulatory factor 2/hepatocyte stimulating factor gene to human chromosome 7p15–p21. Genomics. 2:203–208. 1988.PubMed/NCBI

17 

van der Poll T, Keogh CV, Guirao X, Buurman WA, Kopf M and Lowry SF: Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia. J Infect Dis. 176:439–444. 1997.PubMed/NCBI

18 

Gosselin D and Rivest S: Role of IL-1 and TNF in the brain: twenty years of progress on a Dr. Jekyll/Mr Hyde duality of the innate immune system. Brain Behav Immun. 21:281–289. 2007.PubMed/NCBI

19 

Abdollahi H, Shams S, Zahedi MJ, Darvish Moghadam S, Hayatbakhsh MM and Jafarzadeh A: IL-10, TNF-α and IFN-γ levels in serum and stomach mucosa of Helicobacter pylori-infected patients. Iran J Allergy Asthma Immunol. 10:267–271. 2011.

20 

Gislason H, Røkke O and Svanes K: Release of cytokines associated with gastric mucosal injury. Eur Surg Res. 28:278–286. 1996. View Article : Google Scholar : PubMed/NCBI

21 

Kuzuhara T, Suganuma M, Oka K and Fujiki H: DNA-binding activity of TNF-alpha inducing protein from Helicobacter pylori. Biochem Biophys Res Commun. 362:805–810. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Ku CS and Mun SP: Antioxidant activities of ethanol extracts from seeds in fresh Bokbunja (Rubus coreanus Miq.) and wine processing waste. Bioresour Technol. 99:4503–4509. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao X, Wang Q, Qian Y and Song J: Ilex kudingcha C.J. Tseng (Kudingcha) prevents HCl/ethanol‑induced gastric injury in Sprague‑Dawley rats. Mol Med Rep 7: 1613-1616, 2013.
APA
Zhao, X., Wang, Q., Qian, Y., & Song, J. (2013). Ilex kudingcha C.J. Tseng (Kudingcha) prevents HCl/ethanol‑induced gastric injury in Sprague‑Dawley rats. Molecular Medicine Reports, 7, 1613-1616. https://doi.org/10.3892/mmr.2013.1402
MLA
Zhao, X., Wang, Q., Qian, Y., Song, J."Ilex kudingcha C.J. Tseng (Kudingcha) prevents HCl/ethanol‑induced gastric injury in Sprague‑Dawley rats". Molecular Medicine Reports 7.5 (2013): 1613-1616.
Chicago
Zhao, X., Wang, Q., Qian, Y., Song, J."Ilex kudingcha C.J. Tseng (Kudingcha) prevents HCl/ethanol‑induced gastric injury in Sprague‑Dawley rats". Molecular Medicine Reports 7, no. 5 (2013): 1613-1616. https://doi.org/10.3892/mmr.2013.1402
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao X, Wang Q, Qian Y and Song J: Ilex kudingcha C.J. Tseng (Kudingcha) prevents HCl/ethanol‑induced gastric injury in Sprague‑Dawley rats. Mol Med Rep 7: 1613-1616, 2013.
APA
Zhao, X., Wang, Q., Qian, Y., & Song, J. (2013). Ilex kudingcha C.J. Tseng (Kudingcha) prevents HCl/ethanol‑induced gastric injury in Sprague‑Dawley rats. Molecular Medicine Reports, 7, 1613-1616. https://doi.org/10.3892/mmr.2013.1402
MLA
Zhao, X., Wang, Q., Qian, Y., Song, J."Ilex kudingcha C.J. Tseng (Kudingcha) prevents HCl/ethanol‑induced gastric injury in Sprague‑Dawley rats". Molecular Medicine Reports 7.5 (2013): 1613-1616.
Chicago
Zhao, X., Wang, Q., Qian, Y., Song, J."Ilex kudingcha C.J. Tseng (Kudingcha) prevents HCl/ethanol‑induced gastric injury in Sprague‑Dawley rats". Molecular Medicine Reports 7, no. 5 (2013): 1613-1616. https://doi.org/10.3892/mmr.2013.1402
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