Inhibitory effects of oligochitosan on TNF‑α, IL‑1β and nitric oxide production in lipopolysaccharide‑induced RAW264.7 cells

Zhu,Jie; Zhang,Yuanyuan; Wu,Guoyou; Xiao,Zhen; Zhou,Huanqin; Yu,Xiaomei

doi:10.3892/mmr.2014.2643

January-2015 Volume 11 Issue 1

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January-2015 Volume 11 Issue 1

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Article

Inhibitory effects of oligochitosan on TNF‑α, IL‑1β and nitric oxide production in lipopolysaccharide‑induced RAW264.7 cells

Authors:
- Jie Zhu
- Yuanyuan Zhang
- Guoyou Wu
- Zhen Xiao
- Huanqin Zhou
- Xiaomei Yu
View Affiliations / Copyright

Affiliations: Department of Clinical Laboratory, Zhejiang Hospital, Hangzhou, Zhejiang 310013, P.R. China, Department of Respiratory Medicine, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, P.R. China
Pages: 729-733
|
Published online on: October 15, 2014

https://doi.org/10.3892/mmr.2014.2643
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Abstract

Oligochitosan has been reported to possess anti‑inflammatory properties; however, the mechanism of the anti‑inflammatory effects of oligochitosan remains unknown. The present study aimed to investigate the expression levels of inflammatory cytokines and the production of nitric oxide (NO), in the nuclear factor (NF)‑κB pathway of lipopolysaccharide (LPS)‑stimulated RAW264.7 murine macrophages. The results of the present study demonstrated that different concentrations of oligochitosan could significantly lower the levels of NO, tumor necrosis factor (TNF)‑α and interleukin (IL)‑1β, released from LPS‑stimulated RAW264.7 cells. This was shown to be mediated through inhibiting the activation of the NF‑κB pathway. These results demonstrate that oligochitosan may efficiently inhibit inflammation and has the potential to be an effective anti‑inflammatory agent.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Inhibitory effects of oligochitosan on TNF‑α, IL‑1β and nitric oxide production in lipopolysaccharide‑induced RAW264.7 cells

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