Exenatide enhances INS-1 rat pancreatic β‑cell mass by increasing the protein levels of adiponectin and reducing the levels of C-reactive protein

  • Authors:
    • Huibiao Quan
    • Yongyi Gao
    • Huachuan Zhang
    • Tuanyu Fang
    • Daoxiong Chen
    • Zhaohui Lv
    • Yanming Chen
  • View Affiliations

  • Published online on: September 5, 2014     https://doi.org/10.3892/mmr.2014.2538
  • Pages: 2447-2452
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Abstract

Type 2 diabetes mellitus (T2DM) is a complex and heterogeneous disorder affecting >220 million individuals worldwide; this is projected to reach 366 million by 2030. Exenatide, a long‑acting glucagon‑like peptide 1 receptor agonist, exhibits potential in the treatment of T2MD due to its ability to increase β‑cell mass. However, the molecular mechanism by which exenatide increases β‑cell mass is yet to be elucidated. Exenatide function was explored in the INS‑1 rat pancreatic β‑cell line. Exenatide was found to increase adiponectin protein levels by 20% (P<0.05 versus the control group) and reduce the level of C‑reactive protein (CRP) by 50% (P<0.01 versus the control group) in INS‑1 cells, resulting in an increase in the INS‑1 rat pancreatic β‑cell mass by 20% (P<0.01 versus the control group). These findings suggest that exenatide may ameliorate T2DM by increasing adiponectin protein levels and reducing the level of CRP.
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November-2014
Volume 10 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Quan H, Gao Y, Zhang H, Fang T, Chen D, Lv Z and Chen Y: Exenatide enhances INS-1 rat pancreatic β‑cell mass by increasing the protein levels of adiponectin and reducing the levels of C-reactive protein. Mol Med Rep 10: 2447-2452, 2014
APA
Quan, H., Gao, Y., Zhang, H., Fang, T., Chen, D., Lv, Z., & Chen, Y. (2014). Exenatide enhances INS-1 rat pancreatic β‑cell mass by increasing the protein levels of adiponectin and reducing the levels of C-reactive protein. Molecular Medicine Reports, 10, 2447-2452. https://doi.org/10.3892/mmr.2014.2538
MLA
Quan, H., Gao, Y., Zhang, H., Fang, T., Chen, D., Lv, Z., Chen, Y."Exenatide enhances INS-1 rat pancreatic β‑cell mass by increasing the protein levels of adiponectin and reducing the levels of C-reactive protein". Molecular Medicine Reports 10.5 (2014): 2447-2452.
Chicago
Quan, H., Gao, Y., Zhang, H., Fang, T., Chen, D., Lv, Z., Chen, Y."Exenatide enhances INS-1 rat pancreatic β‑cell mass by increasing the protein levels of adiponectin and reducing the levels of C-reactive protein". Molecular Medicine Reports 10, no. 5 (2014): 2447-2452. https://doi.org/10.3892/mmr.2014.2538