Identification and analysis of microRNAs in the left ventricular myocardium of two-kidney one-clip hypertensive rats

Sun,Gang; Hu,Hai; Tian,Xuyang; Yue,Jianwei; Yu,Hui; Yang,Xiaomin; Wang,Zhanli

doi:10.3892/mmr.2013.1549

August 2013 Volume 8 Issue 2

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August 2013 Volume 8 Issue 2

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Article

Identification and analysis of microRNAs in the left ventricular myocardium of two-kidney one-clip hypertensive rats

Authors:
- Gang Sun
- Hai Hu
- Xuyang Tian
- Jianwei Yue
- Hui Yu
- Xiaomin Yang
- Zhanli Wang
View Affiliations / Copyright

Affiliations: Research Institute of Hypertension, Department of Cardiovascular Medicine, The Second Affiliated Hospital, Baotou Medical College, Baotou, Inner Mongolia Autonomous Region 014030, P.R. China, Department of Pathophysiology, Baotou Medical College, Baotou, Inner Mongolia Autonomous Region 014060, P.R. China, Department of Laboratory Centre, The First Affiliated Hospital, Baotou Medical College, Baotou, Inner Mongolia Autonomous Region 014010, P.R. China
Pages: 339-344
|
Published online on: June 25, 2013

https://doi.org/10.3892/mmr.2013.1549
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Abstract

MicroRNAs (miRNAs) are involved in the regulation of numerous physiological and pathological processes. However, little information is available with regard to miRNAs in the left ventricular myocardium of the renovascular angiotensin-dependent hypertensive rat. In this study, miRNA expression profiles in the left ventricular myocardium of two-kidney one-clip (2K1C) hypertensive rats were analyzed using a microarray. The roles of the differentially expressed miRNAs, their target genes and signaling pathways were analyzed using ingenuity pathway analysis (IPA) for the first time to further elucidate the molecular mechanisms of left ventricular remodeling.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Identification and analysis of microRNAs in the left ventricular myocardium of two-kidney one-clip hypertensive rats

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Abstract

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