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Review Open Access

DNA methylation profiles in ovarian cancer: Implication in diagnosis and therapy (Review)

  • Authors:
    • Ourania Koukoura
    • Demetrios A. Spandidos
    • Alexandros Daponte
    • Stavros Sifakis
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, University Hospital of Larissa, Larissa, Thessaly, Greece, Laboratory of Clinical Virology, University of Crete Medical School, Heraklion, Crete, Greece, Department of Obstetrics and Gynecology, University Hospital of Heraklion, Heraklion, Crete, Greece
    Copyright: © Koukoura et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 3-9
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    Published online on: May 8, 2014
       https://doi.org/10.3892/mmr.2014.2221
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Abstract

Genetic alterations alone cannot account for the complexity of ovarian cancer. The potential reversibility of epigenetic mechanisms makes them attractive candidates for the prevention and/or treatment of ovarian carcinoma. Detection of the epigenetic signature of each cancer cell may be useful in the identification of candidate biomarkers for disease detection, classification and monitoring and may also facilitate personalized cancer treatment. In ovarian cancer, in addition to other non‑gynaecological cancers, two opposite epigenetic phenomena occur. The first involves an overall global decrease in DNA methylation of heterochromatin leading to demethylation of several oncogenes, while the second involves specific CpG island hypermethylation associated with the promoters of tumor suppressor genes. Early studies focused on the methylation patterns of single genes associated with tumorigenesis. However, newer genome-wide methods have identified a group of genes whose regulation is altered by DNA methylation during ovarian cancer progression.
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Copy and paste a formatted citation
Spandidos Publications style
Koukoura O, Spandidos DA, Daponte A and Sifakis S: DNA methylation profiles in ovarian cancer: Implication in diagnosis and therapy (Review). Mol Med Rep 10: 3-9, 2014.
APA
Koukoura, O., Spandidos, D.A., Daponte, A., & Sifakis, S. (2014). DNA methylation profiles in ovarian cancer: Implication in diagnosis and therapy (Review). Molecular Medicine Reports, 10, 3-9. https://doi.org/10.3892/mmr.2014.2221
MLA
Koukoura, O., Spandidos, D. A., Daponte, A., Sifakis, S."DNA methylation profiles in ovarian cancer: Implication in diagnosis and therapy (Review)". Molecular Medicine Reports 10.1 (2014): 3-9.
Chicago
Koukoura, O., Spandidos, D. A., Daponte, A., Sifakis, S."DNA methylation profiles in ovarian cancer: Implication in diagnosis and therapy (Review)". Molecular Medicine Reports 10, no. 1 (2014): 3-9. https://doi.org/10.3892/mmr.2014.2221
Copy and paste a formatted citation
x
Spandidos Publications style
Koukoura O, Spandidos DA, Daponte A and Sifakis S: DNA methylation profiles in ovarian cancer: Implication in diagnosis and therapy (Review). Mol Med Rep 10: 3-9, 2014.
APA
Koukoura, O., Spandidos, D.A., Daponte, A., & Sifakis, S. (2014). DNA methylation profiles in ovarian cancer: Implication in diagnosis and therapy (Review). Molecular Medicine Reports, 10, 3-9. https://doi.org/10.3892/mmr.2014.2221
MLA
Koukoura, O., Spandidos, D. A., Daponte, A., Sifakis, S."DNA methylation profiles in ovarian cancer: Implication in diagnosis and therapy (Review)". Molecular Medicine Reports 10.1 (2014): 3-9.
Chicago
Koukoura, O., Spandidos, D. A., Daponte, A., Sifakis, S."DNA methylation profiles in ovarian cancer: Implication in diagnosis and therapy (Review)". Molecular Medicine Reports 10, no. 1 (2014): 3-9. https://doi.org/10.3892/mmr.2014.2221
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