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Article

Protein phosphatase 4 promotes hepatic lipogenesis through dephosphorylating acetyl‑CoA carboxylase 1 on serine 79

  • Authors:
    • Xiangyu Meng
    • Meng Li
    • Jun Guo
    • Weiqing Tang
    • Shu  Wang
    • Yong Man
    • Xiuqing Huang
    • Jian Li
  • View Affiliations / Copyright

    Affiliations: Peking University Fifth School of Clinical Medicine, Beijing Hospital, Ministry of Health, Beijing 100730, P.R. China, The Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing 100730, P.R. China
  • Pages: 1959-1963
    |
    Published online on: July 18, 2014
       https://doi.org/10.3892/mmr.2014.2397
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Abstract

Reversible phosphorylation has a critical role in the regulation of the activity of acetyl‑CoA carboxylase 1 (ACC1), which is associated with de novo lipogenesis. It has been shown that AMP‑activated protein kinase (AMPK) phosphorylates ACC1 on serine 79 and inhibits its activity; however, the mechanism of ACC1 dephosphorylation remains elusive. Protein phosphatase 4 (PP4), a ubiquitous serine/threonine phosphatase, regulates a variety of cellular functions; however, whether PP4 is involved in lipid metabolism has yet to be elucidated. In the present study, PP4 was identified as a novel regulator of ACC1, which is also involved in hepatic lipogenesis. The expression of PP4 was found to be significantly increased in the livers of db/db mice. Furthermore, pACC1‑Ser79/ACC1 levels were observed to be decreased and high triglyceride accumulation was found in the livers of db/db mice. Moreover, PP4 overexpression was observed to lead to a decreased pACC1‑Ser79/ACC1 ratio and subsequently an increased intracellular triglyceride content in mouse primary hepatocytes. PP4 was also found to directly interact with pACC1‑Ser79 in human HepG2 cells. In conclusion, the present study showed that PP4 may be a novel regulator in hepatic lipogenesis through dephosphorylating ACC1 on serine 79, suggesting that PP4 may be a promising therapeutic target in lipid metabolism disorders.
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Copy and paste a formatted citation
Spandidos Publications style
Meng X, Li M, Guo J, Tang W, Wang S, Man Y, Huang X and Li J: Protein phosphatase 4 promotes hepatic lipogenesis through dephosphorylating acetyl‑CoA carboxylase 1 on serine 79. Mol Med Rep 10: 1959-1963, 2014.
APA
Meng, X., Li, M., Guo, J., Tang, W., Wang, S., Man, Y. ... Li, J. (2014). Protein phosphatase 4 promotes hepatic lipogenesis through dephosphorylating acetyl‑CoA carboxylase 1 on serine 79. Molecular Medicine Reports, 10, 1959-1963. https://doi.org/10.3892/mmr.2014.2397
MLA
Meng, X., Li, M., Guo, J., Tang, W., Wang, S., Man, Y., Huang, X., Li, J."Protein phosphatase 4 promotes hepatic lipogenesis through dephosphorylating acetyl‑CoA carboxylase 1 on serine 79". Molecular Medicine Reports 10.4 (2014): 1959-1963.
Chicago
Meng, X., Li, M., Guo, J., Tang, W., Wang, S., Man, Y., Huang, X., Li, J."Protein phosphatase 4 promotes hepatic lipogenesis through dephosphorylating acetyl‑CoA carboxylase 1 on serine 79". Molecular Medicine Reports 10, no. 4 (2014): 1959-1963. https://doi.org/10.3892/mmr.2014.2397
Copy and paste a formatted citation
x
Spandidos Publications style
Meng X, Li M, Guo J, Tang W, Wang S, Man Y, Huang X and Li J: Protein phosphatase 4 promotes hepatic lipogenesis through dephosphorylating acetyl‑CoA carboxylase 1 on serine 79. Mol Med Rep 10: 1959-1963, 2014.
APA
Meng, X., Li, M., Guo, J., Tang, W., Wang, S., Man, Y. ... Li, J. (2014). Protein phosphatase 4 promotes hepatic lipogenesis through dephosphorylating acetyl‑CoA carboxylase 1 on serine 79. Molecular Medicine Reports, 10, 1959-1963. https://doi.org/10.3892/mmr.2014.2397
MLA
Meng, X., Li, M., Guo, J., Tang, W., Wang, S., Man, Y., Huang, X., Li, J."Protein phosphatase 4 promotes hepatic lipogenesis through dephosphorylating acetyl‑CoA carboxylase 1 on serine 79". Molecular Medicine Reports 10.4 (2014): 1959-1963.
Chicago
Meng, X., Li, M., Guo, J., Tang, W., Wang, S., Man, Y., Huang, X., Li, J."Protein phosphatase 4 promotes hepatic lipogenesis through dephosphorylating acetyl‑CoA carboxylase 1 on serine 79". Molecular Medicine Reports 10, no. 4 (2014): 1959-1963. https://doi.org/10.3892/mmr.2014.2397
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