Differential expression of stromal aromatase in obese females is regulated by DNA methylation

Zeng,Xian‑Cheng; Ao,Xiang; Yang,Hai‑Feng; Zhang,Guang‑Xian; Li,Wen‑Hong; Liu,Qi‑Long; Tang,Yue‑Liang; Xie,Yi‑Cheng; He,Wen‑Guang; Huang,Yan‑Nian; Zhang,Lei; Li,Rong‑Jiang

doi:10.3892/mmr.2014.2275

August-2014 Volume 10 Issue 2

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August-2014 Volume 10 Issue 2

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Article

Differential expression of stromal aromatase in obese females is regulated by DNA methylation

Authors:
- Xian‑Cheng Zeng
- Xiang Ao
- Hai‑Feng Yang
- Guang‑Xian Zhang
- Wen‑Hong Li
- Qi‑Long Liu
- Yue‑Liang Tang
- Yi‑Cheng Xie
- Wen‑Guang He
- Yan‑Nian Huang
- Lei Zhang
- Rong‑Jiang Li
View Affiliations / Copyright

Affiliations: Department of General Surgery, Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-Sen University), Zengcheng 511300, P.R. China, Department of Breast Surgery, The Affiliated Cancer Hospital of Guangzhou Medical University, Guangzhou 510095, P.R. China, Department of Pathology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of TCM), Guangzhou 510120, P.R. China, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, P.R. China, Department of Clinical Laboratory, Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-Sen University), Zengcheng 511300, P.R. China, Department of General Surgery, Affiliated Xixiang People's Hospital of Guangdong Medical College, Shenzhen 518102, P.R. China
Pages: 887-890
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Published online on: May 27, 2014

https://doi.org/10.3892/mmr.2014.2275
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Abstract

Obesity increases the incidence, progression and mortality of breast cancer among postmenopausal females. This is partly due to excessive estrogen production in the adipose tissue of obese females. Aromatase is a key enzyme in estrogen biosynthesis. In the current study, the tensional force‑triggered inducibility of aromatase expression was observed to vary in ASCs isolated from different disease‑free individuals. In addition, this phenomenon was associated with the activation of the aromatase PII promoter and its DNA methylation load. These findings highlight the impact of tensional forces on estrogen biosynthesis in obese females.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Differential expression of stromal aromatase in obese females is regulated by DNA methylation

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Abstract

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