|
1
|
Siegel R, Naishadham D and Jemal A: Cancer
statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar
|
|
2
|
Vaughan S, Coward JI, Bast RC Jr, et al:
Rethinking ovarian cancer: recommendations for improving outcomes.
Nat Rev Cancer. 11:719–725. 2011. View
Article : Google Scholar : PubMed/NCBI
|
|
3
|
Obeid LM, Linardic CM, Karolak LA and
Hannun YA: Programmed cell death induced by ceramide. Science.
259:1769–1771. 1993. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Venable ME, Lee JY, Smyth MJ, Bielawska A
and Obeid LM: Role of ceramide in cellular senescence. J Biol Chem.
270:30701–30708. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Babahosseini H, Roberts PC, Schmelz EM and
Agah M: Roles of bioactive sphingolipid metabolites in ovarian
cancer cell biomechanics. Conf Proc IEEE Eng Med Biol Soc.
2012:2436–2439. 2012.PubMed/NCBI
|
|
6
|
Devalapally H, Duan Z, Seiden MV and Amiji
MM: Paclitaxel and ceramide co-administration in biodegradable
polymeric nanoparticulate delivery system to overcome drug
resistance in ovarian cancer. Int J Cancer. 121:1830–1838. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Daido S, Kanzawa T, Yamamoto A, et al:
Pivotal role of the cell death factor BNIP3 in ceramide-induced
autophagic cell death in malignant glioma cells. Cancer Res.
64:4286–4293. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Hou Q, Jin J, Zhou H, et al:
Mitochondrially targeted ceramides preferentially promote
autophagy, retard cell growth, and induce apoptosis. J Lipid Res.
52:278–288. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Scarlatti F, Bauvy C, Ventruti A, et al:
Ceramide-mediated macroautophagy involves inhibition of protein
kinase B and up-regulation of beclin 1. J Biol Chem.
279:18384–18391. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Chiacchiera F and Simone C: The
AMPK-FOXO3A axis as a target for cancer treatment. Cell Cycle.
9:1091–1096. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Weidberg H, Shvets E, Shpilka T, et al:
LC3 and GATE-16/GABARAP subfamilies are both essential yet act
differently in autophagosome biogenesis. EMBO J. 29:1792–1802.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Young MM, Kester M and Wang HG:
Sphingolipids: regulators of crosstalk between apoptosis and
autophagy. J Lipid Res. 54:5–19. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Morad SA and Cabot MC:
Ceramide-orchestrated signalling in cancer cells. Nat Rev Cancer.
13:51–65. 2013. View
Article : Google Scholar : PubMed/NCBI
|
|
14
|
Pattingre S, Bauvy C, Levade T, Levine B
and Codogno P: Ceramide-induced autophagy: to junk or to protect
cells? Autophagy. 5:5582009. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Lin HX, Qiu HJ, Zeng F, et al: Decreased
expression of Beclin 1 correlates closely with Bcl-xL expression
and poor prognosis of ovarian carcinoma. PLoS One. 8:e605162013.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Maiuri MC, Zalckvar E, Kimchi A and
Kroemer G: Self-eating and self-killing: crosstalk between
autophagy and apoptosis. Nat Rev Mol Cell Biol. 8:741–752. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Kabeya Y, Mizushima N, Ueno T, et al: LC3,
a mammalian homologue of yeast Apg8p, is localized in autophagosome
membranes after processing. EMBO J. 19:5720–5728. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Aita VM, Liang XH, Murty VV, et al:
Cloning and genomic organization of beclin 1, a candidate tumor
suppressor gene on chromosome 17q21. Genomics. 59:59–65. 1999.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Cao Y and Klionsky DJ: Physiological
functions of Atg6/Beclin 1: a unique autophagy-related protein.
Cell Res. 17:839–849. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Shen Y, Li DD, Wang LL, Deng R and Zhu XF:
Decreased expression of autophagy-related proteins in malignant
epithelial ovarian cancer. Autophagy. 4:1067–1068. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Duan ZL, Peng ZL, Wang ZH and Yan NH:
Correlation of autophagy gene Beclin1 to tumorigenesis and
development of epithelial ovarian cancer. Ai Zheng. 26:258–263.
2007.(In Chinese).
|
|
22
|
Bast RC Jr, Hennessy B and Mills GB: The
biology of ovarian cancer: new opportunities for translation. Nat
Rev Cancer. 9:415–428. 2009. View
Article : Google Scholar : PubMed/NCBI
|
|
23
|
Mathew R, Kongara S, Beaudoin B, et al:
Autophagy suppresses tumor progression by limiting chromosomal
instability. Genes Dev. 21:1367–1381. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Eisenberg-Lerner A, Bialik S, Simon HU and
Kimchi A: Life and death partners: apoptosis, autophagy and the
cross-talk between them. Cell Death Differ. 16:966–975. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Shukla S, Shukla M, Maclennan GT, Fu P and
Gupta S: Deregulation of FOXO3A during prostate cancer progression.
Int J Oncol. 34:1613–1620. 2009.PubMed/NCBI
|
|
26
|
Castrillon DH, Miao L, Kollipara R, Horner
JW and DePinho RA: Suppression of ovarian follicle activation in
mice by the transcription factor FOXO3a. Science. 301:215–218.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Fei M, Zhao Y, Wang Y, et al: Low
expression of Foxo3a is associated with poor prognosis in ovarian
cancer patients. Cancer Invest. 27:52–59. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Huo HZ, Wang B, Qin J, et al:
AMP-activated protein kinase (AMPK)/Ulk1-dependent autophagic
pathway contributes to C6 ceramide-induced cytotoxic effects in
cultured colorectal cancer HT-29 cells. Mol Cell Biochem.
378:171–181. 2013. View Article : Google Scholar
|
|
29
|
Levine B, Sinha S and Kroemer G: Bcl-2
family members: dual regulators of apoptosis and autophagy.
Autophagy. 4:600–606. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Mazure NM and Pouysségur J: Atypical
BH3-domains of BNIP3 and BNIP3L lead to autophagy in hypoxia.
Autophagy. 5:868–869. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Kim H, Tu HC, Ren D, et al: Stepwise
activation of BAX and BAK by tBID, BIM, and PUMA initiates
mitochondrial apoptosis. Mol Cell. 36:487–499. 2009. View Article : Google Scholar : PubMed/NCBI
|
