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March-2015 Volume 11 Issue 3

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Article

Berberine targets epidermal growth factor receptor signaling to suppress prostate cancer proliferation in vitro

  • Authors:
    • Zheng‑Hua Huang
    • Hong‑Fang Zheng
    • Wei‑Lu Wang
    • Yong Wang
    • Long‑Fei Zhong
    • Jiu‑Long Wu
    • Qiao‑Xing Li
  • View Affiliations / Copyright

    Affiliations: Department of Urological Surgery, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu 215300, P.R. China
  • Pages: 2125-2128
    |
    Published online on: November 12, 2014
       https://doi.org/10.3892/mmr.2014.2929
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Abstract

Berberine is a well‑known component of the Chinese herbal medicine Huanglian (Coptis chinensis), and is capable of inhibiting the proliferation of multiple cancer cell lines. However, information available regarding the effect of berberine on prostate cancer cell growth is limited. In the present study, LnCaP and PC‑3 human prostate cancer cell lines were selected as in vitro models in order to assess the efficacy of berberine as an anticancer agent. A cell proliferation assay demonstrated that berberine inhibited cell growth in a dose‑and time‑dependent manner. Further investigation revealed berberine significantly accumulated inside cells that were in the G1 phase of the cell cycle and enhanced apoptosis. Western blot analysis demonstrated that berberine inhibited the expression of prostate‑specific antigen and the activation of epidermal growth factor receptor (EGFR), and it attenuated EGFR activation following EGF treatment in vitro. In conclusion, the results indicate that berberine inhibits the proliferation of prostate cancer cells through apoptosis and/or cell cycle arrest by inactivation of the EGFR signaling pathway.
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1 

Semenas J, Allegrucci C, Boorjian SA, et al: Overcoming drug resistance and treating advanced prostate cancer. Curr Drug Targets. 13:1308–1323. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Kohli M and Tindall DJ: New developments in the medical management of prostate cancer. Mayo Clin Proc. 85:77–86. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Martin SK, Vaughan TB, Atkinson T, et al: Emerging biomarkers of prostate cancer (Review). Oncol Rep. 28:409–417. 2012.PubMed/NCBI

4 

Hilton WM, Padalecki SS, Ankerst DP, et al: Temporal changes in the clinical approach to diagnosing prostate cancer. J Natl Cancer Inst Monogr. 45:162–168. 2012. View Article : Google Scholar

5 

Paller CJ and Antonarakis ES: Management of biochemically recurrent prostate cancer after local therapy: evolving standards of care and new directions. Clin Adv Hematol Oncol. 11:14–23. 2013.PubMed/NCBI

6 

Khin-Maung U, Myo K, Nyunt-Nyunt W, et al: Clinical trial of berberine in acute watery diarrhoea. Br Med J (Clin Res Ed). 291:1601–1605. 1985. View Article : Google Scholar

7 

Han J, Lin H and Huang W: Modulating gut microbiota as an anti-diabetic mechanism of berberine. Med Sci Monit. 17:RA164–167. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Yin J, Zhang H and Ye J: Traditional chinese medicine in treatment of metabolic syndrome. Endocr Metab Immune Disord Drug Targets. 8:99–111. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Liang KW, Ting CT, Yin SC, et al: Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury. Biochem Pharmacol. 71:806–817. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Lin TH, Kuo HC, Chou FP, et al: Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide. BMC Cancer. 8:582008. View Article : Google Scholar : PubMed/NCBI

11 

Liu B, Wang G, Yang J, et al: Berberine inhibits human hepatoma cell invasion without cytotoxicity in healthy hepatocytes. PLoS One. 6:e214162011. View Article : Google Scholar : PubMed/NCBI

12 

Wang L, Liu L, Shi Y, et al: Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. PLoS One. 7:e364182012. View Article : Google Scholar : PubMed/NCBI

13 

Piyanuch R, Sukhthankar M, Wandee G, et al: Berberine, a natural isoquinoline alkaloid, induces NAG-1 and ATF3 expression in human colorectal cancer cells. Cancer Lett. 258:230–240. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Park KS, Kim JB, Bae J, et al: Berberine inhibited the growth of thyroid cancer cell lines 8505C and TPC1. Yonsei Med J. 53:346–351. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Fu L, Chen W, Guo W, et al: Berberine targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and cytochrome-C/caspase signaling to suppress human cancer cell growth. PLoS One. 8:e692402013. View Article : Google Scholar

