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Article

Sirtuin 1 activation enhances the PGC-1α/mitochondrial antioxidant system pathway in status epilepticus

  • Authors:
    • Sheng-Jun Wang
    • Xiu-He Zhao
    • Wen Chen
    • Ning Bo
    • Xian-Jin Wang
    • Zhao-Fu Chi
    • Wei Wu
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China, Department of Neurology, Jinan Central Hospital, Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China, Clinical Laboratory, People's Hospital of Shenzhen, Guangdong 518020, P.R. China, Department of Neurology, Shandong Ankang Hospital, Jining, Shandong 272051, P.R. China
  • Pages: 521-526
    |
    Published online on: October 21, 2014
       https://doi.org/10.3892/mmr.2014.2724
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Abstract

Sirtuin 1 (SIRT1) regulates numerous neuronal processes, including metabolism, antioxidation and aging, through activation of peroxisome proliferator-activated receptor coactivator 1-α (PGC-1α), an upstream regulator of mitochondrial biogenesis and function. However, the role of SIRT1 in the oxidative stress induced by seizures has yet to be elucidated. The present study aimed to investigate whether SIRT1 was involved in the activation of the PGC-1α/mitochondrial antioxidant system following status epilepticus (SE) in rats. The data demonstrated that SIRT1 expression and activity were enhanced in the rat hippocampus following SE. SIRT1 inhibition effectively blocked the SE-associated increase in PGC-1α and mitochondrial antioxidant enzymes, including superoxide dismutase 2 (SOD2) and uncoupling protein 2 (UCP2). Additionally, it was also demonstrated that the activation of SIRT1 enhanced mitochondrial electron transport chain complex I activity and increased ATP content. In conclusion, the present results suggest that SIRT1 activation may alleviate mitochondrial oxidative stress induced by seizures partially via PGC-1α signaling.
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Copy and paste a formatted citation
Spandidos Publications style
Wang S, Zhao X, Chen W, Bo N, Wang X, Chi Z and Wu W: Sirtuin 1 activation enhances the PGC-1α/mitochondrial antioxidant system pathway in status epilepticus. Mol Med Rep 11: 521-526, 2015.
APA
Wang, S., Zhao, X., Chen, W., Bo, N., Wang, X., Chi, Z., & Wu, W. (2015). Sirtuin 1 activation enhances the PGC-1α/mitochondrial antioxidant system pathway in status epilepticus. Molecular Medicine Reports, 11, 521-526. https://doi.org/10.3892/mmr.2014.2724
MLA
Wang, S., Zhao, X., Chen, W., Bo, N., Wang, X., Chi, Z., Wu, W."Sirtuin 1 activation enhances the PGC-1α/mitochondrial antioxidant system pathway in status epilepticus". Molecular Medicine Reports 11.1 (2015): 521-526.
Chicago
Wang, S., Zhao, X., Chen, W., Bo, N., Wang, X., Chi, Z., Wu, W."Sirtuin 1 activation enhances the PGC-1α/mitochondrial antioxidant system pathway in status epilepticus". Molecular Medicine Reports 11, no. 1 (2015): 521-526. https://doi.org/10.3892/mmr.2014.2724
Copy and paste a formatted citation
x
Spandidos Publications style
Wang S, Zhao X, Chen W, Bo N, Wang X, Chi Z and Wu W: Sirtuin 1 activation enhances the PGC-1α/mitochondrial antioxidant system pathway in status epilepticus. Mol Med Rep 11: 521-526, 2015.
APA
Wang, S., Zhao, X., Chen, W., Bo, N., Wang, X., Chi, Z., & Wu, W. (2015). Sirtuin 1 activation enhances the PGC-1α/mitochondrial antioxidant system pathway in status epilepticus. Molecular Medicine Reports, 11, 521-526. https://doi.org/10.3892/mmr.2014.2724
MLA
Wang, S., Zhao, X., Chen, W., Bo, N., Wang, X., Chi, Z., Wu, W."Sirtuin 1 activation enhances the PGC-1α/mitochondrial antioxidant system pathway in status epilepticus". Molecular Medicine Reports 11.1 (2015): 521-526.
Chicago
Wang, S., Zhao, X., Chen, W., Bo, N., Wang, X., Chi, Z., Wu, W."Sirtuin 1 activation enhances the PGC-1α/mitochondrial antioxidant system pathway in status epilepticus". Molecular Medicine Reports 11, no. 1 (2015): 521-526. https://doi.org/10.3892/mmr.2014.2724
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