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Article

Celecoxib attenuates cachectic events in mice by modulating the expression of vascular endothelial growth factor

  • Authors:
    • Xiaoya Xu
    • Man Jiang
    • Ying Zhang
    • Yuli Bi
    • Mingyong Han
  • View Affiliations / Copyright

    Affiliations: Cancer Therapy and Research Center, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, P.R. China
  • Pages: 289-294
    |
    Published online on: October 21, 2014
       https://doi.org/10.3892/mmr.2014.2730
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Abstract

Chronic inflammation is one of the main symptoms of cancer cachexia, and cyclooxygenase 2 inhibitors, such as celecoxib, may be beneficial in counteracting the major symptoms of this syndrome. In the current study, celecoxib was orally administered to BALB/c male mice with colon 26 adenocarcinoma. Tumor growth, survival rate, body weight and food intake of the mice with cancer cachexia were recorded during the experiments. The host inflammatory response was assessed by morphological observations and hematoxylin‑eosin staining. The serum levels of vascular endothelial growth factor (VEGF), granulocyte‑macrophage colony‑stimulating factor, interleukin‑6 and tumor necrosis factor‑α in mice with cancer cachexia were measured by ELISA. Celecoxib administration attenuated the decline in body weight and food intake of mice with cancer cachexia, and improved the survival rate of cachectic mice. Erythrocyte counts and hemoglobin concentration significantly increased in cachectic mice receiving celecoxib compared with control cachectic mice. Notably, celecoxib administration significantly reduced the serum level of VEGF in mice with colon 26 adenocarcinoma, and the cachectic events were also relieved by treatment with a VEGF antibody. The cyclooxygenase 2 inhibitor celecoxib produced positive therapeutic effects in mice with cancer cachexia. This function was regulated at least partly by downregulation of serum levels of VEGF.
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Copy and paste a formatted citation
Spandidos Publications style
Xu X, Jiang M, Zhang Y, Bi Y and Han M: Celecoxib attenuates cachectic events in mice by modulating the expression of vascular endothelial growth factor. Mol Med Rep 11: 289-294, 2015.
APA
Xu, X., Jiang, M., Zhang, Y., Bi, Y., & Han, M. (2015). Celecoxib attenuates cachectic events in mice by modulating the expression of vascular endothelial growth factor. Molecular Medicine Reports, 11, 289-294. https://doi.org/10.3892/mmr.2014.2730
MLA
Xu, X., Jiang, M., Zhang, Y., Bi, Y., Han, M."Celecoxib attenuates cachectic events in mice by modulating the expression of vascular endothelial growth factor". Molecular Medicine Reports 11.1 (2015): 289-294.
Chicago
Xu, X., Jiang, M., Zhang, Y., Bi, Y., Han, M."Celecoxib attenuates cachectic events in mice by modulating the expression of vascular endothelial growth factor". Molecular Medicine Reports 11, no. 1 (2015): 289-294. https://doi.org/10.3892/mmr.2014.2730
Copy and paste a formatted citation
x
Spandidos Publications style
Xu X, Jiang M, Zhang Y, Bi Y and Han M: Celecoxib attenuates cachectic events in mice by modulating the expression of vascular endothelial growth factor. Mol Med Rep 11: 289-294, 2015.
APA
Xu, X., Jiang, M., Zhang, Y., Bi, Y., & Han, M. (2015). Celecoxib attenuates cachectic events in mice by modulating the expression of vascular endothelial growth factor. Molecular Medicine Reports, 11, 289-294. https://doi.org/10.3892/mmr.2014.2730
MLA
Xu, X., Jiang, M., Zhang, Y., Bi, Y., Han, M."Celecoxib attenuates cachectic events in mice by modulating the expression of vascular endothelial growth factor". Molecular Medicine Reports 11.1 (2015): 289-294.
Chicago
Xu, X., Jiang, M., Zhang, Y., Bi, Y., Han, M."Celecoxib attenuates cachectic events in mice by modulating the expression of vascular endothelial growth factor". Molecular Medicine Reports 11, no. 1 (2015): 289-294. https://doi.org/10.3892/mmr.2014.2730
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