Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
November-2014 Volume 10 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2014 Volume 10 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

ER stress in adipocytes and insulin resistance: Mechanisms and significance (Review)

  • Authors:
    • Shahzad Khan
    • Chang Hua Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pathophysiology, Wuhan University School of Medicine, Wuhan, Hubei 430071, P.R. China
  • Pages: 2234-2240
    |
    Published online on: September 3, 2014
       https://doi.org/10.3892/mmr.2014.2532
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Adipose tissue (AT) has numerous important functions within the body. Of particular importance is its role as an endocrine organ in the control of whole‑body glucose and lipid metabolism, which is achieved by the secretion of various proteins. Among these proteins are adipokines, such as adiponectin, leptin, resistin, interleukin‑6 and tumor necrosis factor‑α. An imbalance in the expression of these adipokines occurs in a variety of conditions, such as obesity, and can lead to various metabolic abnormalities, including hyperglycemia and hyperlipidemia. In turn, this can contribute to insulin resistance (IR) and heart diseases. Adipose endoplasmic reticulum (ER) stress is increasingly recognized as the primary factor governing these conditions, which ultimately result in the initiation of IR or the aggravation of pre‑existing IR. Studies have suggested that a number of conditions, including obesity, nutrient overload and metabolic syndromes, can initiate or enhance this process in a multi‑dimensional manner. This review focuses on the mechanism by which ER stress in AT can contribute to IR.
View Figures

Figure 1

View References

1 

Schröder M: Endoplasmic reticulum stress responses. Cell Mol Life Sci. 65:862–894. 2008.

2 

Winnay JN and Kahn CR: PI 3-kinase regulatory subunits as regulators of the unfolded protein response. Methods Enzymol. 490:147–158. 2011. View Article : Google Scholar : PubMed/NCBI

3 

van der Kallen CJ, van Greevenbroek MM, Stehouwer CD and Schalkwijk CG: Endoplasmic reticulum stress-induced apoptosis in the development of diabetes: is there a role for adipose tissue and liver? Apoptosis. 14:1424–1434. 2009.

4 

Schröder M and Kaufman RJ: The mammalian unfolded protein response. Annu Rev Biochem. 74:739–789. 2005.

5 

Hollien J and Weissman JS: Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science. 313:104–107. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Hu P, Han Z, Couvillon AD, Kaufman RJ and Exton JH: Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Mol Cell Biol. 26:3071–3084. 2006. View Article : Google Scholar

7 

Urano F, Wang X, Bertolotti A, et al: Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science. 287:664–666. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Deng J, Lu PD, Zhang Y, et al: Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol. 24:10161–10168. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Jiang HY, Wek SA, McGrath BC, et al: Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses. Mol Cell Biol. 23:5651–5663. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Wu S, Tan M, Hu Y, Wang JL, Scheuner D and Kaufman RJ: Ultraviolet light activates NFkappaB through translational inhibition of IkappaBalpha synthesis. J Biol Chem. 279:34898–34902. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Yamazaki H, Hiramatsu N, Hayakawa K, et al: Activation of the Akt-NF-kappaB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response. J Immunol. 183:1480–1487. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Zhang K, Shen X, Wu J, et al: Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell. 124:587–599. 2006. View Article : Google Scholar

13 

Ozcan U, Cao Q, Yilmaz E, et al: Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science. 306:457–461. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Mondal AK, Das SK, Varma V, et al: Effect of endoplasmic reticulum stress on inflammation and adiponectin regulation in human adipocytes. Metab Syndr Relat Disord. 10:297–306. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Wu J and Kaufman RJ: From acute ER stress to physiological roles of the Unfolded Protein Response. Cell Death Differ. 13:374–384. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Boden G, Duan X, Homko C, et al: Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Diabetes. 57:2438–2444. 2008. View Article : Google Scholar

17 

Sharma NK, Das SK, Mondal AK, et al: Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects. J Clin Endocrinol Metab. 93:4532–4541. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Gregor MF, Yang L, Fabbrini E, et al: Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes. 58:693–700. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Fleischmann E, Kurz A, Niedermayr M, et al: Tissue oxygenation in obese and non-obese patients during laparoscopy. Obes Surg. 15:813–819. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Virtanen KA, Lönnroth P, Parkkola R, et al: Glucose uptake and perfusion in subcutaneous and visceral adipose tissue during insulin stimulation in nonobese and obese humans. J Clin Endocrinol Metab. 87:3902–3910. 2002. View Article : Google Scholar

