Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer

Zhu,Yi; Wu,Jian; Li,Shiqi; Wang,Xiao; Liang,Zhen; Xu,Xianglai; Xu,Xin; Hu,Zhenghui; Lin,Yiwei; Chen,Hong; Qin,Jie; Mao,Qiqi; Xie,Liping

doi:10.3892/mmr.2014.2801

February-2015 Volume 11 Issue 2

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February-2015 Volume 11 Issue 2

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Article

Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer

Authors:
- Yi Zhu
- Jian Wu
- Shiqi Li
- Xiao Wang
- Zhen Liang
- Xianglai Xu
- Xin Xu
- Zhenghui Hu
- Yiwei Lin
- Hong Chen
- Jie Qin
- Qiqi Mao
- Liping Xie
View Affiliations / Copyright

Affiliations: Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
Pages: 1004-1008
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Published online on: October 29, 2014

https://doi.org/10.3892/mmr.2014.2801
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Abstract

The mortality rate associated with prostate cancer is mainly due to metastases rather than primary organ‑confined disease. Decreasing the incidence of metastasis is important in treating prostate cancer. 4',5,7‑trihydroxyflavone (apigenin) has been demonstrated to be effective in inhibiting several types of cancer. The aim of this study was to investigate the effect and mechanism of apigenin on the movement of prostate cancer cells. In the present study, DU145 cells were treated with varying concentrations of apigenin for different time periods. Cell viability was evaluated using an MTT assay. Cell motility and invasiveness were assayed using wound healing assays and a Matrigel migration and invasion assay. Flow cytometric and western blot analyses were performed to examine the cell cycle and signaling pathways. The results demonstrated that apigenin suppressed the proliferation and inhibited the migration and invasive potential of the DU145 prostate cancer cells in a dose‑ and time‑dependent manner, which was associated with epithelial mesenchymal transition. These findings suggested that apigenin may be effective in treating human prostate cancer.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer

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