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Article

Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis

  • Authors:
    • Zhiyuan Wu
    • Bin Liu
    • Cailing E
    • Jie Liu
    • Qingyu Zhang
    • Juntao  Liu
    • Nianping Chen
    • Rongyi Chen
    • Runzhi Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, P.R. China, Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, P.R. China, The Second Department of Orthopedics, Ningde Hospital, Affiliated Hospital of Fujian Medical University, Ningde, Fujian 352100, P.R. China, Laboratory of Hepatobiliary Surgery, Guangdong Medical College, Zhanjiang Key Laboratory of Hepatobiliary Diseases, Zhanjiang, Guangdong 524001, P.R. China
  • Pages: 400-404
    |
    Published online on: October 21, 2014
       https://doi.org/10.3892/mmr.2014.2716
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Abstract

Resveratrol (Res), a natural plant extract, is an effective inducer of cell apoptosis and cell cycle arrest in multiple carcinoma cell types, which has been demonstrated by its ability to inhibit the proliferation of multiple human tumor cells in vitro. Although Res possesses chemopreventive properties against several types of cancer, the molecular mechanism underlying its anticancer activity remains to be fully elucidated. The present study demonstrated that Res induced cell cycle arrest and inhibited the proliferation of human melanoma A375 (IC50=23 µM after 48 h; P<0.05) and SK‑MEL‑31 (IC50=15 µM after 48 h; P<0.05) cells. Western blot analysis demonstrated that Res induced the apoptosis of human melanoma A375 and SK‑MEL‑31 cells by upregulating the expression of Bcl‑2‑associated X protein and B‑cell lymphoma 2, possibly via the p53 pathway and activation of caspase‑9 and caspase‑3.
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Copy and paste a formatted citation
Spandidos Publications style
Wu Z, Liu B, E C, Liu J, Zhang Q, Liu J, Chen N, Chen R and Zhu R: Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis. Mol Med Rep 11: 400-404, 2015.
APA
Wu, Z., Liu, B., E, C., Liu, J., Zhang, Q., Liu, J. ... Zhu, R. (2015). Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis. Molecular Medicine Reports, 11, 400-404. https://doi.org/10.3892/mmr.2014.2716
MLA
Wu, Z., Liu, B., E, C., Liu, J., Zhang, Q., Liu, J., Chen, N., Chen, R., Zhu, R."Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis". Molecular Medicine Reports 11.1 (2015): 400-404.
Chicago
Wu, Z., Liu, B., E, C., Liu, J., Zhang, Q., Liu, J., Chen, N., Chen, R., Zhu, R."Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis". Molecular Medicine Reports 11, no. 1 (2015): 400-404. https://doi.org/10.3892/mmr.2014.2716
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Z, Liu B, E C, Liu J, Zhang Q, Liu J, Chen N, Chen R and Zhu R: Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis. Mol Med Rep 11: 400-404, 2015.
APA
Wu, Z., Liu, B., E, C., Liu, J., Zhang, Q., Liu, J. ... Zhu, R. (2015). Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis. Molecular Medicine Reports, 11, 400-404. https://doi.org/10.3892/mmr.2014.2716
MLA
Wu, Z., Liu, B., E, C., Liu, J., Zhang, Q., Liu, J., Chen, N., Chen, R., Zhu, R."Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis". Molecular Medicine Reports 11.1 (2015): 400-404.
Chicago
Wu, Z., Liu, B., E, C., Liu, J., Zhang, Q., Liu, J., Chen, N., Chen, R., Zhu, R."Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis". Molecular Medicine Reports 11, no. 1 (2015): 400-404. https://doi.org/10.3892/mmr.2014.2716
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