21 

Furukawa S, Fujita T, Shimabukuro M, et al: Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 114:1752–1761. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Hosogai N, Fukuhara A, Oshima K, et al: Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes. 56:901–911. 2007. View Article : Google Scholar

23 

Lazar MA: How obesity causes diabetes: not a tall tale. Science. 307:373–375. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Heilbronn LK and Campbell LV: Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity. Curr Pharm Des. 14:1225–1230. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Lewis JS, Lee JA, Underwood JC, Harris AL and Lewis CE: Macrophage responses to hypoxia: relevance to disease mechanisms. J Leukoc Biol. 66:889–900. 1999.PubMed/NCBI

26 

Spiegelman BM: PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. Diabetes. 47:507–514. 1998. View Article : Google Scholar : PubMed/NCBI

27 

Yin J, Gao Z, He Q, Zhou D, Guo Z and Ye J: Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue. Am J Physiol Endocrinol Metab. 296:E333–E342. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Samuel VT and Shulman GI: Mechanisms for insulin resistance: common threads and missing links. Cell. 148:852–871. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Zeyda M and Stulnig TM: Obesity, inflammation, and insulin resistance - a mini-review. Gerontology. 55:379–386. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Kars M, Yang L, Gregor MF, et al: Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes. 59:1899–1905. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Nakatani Y, Kaneto H, Kawamori D, et al: Involvement of endoplasmic reticulum stress in insulin resistance and diabetes. J Biol Chem. 280:847–851. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Ozcan U, Yilmaz E, Ozcan L, et al: Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science. 313:1137–1140. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Kim DS, Jeong SK, Kim HR, Kim DS, Chae SW and Chae HJ: Effects of triglyceride on ER stress and insulin resistance. Biochem Biophys Res Commun. 363:140–145. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Gual P, Le Marchand-Brustel Y and Tanti JF: Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie. 87:99–109. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Yuan M, Konstantopoulos N, Lee J, et al: Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science. 293:1673–1677. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Itani SI, Ruderman NB, Schmieder F and Boden G: Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes. 51:2005–2011. 2002. View Article : Google Scholar : PubMed/NCBI

37 

Arkan MC, Hevener AL, Greten FR, et al: IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med. 11:191–198. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Hirosumi J, Tuncman G, Chang L, et al: A central role for JNK in obesity and insulin resistance. Nature. 420:333–336. 2002. View Article : Google Scholar : PubMed/NCBI

39 

Zhang K and Kaufman RJ: From endoplasmic-reticulum stress to the inflammatory response. Nature. 454:455–462. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Nakamura T, Furuhashi M, Li P, et al: Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell. 140:338–348. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Kyriakis JM and Avruch J: Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev. 81:807–869. 2001.PubMed/NCBI

42 

Shoelson SE, Lee J and Goldfine AB: Inflammation and insulin resistance. J Clin Invest. 116:1793–1801. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Boden G and Merali S: Measurement of the increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Methods Enzymol. 489:67–82. 2011. View Article : Google Scholar

44 

Xu L, Spinas GA and Niessen M: ER stress in adipocytes inhibits insulin signaling, represses lipolysis, and alters the secretion of adipokines without inhibiting glucose transport. Horm Metab Res. 42:643–651. 2010. View Article : Google Scholar

45 

Liu M, Zhou L, Xu A, et al: A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization. Proc Natl Acad Sci USA. 105:18302–18307. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Zhou L, Liu M, Zhang J, Chen H, Dong LQ and Liu F: DsbA-L alleviates endoplasmic reticulum stress-induced adiponectin downregulation. Diabetes. 59:2809–2816. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Lefterova MI, Mullican SE, Tomaru T, Qatanani M, Schupp M and Lazar MA: Endoplasmic reticulum stress regulates adipocyte resistin expression. Diabetes. 58:1879–1886. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Hu E, Liang P and Spiegelman BM: AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem. 271:10697–10703. 1996. View Article : Google Scholar : PubMed/NCBI

49 

Berg AH, Combs TP and Scherer PE: ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab. 13:84–89. 2002. View Article : Google Scholar : PubMed/NCBI

