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August 2013 Volume 8 Issue 2

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Article

miR-26a promotes neurite outgrowth by repressing PTEN expression

  • Authors:
    • Baoguo Li
    • Hanxiao Sun
  • View Affiliations / Copyright

    Affiliations: Institute of Genomic Medicine, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, P.R. China
  • Pages: 676-680
    |
    Published online on: June 19, 2013
       https://doi.org/10.3892/mmr.2013.1534
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Abstract

A multitude of studies have reported that microRNAs (miRNAs) are important in neuronal development. As a key regulator altering the expression of certain mRNAs, miR-26a has been demonstrated to play a role in the central nervous system (CNS). In the current study, the function of miR-26a in neuronal development was investigated. The overexpression of miR-26a was hypothesized to significantly enhance synaptic plasticity and regulate neuronal morphogenesis. The number and distribution of neurites was markedly increased by miR-26a. In addition, inhibition of miR-26a function attenuated neuronal outgrowth. Furthermore, phosphatase and tensin homolog (PTEN) was identified as a direct target of miR-26a in this process via a luciferase reporter assay. The growth of neurites was consistently suppressed by PTEN overexpression. Therefore, our study demonstrated that miR-26a promoted neurite outgrowth via the suppression of PTEN expression, indicating that miR-26a is important in neuronal development and morphogenesis. miR-26a has the potential to serve as a therapeutic target for patients with Alzheimer's disease (AD).
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Copy and paste a formatted citation
Spandidos Publications style
Li B and Sun H: miR-26a promotes neurite outgrowth by repressing PTEN expression. Mol Med Rep 8: 676-680, 2013.
APA
Li, B., & Sun, H. (2013). miR-26a promotes neurite outgrowth by repressing PTEN expression. Molecular Medicine Reports, 8, 676-680. https://doi.org/10.3892/mmr.2013.1534
MLA
Li, B., Sun, H."miR-26a promotes neurite outgrowth by repressing PTEN expression". Molecular Medicine Reports 8.2 (2013): 676-680.
Chicago
Li, B., Sun, H."miR-26a promotes neurite outgrowth by repressing PTEN expression". Molecular Medicine Reports 8, no. 2 (2013): 676-680. https://doi.org/10.3892/mmr.2013.1534
Copy and paste a formatted citation
x
Spandidos Publications style
Li B and Sun H: miR-26a promotes neurite outgrowth by repressing PTEN expression. Mol Med Rep 8: 676-680, 2013.
APA
Li, B., & Sun, H. (2013). miR-26a promotes neurite outgrowth by repressing PTEN expression. Molecular Medicine Reports, 8, 676-680. https://doi.org/10.3892/mmr.2013.1534
MLA
Li, B., Sun, H."miR-26a promotes neurite outgrowth by repressing PTEN expression". Molecular Medicine Reports 8.2 (2013): 676-680.
Chicago
Li, B., Sun, H."miR-26a promotes neurite outgrowth by repressing PTEN expression". Molecular Medicine Reports 8, no. 2 (2013): 676-680. https://doi.org/10.3892/mmr.2013.1534
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