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Article

Dyclonine enhances the cytotoxic effect of proteasome inhibitor bortezomib in multiple myeloma cells

  • Authors:
    • Donghong Ju
    • Youming Xie
  • View Affiliations / Copyright

    Affiliations: Karmanos Cancer Institute, Department of Oncology and Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
  • Pages: 2609-2612
    |
    Published online on: August 28, 2014
       https://doi.org/10.3892/mmr.2014.2522
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Abstract

The proteasome has become an important target for cancer therapy with the approval of bortezomib for the treatment of relapsed/refractory multiple myeloma (MM). However, numerous patients with MM do not respond to bortezomib and those responding initially often acquire resistance. Recent clinical studies have also demonstrated that bortezomib is also inefficacious in the treatment of other types of cancer. Therefore, it is imperative to develop novel approaches and agents for proteasome-targeting cancer therapy. In the present study, it was revealed that dyclonine, a major component of the cough droplets Sucrets, markedly enhances the cytotoxic effects of bortezomib and minimizes drug resistance in MM cells. It was demonstrated that a combination of bortezomib and dyclonine markedly induced apoptosis of MM cells. The present study suggests a novel therapeutic use of an over‑the‑counter medicine for the treatment of MM.
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Copy and paste a formatted citation
Spandidos Publications style
Ju D and Xie Y: Dyclonine enhances the cytotoxic effect of proteasome inhibitor bortezomib in multiple myeloma cells. Mol Med Rep 10: 2609-2612, 2014.
APA
Ju, D., & Xie, Y. (2014). Dyclonine enhances the cytotoxic effect of proteasome inhibitor bortezomib in multiple myeloma cells. Molecular Medicine Reports, 10, 2609-2612. https://doi.org/10.3892/mmr.2014.2522
MLA
Ju, D., Xie, Y."Dyclonine enhances the cytotoxic effect of proteasome inhibitor bortezomib in multiple myeloma cells". Molecular Medicine Reports 10.5 (2014): 2609-2612.
Chicago
Ju, D., Xie, Y."Dyclonine enhances the cytotoxic effect of proteasome inhibitor bortezomib in multiple myeloma cells". Molecular Medicine Reports 10, no. 5 (2014): 2609-2612. https://doi.org/10.3892/mmr.2014.2522
Copy and paste a formatted citation
x
Spandidos Publications style
Ju D and Xie Y: Dyclonine enhances the cytotoxic effect of proteasome inhibitor bortezomib in multiple myeloma cells. Mol Med Rep 10: 2609-2612, 2014.
APA
Ju, D., & Xie, Y. (2014). Dyclonine enhances the cytotoxic effect of proteasome inhibitor bortezomib in multiple myeloma cells. Molecular Medicine Reports, 10, 2609-2612. https://doi.org/10.3892/mmr.2014.2522
MLA
Ju, D., Xie, Y."Dyclonine enhances the cytotoxic effect of proteasome inhibitor bortezomib in multiple myeloma cells". Molecular Medicine Reports 10.5 (2014): 2609-2612.
Chicago
Ju, D., Xie, Y."Dyclonine enhances the cytotoxic effect of proteasome inhibitor bortezomib in multiple myeloma cells". Molecular Medicine Reports 10, no. 5 (2014): 2609-2612. https://doi.org/10.3892/mmr.2014.2522
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