50 

Menzaghi C, Ercolino T, Di Paola R, et al: A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. Diabetes. 51:2306–2312. 2002. View Article : Google Scholar

51 

Kern PA, Di Gregorio GB, Lu T, Rassouli N and Ranganathan G: Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression. Diabetes. 52:1779–1785. 2003. View Article : Google Scholar

52 

Lara-Castro C, Luo N, Wallace P, Klein RL and Garvey WT: Adiponectin multimeric complexes and the metabolic syndrome trait cluster. Diabetes. 55:249–259. 2006. View Article : Google Scholar : PubMed/NCBI

53 

Kaser S, Kaser A, Sandhofer A, Ebenbichler CF, Tilg H and Patsch JR: Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro. Biochem Biophys Res Commun. 309:286–290. 2003. View Article : Google Scholar : PubMed/NCBI

54 

Silha JV, Krsek M, Skrha JV, Sucharda P, Nyomba BL and Murphy LJ: Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance. Eur J Endocrinol. 149:331–335. 2003. View Article : Google Scholar

55 

Vozarova de Courten B, Degawa-Yamauchi M, Considine RV and Tataranni PA: High serum resistin is associated with an increase in adiposity but not a worsening of insulin resistance in Pima Indians. Diabetes. 53:1279–1284. 2004.PubMed/NCBI

56 

Lee JH, Chan JL, Yiannakouris N, et al: Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects. J Clin Endocrinol Metab. 88:4848–4856. 2003. View Article : Google Scholar

57 

Gherlan I, Vladoiu S, Alexiu F, et al: Adipocytokine profile and insulin resistance in childhood obesity. Maedica (Buchar). 7:205–213. 2012.PubMed/NCBI

58 

Hotamisligil GS: Inflammation and metabolic disorders. Nature. 444:860–867. 2006. View Article : Google Scholar : PubMed/NCBI

59 

Friedman JM and Halaas JL: Leptin and the regulation of body weight in mammals. Nature. 395:763–770. 1998. View Article : Google Scholar : PubMed/NCBI

60 

Kiefer FW, Zeyda M, Todoric J, et al: Osteopontin expression in human and murine obesity: extensive local up-regulation in adipose tissue but minimal systemic alterations. Endocrinology. 149:1350–1357. 2008. View Article : Google Scholar

61 

Kahn BB and Flier JS: Obesity and insulin resistance. J Clin Invest. 106:473–481. 2000. View Article : Google Scholar : PubMed/NCBI

62 

Jiao P, Ma J, Feng B, et al: FFA-induced adipocyte inflammation and insulin resistance: involvement of ER stress and IKKβ pathways. Obesity (Silver Spring). 19:483–491. 2011.PubMed/NCBI

63 

Bruun JM, Verdich C, Toubro S, Astrup A and Richelsen B: Association between measures of insulin sensitivity and circulating levels of interleukin-8, interleukin-6 and tumor necrosis factor-alpha. Effect of weight loss in obese men. Eur J Endocrinol. 148:535–542. 2003. View Article : Google Scholar

64 

Sung HY, Hong CG, Suh YS, et al: Role of (−)-epigallocatechin-3-gallate in cell viability, lipogenesis, and retinol-binding protein 4 expression in adipocytes. Naunyn Schmiedebergs Arch Pharmacol. 382:303–310. 2010.

65 

Meng L, Zhou J, Sasano H, Suzuki T, Zeitoun KM and Bulun SE: Tumor necrosis factor alpha and interleukin 11 secreted by malignant breast epithelial cells inhibit adipocyte differentiation by selectively down-regulating CCAAT/enhancer binding protein alpha and peroxisome proliferator-activated receptor gamma: mechanism of desmoplastic reaction. Cancer Res. 61:2250–2255. 2001.

