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Article

Effects of engineered conserved dopamine neurotrophic factor-expressing bone marrow stromal cells on dopaminergic neurons following 6-OHDA administrations

  • Authors:
    • Jiaming Mei
    • Chaoshi Niu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Anhui Province Key Laboratory of Brain Function and Brain Diseases, Hefei, Anhui 230001, P.R. China
  • Pages: 1207-1213
    |
    Published online on: November 6, 2014
       https://doi.org/10.3892/mmr.2014.2878
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Abstract

Numerous lines of evidence previously indicated that conserved dopamine neurotrophic factor (CDNF) has potential therapeutic value for Parkinson's disease (PD); however, this hypothesis remains controversial. In the present study, the therapeutic effects of engineered CDNF-expressing bone marrow stromal cells (CDNF-BMSCs) on dopaminergic (DA) neurons were evaluated in vivo. CDNF-BMSCs and control BMSCs were transplanted into the rat striatum and one week later, 6-hydroxydopamine (6-OHDA) was administered to induce neurotoxicity. It was discovered that intrastriatal transplantation of CDNF-BMSCs significantly reduced 6-OHDA-induced neurotoxicity in DA neurons with regard to behavioral recovery and tyrosine hydroxylase levels in the substantia nigra and striatum. These data therefore indicated that transplantation of engineered CDNF-BMSCs into the striatum may present a beneficial strategy for the treatment of PD.
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Copy and paste a formatted citation
Spandidos Publications style
Mei J and Niu C: Effects of engineered conserved dopamine neurotrophic factor-expressing bone marrow stromal cells on dopaminergic neurons following 6-OHDA administrations. Mol Med Rep 11: 1207-1213, 2015.
APA
Mei, J., & Niu, C. (2015). Effects of engineered conserved dopamine neurotrophic factor-expressing bone marrow stromal cells on dopaminergic neurons following 6-OHDA administrations. Molecular Medicine Reports, 11, 1207-1213. https://doi.org/10.3892/mmr.2014.2878
MLA
Mei, J., Niu, C."Effects of engineered conserved dopamine neurotrophic factor-expressing bone marrow stromal cells on dopaminergic neurons following 6-OHDA administrations". Molecular Medicine Reports 11.2 (2015): 1207-1213.
Chicago
Mei, J., Niu, C."Effects of engineered conserved dopamine neurotrophic factor-expressing bone marrow stromal cells on dopaminergic neurons following 6-OHDA administrations". Molecular Medicine Reports 11, no. 2 (2015): 1207-1213. https://doi.org/10.3892/mmr.2014.2878
Copy and paste a formatted citation
x
Spandidos Publications style
Mei J and Niu C: Effects of engineered conserved dopamine neurotrophic factor-expressing bone marrow stromal cells on dopaminergic neurons following 6-OHDA administrations. Mol Med Rep 11: 1207-1213, 2015.
APA
Mei, J., & Niu, C. (2015). Effects of engineered conserved dopamine neurotrophic factor-expressing bone marrow stromal cells on dopaminergic neurons following 6-OHDA administrations. Molecular Medicine Reports, 11, 1207-1213. https://doi.org/10.3892/mmr.2014.2878
MLA
Mei, J., Niu, C."Effects of engineered conserved dopamine neurotrophic factor-expressing bone marrow stromal cells on dopaminergic neurons following 6-OHDA administrations". Molecular Medicine Reports 11.2 (2015): 1207-1213.
Chicago
Mei, J., Niu, C."Effects of engineered conserved dopamine neurotrophic factor-expressing bone marrow stromal cells on dopaminergic neurons following 6-OHDA administrations". Molecular Medicine Reports 11, no. 2 (2015): 1207-1213. https://doi.org/10.3892/mmr.2014.2878
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