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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October 2014 Volume 10 Issue 4

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Article

Survivin depletion inhibits tumor growth and enhances chemosensitivity in hepatocellular carcinoma

  • Authors:
    • Yvonne Y.Y. Or
    • Ariel K.M. Chow
    • Lui Ng
    • Sheung Tat Fan
    • Thomas  C.C. Yau
    • Ronnie T.P. Poon
    • Roberta W.C. Pang
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, P.R. China
  • Pages: 2025-2030
    |
    Published online on: July 22, 2014
       https://doi.org/10.3892/mmr.2014.2413
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Abstract

Survivin is a member of the inhibitor of apoptosis family, which has been suggested to be crucial in the control of cell division and inhibition of apoptosis. Expression of this protein has been observed in transformed cell lines and human tumor tissues, including those from colorectal cancer, but not in terminally differentiated adult tissues. Survivin mRNA expression has frequently been detected in hepatocellular carcinoma (HCC) and its protein expression has been demonstrated to be highly correlated with proliferation index rather than apoptotic index. The present study aimed to analyze the effect of survivin on the tumorigenicity and chemosensitivity of HCC via the establishment of an HCC cell line (PLC/PRF/5) with the stable knockdown of the survivin gene (PLC‑k3). This cell line displayed significantly lower rates of survival and proliferation in assays of cell viability and proliferation, respectively, compared with those of the control cell line (PLC‑v). In addition, PLC‑k3 cells were more sensitive to cisplatin treatment, resulting in S phase arrest. These findings were further confirmed by an in vivo experiment. The data of the present study suggest that survivin is critical in promoting cell proliferation but not in inhibition of apoptosis, and enhances the chemosensitivity of HCC. Thus, the suppression of survivin expression in combination with cisplatin may contribute to the development of more effective treatments for HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Or YY, Chow AK, Ng L, Fan ST, Yau TC, Poon RT and Pang RW: Survivin depletion inhibits tumor growth and enhances chemosensitivity in hepatocellular carcinoma. Mol Med Rep 10: 2025-2030, 2014.
APA
Or, Y.Y., Chow, A.K., Ng, L., Fan, S.T., Yau, T.C., Poon, R.T., & Pang, R.W. (2014). Survivin depletion inhibits tumor growth and enhances chemosensitivity in hepatocellular carcinoma. Molecular Medicine Reports, 10, 2025-2030. https://doi.org/10.3892/mmr.2014.2413
MLA
Or, Y. Y., Chow, A. K., Ng, L., Fan, S. T., Yau, T. C., Poon, R. T., Pang, R. W."Survivin depletion inhibits tumor growth and enhances chemosensitivity in hepatocellular carcinoma". Molecular Medicine Reports 10.4 (2014): 2025-2030.
Chicago
Or, Y. Y., Chow, A. K., Ng, L., Fan, S. T., Yau, T. C., Poon, R. T., Pang, R. W."Survivin depletion inhibits tumor growth and enhances chemosensitivity in hepatocellular carcinoma". Molecular Medicine Reports 10, no. 4 (2014): 2025-2030. https://doi.org/10.3892/mmr.2014.2413
Copy and paste a formatted citation
x
Spandidos Publications style
Or YY, Chow AK, Ng L, Fan ST, Yau TC, Poon RT and Pang RW: Survivin depletion inhibits tumor growth and enhances chemosensitivity in hepatocellular carcinoma. Mol Med Rep 10: 2025-2030, 2014.
APA
Or, Y.Y., Chow, A.K., Ng, L., Fan, S.T., Yau, T.C., Poon, R.T., & Pang, R.W. (2014). Survivin depletion inhibits tumor growth and enhances chemosensitivity in hepatocellular carcinoma. Molecular Medicine Reports, 10, 2025-2030. https://doi.org/10.3892/mmr.2014.2413
MLA
Or, Y. Y., Chow, A. K., Ng, L., Fan, S. T., Yau, T. C., Poon, R. T., Pang, R. W."Survivin depletion inhibits tumor growth and enhances chemosensitivity in hepatocellular carcinoma". Molecular Medicine Reports 10.4 (2014): 2025-2030.
Chicago
Or, Y. Y., Chow, A. K., Ng, L., Fan, S. T., Yau, T. C., Poon, R. T., Pang, R. W."Survivin depletion inhibits tumor growth and enhances chemosensitivity in hepatocellular carcinoma". Molecular Medicine Reports 10, no. 4 (2014): 2025-2030. https://doi.org/10.3892/mmr.2014.2413
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