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Article

Expression of PPAR-γ in adipose tissue of rats with polycystic ovary syndrome induced by DHEA

  • Authors:
    • Yu-Xia Wang
    • Wei-Jie Zhu
    • Bao-Guo Xie
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong 510630, P.R. China, Department of Developmental and Regenerative Biology, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, P.R. China
  • Pages: 889-893
    |
    Published online on: January 14, 2014
       https://doi.org/10.3892/mmr.2014.1895
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Abstract

The objective of this study was to investigate the expression of peroxisome proliferator-activated receptor-γ (PPAR-γ) in adipose tissue of the rat model of polycystic ovary syndrome (PCOS), induced by dehydroepiandrosterone (DHEA). Sixteen sexually immature Sprague-Dawley female rats were randomly assigned to the DHEA (n=8) or control (n=8) group. Adipose tissue was collected from the two rat groups following subcutaneous injection of DHEA in the DHEA group and a standard laboratory diet in the control group for 20 consecutive days. Reverse transcription polymerase chain reaction and western blot analysis were performed to detect expression of PPAR-γ at the mRNA and protein level in the adipose tissue. Both PPAR-γ mRNA and protein levels were decreased in the adipose tissue of DHEA‑induced PCOS rats compared to the control group. This decrease was significant (P<0.01). These results suggest that the pathogenesis of PCOS, which shares a number of common features with hyperandrogenemia, may involve the lipid metabolism pathway through inhibition of PPAR-γ.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Zhu W and Xie B: Expression of PPAR-γ in adipose tissue of rats with polycystic ovary syndrome induced by DHEA. Mol Med Rep 9: 889-893, 2014.
APA
Wang, Y., Zhu, W., & Xie, B. (2014). Expression of PPAR-γ in adipose tissue of rats with polycystic ovary syndrome induced by DHEA. Molecular Medicine Reports, 9, 889-893. https://doi.org/10.3892/mmr.2014.1895
MLA
Wang, Y., Zhu, W., Xie, B."Expression of PPAR-γ in adipose tissue of rats with polycystic ovary syndrome induced by DHEA". Molecular Medicine Reports 9.3 (2014): 889-893.
Chicago
Wang, Y., Zhu, W., Xie, B."Expression of PPAR-γ in adipose tissue of rats with polycystic ovary syndrome induced by DHEA". Molecular Medicine Reports 9, no. 3 (2014): 889-893. https://doi.org/10.3892/mmr.2014.1895
Copy and paste a formatted citation
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Spandidos Publications style
Wang Y, Zhu W and Xie B: Expression of PPAR-γ in adipose tissue of rats with polycystic ovary syndrome induced by DHEA. Mol Med Rep 9: 889-893, 2014.
APA
Wang, Y., Zhu, W., & Xie, B. (2014). Expression of PPAR-γ in adipose tissue of rats with polycystic ovary syndrome induced by DHEA. Molecular Medicine Reports, 9, 889-893. https://doi.org/10.3892/mmr.2014.1895
MLA
Wang, Y., Zhu, W., Xie, B."Expression of PPAR-γ in adipose tissue of rats with polycystic ovary syndrome induced by DHEA". Molecular Medicine Reports 9.3 (2014): 889-893.
Chicago
Wang, Y., Zhu, W., Xie, B."Expression of PPAR-γ in adipose tissue of rats with polycystic ovary syndrome induced by DHEA". Molecular Medicine Reports 9, no. 3 (2014): 889-893. https://doi.org/10.3892/mmr.2014.1895
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