MicroRNA‑144 suppresses tumorigenesis of hepatocellular carcinoma by targeting AKT3

Ma,Ying; She,Xing‑Guo; Ming,Ying‑Zi; Wan,Qi‑Quan; Ye,Qi‑Fa

doi:10.3892/mmr.2014.2844

February-2015 Volume 11 Issue 2

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February-2015 Volume 11 Issue 2

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Article

MicroRNA‑144 suppresses tumorigenesis of hepatocellular carcinoma by targeting AKT3

Authors:
- Ying Ma
- Xing‑Guo She
- Ying‑Zi Ming
- Qi‑Quan Wan
- Qi‑Fa Ye
View Affiliations / Copyright

Affiliations: Department of Transplant Surgery, The Third Affiliated Hospital, Central South University, Changsha, Hunan 410013, P.R. China
Pages: 1378-1383
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Published online on: November 3, 2014

https://doi.org/10.3892/mmr.2014.2844
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Abstract

Aberrant expression of microRNAs (miRNAs) has been shown to be associated with the progression and metastasis of cancer. Dysregulation of miR‑144 has been observed in numerous types of cancer; however, the exact role of miR‑144 in hepatocellular carcinoma (HCC) remains unclear. The present study observed that miR‑144 was downregulated in HCC tissues and cell lines. Forced overexpression of miR‑144 suppressed proliferation, migration and invasion of HCC cells. AKT3 was identified as a direct target of miR‑144 in HCC, and this was confirmed by a luciferase activity assay and western blot analysis. Overexpression of AKT3 in miR‑144 transfected HCC cells effectively reversed the tumor suppressive effects of miR‑144. Furthermore, AKT3 expression levels were inversely correlated with miR‑144 expression levels in HCC tissues. In conclusion, the results of the present study suggest that miR‑144 may act as a tumor suppressor in HCC by targeting AKT3, and miR‑144 may be a potential therapeutic candidate for HCC.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

MicroRNA‑144 suppresses tumorigenesis of hepatocellular carcinoma by targeting AKT3

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