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Article

Sphingosine kinase‑1 mediates endotoxemia‑induced hyperinflammation in aged animals

  • Authors:
    • Maria Lufrano
    • Asha Jacob
    • Mian Zhou
    • Ping Wang
  • View Affiliations / Copyright

    Affiliations: Laboratory of Surgical Research, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
  • Pages: 645-649
    |
    Published online on: June 28, 2013
       https://doi.org/10.3892/mmr.2013.1562
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Abstract

Sepsis is a serious issue in the geriatric population due to its association with high mortality rates in the elderly. The increase in mortality in the elderly correlates with inflammation. We have previously demonstrated that the inflammatory response is exacerbated in a rodent endotoxemia model of sepsis in aged rats compared with young rats. However, the molecular mediators associated with this hyperinflammatory response in aged rats have not been completely determined. Sphingosine kinase‑1 (Sphk‑1), an enzyme present in neutrophils and macrophages, regulates proinflammatory responses associated with endotoxemia and sepsis. To determine whether Sphk‑1 is a molecular mediator associated with the observed hyperinflammatory response in aging, Sphk‑1 mRNA expression was examined in hepatic tissues of young and aged rats subjected to endotoxemia. A significant increase in Sphk‑1 mRNA was observed in endotoxemic aged rats compared with young rats. This increase was correlated with a significant increase in TNF‑α mRNA levels in the liver. CD14 is a receptor component for lipopolysaccharide (LPS) and therefore, CD14 mRNA expression in hepatic tissues of endotoxemic young and aged rats was examined. Of note, CD14 mRNA was significantly upregulated in endotoxemic aged rats. Sphk‑1 mRNA expression was significantly elevated in LPS‑treated Kupffer cells and this increase correlated with an increase in CD14 mRNA expression. Results of the present study indicated that increased Sphk‑1 expression in the liver in response to endotoxemia mediates the hyperinflammatory state observed in aged animals.
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1 

Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J and Pinsky MR: Epidemiology of severe sepsis in the United States: analysis of incidence, outcome and associated costs of care. Crit Care Med. 29:1303–1310. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Martin GS, Mannino DM, Eaton S and Moss M: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 348:1546–1554. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Martin GS, Mannino DM and Moss M: The effect of age on the development and outcome of adult sepsis. Crit Care Med. 34:15–21. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Renshaw M, Rockwell J, Engleman C, Gewirtz A, Katz J and Sambhara S: Cutting edge: impaired Toll-like receptor expression and function in aging. J Immunol. 169:4697–4701. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Tateda K, Matsumoto T, Miyazaki S and Yamaguchi K: Lipopolysaccharide-induced lethality and cytokine production in aged mice. Infect Immun. 64:769–774. 1996.PubMed/NCBI

6 

Wu R, Zhou M, Dong W, et al: Ghrelin hyporesponsiveness contributes to age-related hyperinflammation in septic shock. Ann Surg. 250:126–133. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Zhou M, Wu R, Dong W, Leong J and Wang P: Accelerated apoptosis contributes to aging-related hyperinflammation in endotoxemia. Int J Mol Med. 25:929–935. 2010.PubMed/NCBI

8 

Spiegel S and Milstien S: Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol. 4:397–407. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Allende ML, Sasaki T, Kawai H, et al: Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. J Biol Chem. 279:52487–52492. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Egger M, Beer AG, Theurl M, et al: Monocyte migration: a novel effect and signaling pathways of catestatin. Eur J Pharmacol. 598:104–111. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Matloubian M, Lo CG, Cinamon G, et al: Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature. 427:355–360. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Xia P, Gamble JR, Rye KA, et al: Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway. Proc Natl Acad Sci USA. 95:14196–14201. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Billich A, Bornancin F, Mechtcheriakova D, Natt F, Huesken D and Baumruker T: Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators. Cell Signal. 17:1203–1217. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Alvarez SE, Milstien S and Spiegel S: Autocrine and paracrine roles of sphingosine-1-phosphate. Trends Endocrinol Metab. 18:300–307. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Melendez AJ: Sphingosine kinase signalling in immune cells: potential as novel therapeutic targets. Biochim Biophys Acta. 1784:66–75. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Puneet P, Yap CT, Wong L, et al: SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis. Science. 328:1290–1294. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Deguchi Y, Andoh A, Yagi Y, et al: The S1P receptor modulator FTY720 prevents the development of experimental colitis in mice. Oncol Rep. 16:699–703. 2006.PubMed/NCBI

18 

Kitano M, Hla T, Sekiguchi M, et al: Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. Arthritis Rheum. 54:742–753. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Lai WQ, Goh HH, Bao Z, Wong WS, Melendez AJ and Leung BP: The role of sphingosine kinase in a murine model of allergic asthma. J Immunol. 180:4323–4329. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Snider AJ, Kawamori T, Bradshaw SG, et al: A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis. Faseb J. 23:143–152. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Li Q, Wang C, Zhang Q, Tang C, Li N and Li J: The role of sphingosine kinase 1 in patients with severe acute pancreatitis. Ann Surg. 255:954–962. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Jacob A, Zhou M, Wu R, Halpern VJ, Ravikumar TS and Wang P: Pro-inflammatory cytokines from Kupffer cells downregulate hepatocyte expression of adrenomedullin binding protein-1. Biochim Biophys Acta. 1772:766–772. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Lu YC, Yeh WC and Ohashi PS: LPS/TLR4 signal transduction pathway. Cytokine. 42:145–151. 2008. View Article : Google Scholar