66 

Ruan H, Pownall HJ and Lodish HF: Troglitazone antagonizes tumor necrosis factor-alpha-induced reprogramming of adipocyte gene expression by inhibiting the transcriptional regulatory functions of NF-kappaB. J Biol Chem. 278:28181–28192. 2003. View Article : Google Scholar

67 

Ritchie SA, Ewart MA, Perry CG, Connell JM and Salt IP: The role of insulin and the adipocytokines in regulation of vascular endothelial function. Clin Sci (Lond). 107:519–532. 2004. View Article : Google Scholar : PubMed/NCBI

68 

Hotamisligil GS, Shargill NS and Spiegelman BM: Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 259:87–91. 1993. View Article : Google Scholar : PubMed/NCBI

69 

Uysal KT, Wiesbrock SM, Marino MW and Hotamisligil GS: Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature. 389:610–614. 1997. View Article : Google Scholar : PubMed/NCBI

70 

Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF and Spiegelman BM: IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science. 271:665–668. 1996. View Article : Google Scholar

71 

Shi H, Tzameli I, Bjørbaek C and Flier JS: Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling. J Biol Chem. 279:34733–34740. 2004. View Article : Google Scholar : PubMed/NCBI

72 

Jager J, Grémeaux T, Cormont M, Le Marchand-Brustel Y and Tanti JF: Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology. 148:241–251. 2007. View Article : Google Scholar : PubMed/NCBI

73 

Griendling KK, Sorescu D and Ushio-Fukai M: NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res. 86:494–501. 2000. View Article : Google Scholar : PubMed/NCBI

74 

Xue X, Piao JH, Nakajima A, et al: Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha. J Biol Chem. 280:33917–33925. 2005. View Article : Google Scholar

75 

Li WW, Alexandre S, Cao X and Lee AS: Transactivation of the grp78 promoter by Ca2+ depletion. A comparative analysis with A23187 and the endoplasmic reticulum Ca(2+)-ATPase inhibitor thapsigargin. J Biol Chem. 268:12003–12009. 1993.PubMed/NCBI

76 

Tsujino M, Hirata Y, Imai T, et al: Induction of nitric oxide synthase gene by interleukin-1 beta in cultured rat cardiocytes. Circulation. 90:375–383. 1994. View Article : Google Scholar : PubMed/NCBI

77 

Cole BK, Kuhn NS, Green-Mitchell SM, et al: 12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response. Am J Physiol Endocrinol Metab. 302:E654–E665. 2012. View Article : Google Scholar : PubMed/NCBI

78 

Zhou L and Liu F: Autophagy: roles in obesity-induced ER stress and adiponectin downregulation in adipocytes. Autophagy. 6:1196–1197. 2010. View Article : Google Scholar : PubMed/NCBI

79 

Pfaffenbach KT, Gentile CL, Nivala AM, Wang D, Wei Y and Pagliassotti MJ: Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death. Am J Physiol Endocrinol Metab. 298:E1027–E1035. 2010. View Article : Google Scholar

80 

Zhou QG, Zhou M, Hou FF and Peng X: Asymmetrical dimethylarginine triggers lipolysis and inflammatory response via induction of endoplasmic reticulum stress in cultured adipocytes. Am J Physiol Endocrinol Metab. 296:E869–E878. 2009. View Article : Google Scholar

81 

Deng J, Liu S, Zou L, Xu C, Geng B and Xu G: Lipolysis response to endoplasmic reticulum stress in adipose cells. J Biol Chem. 287:6240–6249. 2012. View Article : Google Scholar : PubMed/NCBI

82 

Cnop M, Foufelle F and Velloso LA: Endoplasmic reticulum stress, obesity and diabetes. Trends Mol Med. 18:59–68. 2012. View Article : Google Scholar : PubMed/NCBI

83 

Boden G, Lebed B, Schatz M, Homko C and Lemieux S: Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects. Diabetes. 50:1612–1617. 2001. View Article : Google Scholar : PubMed/NCBI

84 

Reaven GM, Hollenbeck C, Jeng CY, Wu MS and Chen YD: Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM. Diabetes. 37:1020–1024. 1988. View Article : Google Scholar : PubMed/NCBI

85 

Nguyen MT, Satoh H, Favelyukis S, et al: JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J Biol Chem. 280:35361–35371. 2005. View Article : Google Scholar : PubMed/NCBI

86 

Gao Z, Hwang D, Bataille F, et al: Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. J Biol Chem. 277:48115–48121. 2002. View Article : Google Scholar : PubMed/NCBI

87 

Haukeland JW, Dahl TB, Yndestad A, et al: Fetuin A in nonalcoholic fatty liver disease: in vivo and in vitro studies. Eur J Endocrinol. 166:503–510. 2012. View Article : Google Scholar : PubMed/NCBI

