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Article

Foreign body response induced by tissue expander implantation

  • Authors:
    • Lingling Sheng
    • Qingxiong Yu
    • Feng Xie
    • Qingfeng Li
  • View Affiliations / Copyright

    Affiliations: Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, P.R. China
  • Pages: 872-876
    |
    Published online on: December 27, 2013
       https://doi.org/10.3892/mmr.2013.1881
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Abstract

The foreign body response (FBR) is described as the host's response to implanted biomaterials, which involves a complex cascade of immune modulators. The dynamic changes of immune cells, inflammatory cytokines and the formation of a fibrous capsule remain to be elucidated. In the present study, a model of subcutaneous implantation of a tissue expander was used. The results revealed that macrophages, the main immune cells in FBR, infiltrated into the expanded tissue and located at the tissue‑material interface from day 1‑90. Following the decrease of the number of macrophages, collagen deposited and fibroblasts transformed into myofibroblasts at the tissue‑material interface, leading to the formation of a fibrous capsule from day 14. The persistent existing macrophages led to a high expression of proinflammatory cytokines, including tumor necrosis factor‑α and interleukin‑1β, both of which initiated the NK-κB and JNK inflammatory pathways, mediating the FBR to tissue expander implantation.
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Copy and paste a formatted citation
Spandidos Publications style
Sheng L, Yu Q, Xie F and Li Q: Foreign body response induced by tissue expander implantation. Mol Med Rep 9: 872-876, 2014.
APA
Sheng, L., Yu, Q., Xie, F., & Li, Q. (2014). Foreign body response induced by tissue expander implantation. Molecular Medicine Reports, 9, 872-876. https://doi.org/10.3892/mmr.2013.1881
MLA
Sheng, L., Yu, Q., Xie, F., Li, Q."Foreign body response induced by tissue expander implantation". Molecular Medicine Reports 9.3 (2014): 872-876.
Chicago
Sheng, L., Yu, Q., Xie, F., Li, Q."Foreign body response induced by tissue expander implantation". Molecular Medicine Reports 9, no. 3 (2014): 872-876. https://doi.org/10.3892/mmr.2013.1881
Copy and paste a formatted citation
x
Spandidos Publications style
Sheng L, Yu Q, Xie F and Li Q: Foreign body response induced by tissue expander implantation. Mol Med Rep 9: 872-876, 2014.
APA
Sheng, L., Yu, Q., Xie, F., & Li, Q. (2014). Foreign body response induced by tissue expander implantation. Molecular Medicine Reports, 9, 872-876. https://doi.org/10.3892/mmr.2013.1881
MLA
Sheng, L., Yu, Q., Xie, F., Li, Q."Foreign body response induced by tissue expander implantation". Molecular Medicine Reports 9.3 (2014): 872-876.
Chicago
Sheng, L., Yu, Q., Xie, F., Li, Q."Foreign body response induced by tissue expander implantation". Molecular Medicine Reports 9, no. 3 (2014): 872-876. https://doi.org/10.3892/mmr.2013.1881
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