24 

Scott MJ, Liu S, Su GL, Vodovotz Y and Billiar TR: Hepatocytes enhance effects of lipopolysaccharide on liver nonparenchymal cells through close cell interactions. Shock. 23:453–458. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Weiskopf D, Weinberger B and Grubeck-Loebenstein B: The aging of the immune system. Transpl Int. 22:1041–1050. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Grolleau-Julius A, Ray D and Yung RL: The role of epigenetics in aging and autoimmunity. Clin Rev Allergy Immunol. 39:42–50. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Sawhney M, Mathew M, Valarmathi MT and Das SN: Age related changes in Fas (CD95) and Fas ligand gene expression and cytokine profiles in healthy Indians. Asian Pac J Allergy Immunol. 24:47–56. 2006.PubMed/NCBI

28 

Olivera A and Spiegel S: Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature. 365:557–560. 1993. View Article : Google Scholar : PubMed/NCBI

29 

Gluck T, Silver J, Epstein M, Cao P, Farber B and Goyert SM: Parameters influencing membrane CD14 expression and soluble CD14 levels in sepsis. Eur J Med Res. 6:351–358. 2001.PubMed/NCBI

30 

Pan Z, Zhou L, Hetherington CJ and Zhang DE: Hepatocytes contribute to soluble CD14 production and CD14 expression is differentially regulated in hepatocytes and monocytes. J Biol Chem. 275:36430–36435. 2000. View Article : Google Scholar : PubMed/NCBI

31 

Schutt C: Cd14. Int J Biochem Cell Biol. 31:545–549. 1999. View Article : Google Scholar

32 

LeVan TD, Bloom JW, Bailey TJ, et al: A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity. J Immunol. 167:5838–5844. 2001. View Article : Google Scholar

33 

Liu S, Shapiro RA, Nie S, Zhu D, Vodovotz Y and Billiar TR: Characterization of rat CD14 promoter and its regulation by transcription factors AP1 and Sp family proteins in hepatocytes. Gene. 250:137–147. 2000. View Article : Google Scholar : PubMed/NCBI

34 

Chou MH, Chuang JH, Eng HL, et al: Endotoxin and CD14 in the progression of biliary atresia. J Transl Med. 8:1382010. View Article : Google Scholar : PubMed/NCBI

35 

Chou MH, Chuang JH, Eng HL, et al: Effects of hepatocyte CD14 upregulation during cholestasis on endotoxin sensitivity. PLoS One. 7:e349032012. View Article : Google Scholar : PubMed/NCBI

36 

Sewnath ME, Levels HH, Oude Elferink R, et al: Endotoxin-induced mortality in bile duct-ligated rats after administration of reconstituted high-density lipoprotein. Hepatology. 32:1289–1299. 2000. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lufrano M, Jacob A, Zhou M and Wang P: Sphingosine kinase‑1 mediates endotoxemia‑induced hyperinflammation in aged animals. Mol Med Rep 8: 645-649, 2013.
APA
Lufrano, M., Jacob, A., Zhou, M., & Wang, P. (2013). Sphingosine kinase‑1 mediates endotoxemia‑induced hyperinflammation in aged animals. Molecular Medicine Reports, 8, 645-649. https://doi.org/10.3892/mmr.2013.1562
MLA
Lufrano, M., Jacob, A., Zhou, M., Wang, P."Sphingosine kinase‑1 mediates endotoxemia‑induced hyperinflammation in aged animals". Molecular Medicine Reports 8.2 (2013): 645-649.
Chicago
Lufrano, M., Jacob, A., Zhou, M., Wang, P."Sphingosine kinase‑1 mediates endotoxemia‑induced hyperinflammation in aged animals". Molecular Medicine Reports 8, no. 2 (2013): 645-649. https://doi.org/10.3892/mmr.2013.1562
Copy and paste a formatted citation
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Spandidos Publications style
Lufrano M, Jacob A, Zhou M and Wang P: Sphingosine kinase‑1 mediates endotoxemia‑induced hyperinflammation in aged animals. Mol Med Rep 8: 645-649, 2013.
APA
Lufrano, M., Jacob, A., Zhou, M., & Wang, P. (2013). Sphingosine kinase‑1 mediates endotoxemia‑induced hyperinflammation in aged animals. Molecular Medicine Reports, 8, 645-649. https://doi.org/10.3892/mmr.2013.1562
MLA
Lufrano, M., Jacob, A., Zhou, M., Wang, P."Sphingosine kinase‑1 mediates endotoxemia‑induced hyperinflammation in aged animals". Molecular Medicine Reports 8.2 (2013): 645-649.
Chicago
Lufrano, M., Jacob, A., Zhou, M., Wang, P."Sphingosine kinase‑1 mediates endotoxemia‑induced hyperinflammation in aged animals". Molecular Medicine Reports 8, no. 2 (2013): 645-649. https://doi.org/10.3892/mmr.2013.1562
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