88 

Arner P: Insulin resistance in type 2 diabetes: role of fatty acids. Diabetes Metab Res Rev. 18(Suppl 2): S5–S9. 2002. View Article : Google Scholar : PubMed/NCBI

89 

Jensen MD: Adipose tissue metabolism - an aspect we should not neglect? Horm Metab Res. 39:722–725. 2007. View Article : Google Scholar

90 

Gregor MF and Hotamisligil GS: Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease. J Lipid Res. 48:1905–1914. 2007. View Article : Google Scholar

91 

Bollheimer LC, Skelly RH, Chester MW, McGarry JD and Rhodes CJ: Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation. J Clin Invest. 101:1094–1101. 1998. View Article : Google Scholar

92 

Liu YQ, Jetton TL and Leahy JL: beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats. J Biol Chem. 277:39163–39168. 2002. View Article : Google Scholar

93 

Prentki M and Nolan CJ: Islet beta cell failure in type 2 diabetes. J Clin Invest. 116:1802–1812. 2006. View Article : Google Scholar : PubMed/NCBI

94 

McGarry JD and Dobbins RL: Fatty acids, lipotoxicity and insulin secretion. Diabetologia. 42:128–138. 1999. View Article : Google Scholar : PubMed/NCBI

95 

Kharroubi I, Ladrière L, Cardozo AK, Dogusan Z, Cnop M and Eizirik DL: Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress. Endocrinology. 145:5087–5096. 2004. View Article : Google Scholar

96 

Cunha DA, Hekerman P, Ladrière L, et al: Initiation and execution of lipotoxic ER stress in pancreatic beta-cells. J Cell Sci. 121:2308–2318. 2008. View Article : Google Scholar : PubMed/NCBI

97 

Ryden M, Dicker A, van Harmelen V, et al: Mapping of early signaling events in tumor necrosis factor-alpha -mediated lipolysis in human fat cells. J Biol Chem. 277:1085–1091. 2002. View Article : Google Scholar : PubMed/NCBI

98 

Fricke K, Heitland A and Maronde E: Cooperative activation of lipolysis by protein kinase A and protein kinase C pathways in 3T3-L1 adipocytes. Endocrinology. 145:4940–4947. 2004. View Article : Google Scholar : PubMed/NCBI

99 

Kawasaki N, Asada R, Saito A, Kanemoto S and Imaizumi K: Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue. Sci Rep. 2:7992012. View Article : Google Scholar : PubMed/NCBI

100 

Malhotra JD and Kaufman RJ: Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid Redox Signal. 9:2277–2293. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Khan S and Wang CH: ER stress in adipocytes and insulin resistance: Mechanisms and significance (Review). Mol Med Rep 10: 2234-2240, 2014.
APA
Khan, S., & Wang, C.H. (2014). ER stress in adipocytes and insulin resistance: Mechanisms and significance (Review). Molecular Medicine Reports, 10, 2234-2240. https://doi.org/10.3892/mmr.2014.2532
MLA
Khan, S., Wang, C. H."ER stress in adipocytes and insulin resistance: Mechanisms and significance (Review)". Molecular Medicine Reports 10.5 (2014): 2234-2240.
Chicago
Khan, S., Wang, C. H."ER stress in adipocytes and insulin resistance: Mechanisms and significance (Review)". Molecular Medicine Reports 10, no. 5 (2014): 2234-2240. https://doi.org/10.3892/mmr.2014.2532
Copy and paste a formatted citation
x
Spandidos Publications style
Khan S and Wang CH: ER stress in adipocytes and insulin resistance: Mechanisms and significance (Review). Mol Med Rep 10: 2234-2240, 2014.
APA
Khan, S., & Wang, C.H. (2014). ER stress in adipocytes and insulin resistance: Mechanisms and significance (Review). Molecular Medicine Reports, 10, 2234-2240. https://doi.org/10.3892/mmr.2014.2532
MLA
Khan, S., Wang, C. H."ER stress in adipocytes and insulin resistance: Mechanisms and significance (Review)". Molecular Medicine Reports 10.5 (2014): 2234-2240.
Chicago
Khan, S., Wang, C. H."ER stress in adipocytes and insulin resistance: Mechanisms and significance (Review)". Molecular Medicine Reports 10, no. 5 (2014): 2234-2240. https://doi.org/10.3892/mmr.2014.2532
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team