16 

Wang L, Cao H, Lu N, et al: Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells. PLoS One. 8:e566662013. View Article : Google Scholar : PubMed/NCBI

17 

Sun KK, Ji C, Li X, et al: Overexpression of high mobility group protein B1 correlates with the proliferation and metastasis of lung adenocarcinoma cells. Mol Med Rep. 7:1678–1682. 2013.PubMed/NCBI

18 

Sun KK, Zhong N, Yang Y, et al: Enhanced radiosensitivity of NSCLC cells by transducer of erbB2.1 (TOB1) through modulation of the MAPK/ERK pathway. Oncol Rep. 29:2385–2391. 2013.PubMed/NCBI

19 

Che J, Lu YW, Sun KK, et al: Overexpression of TOB1 confers radioprotection to bronchial epithelial cells through the MAPK/ERK pathway. Oncol Rep. 30:637–642. 2013.PubMed/NCBI

20 

Li J, Cao B, Liu X, et al: Berberine suppresses androgen receptor signaling in prostate cancer. Mol Cancer Ther. 10:1346–1356. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Vidal A and Koff A: Cell-cycle inhibitors: three families united by a common cause. Gene. 247:1–15. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Mantena SK, Sharma SD and Katiyar SK: Berberine inhibits growth, induces G1 arrest and apoptosis in human epidermoid carcinoma A431 cells by regulating Cdki-Cdk-cyclin cascade, disruption of mitochondrial membrane potential and cleavage of caspase 3 and PARP. Carcinogenesis. 27:2018–2027. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Chidambara Murthy KN, Jayaprakasha GK and Patil BS: The natural alkaloid berberine targets multiple pathways to induce cell death in cultured human colon cancer cells. Eur J Pharmacol. 688:14–21. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Okada H and Mak TW: Pathways of apoptotic and non-apoptotic death in tumour cells. Nat Rev Cancer. 4:592–603. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Patil JB, Kim J and Jayaprakasha GK: Berberine induces apoptosis in breast cancer cells (MCF-7) through mitochondrial-dependent pathway. Eur J Pharmacol. 645:70–78. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Prenzel N, Fischer OM, Streit S, et al: The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification. Endocr Relat Cancer. 8:11–31. 2001. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huang ZH, Zheng HF, Wang WL, Wang Y, Zhong LF, Wu JL and Li QX: Berberine targets epidermal growth factor receptor signaling to suppress prostate cancer proliferation in vitro. Mol Med Rep 11: 2125-2128, 2015.
APA
Huang, Z., Zheng, H., Wang, W., Wang, Y., Zhong, L., Wu, J., & Li, Q. (2015). Berberine targets epidermal growth factor receptor signaling to suppress prostate cancer proliferation in vitro. Molecular Medicine Reports, 11, 2125-2128. https://doi.org/10.3892/mmr.2014.2929
MLA
Huang, Z., Zheng, H., Wang, W., Wang, Y., Zhong, L., Wu, J., Li, Q."Berberine targets epidermal growth factor receptor signaling to suppress prostate cancer proliferation in vitro". Molecular Medicine Reports 11.3 (2015): 2125-2128.
Chicago
Huang, Z., Zheng, H., Wang, W., Wang, Y., Zhong, L., Wu, J., Li, Q."Berberine targets epidermal growth factor receptor signaling to suppress prostate cancer proliferation in vitro". Molecular Medicine Reports 11, no. 3 (2015): 2125-2128. https://doi.org/10.3892/mmr.2014.2929
Copy and paste a formatted citation
x
Spandidos Publications style
Huang ZH, Zheng HF, Wang WL, Wang Y, Zhong LF, Wu JL and Li QX: Berberine targets epidermal growth factor receptor signaling to suppress prostate cancer proliferation in vitro. Mol Med Rep 11: 2125-2128, 2015.
APA
Huang, Z., Zheng, H., Wang, W., Wang, Y., Zhong, L., Wu, J., & Li, Q. (2015). Berberine targets epidermal growth factor receptor signaling to suppress prostate cancer proliferation in vitro. Molecular Medicine Reports, 11, 2125-2128. https://doi.org/10.3892/mmr.2014.2929
MLA
Huang, Z., Zheng, H., Wang, W., Wang, Y., Zhong, L., Wu, J., Li, Q."Berberine targets epidermal growth factor receptor signaling to suppress prostate cancer proliferation in vitro". Molecular Medicine Reports 11.3 (2015): 2125-2128.
Chicago
Huang, Z., Zheng, H., Wang, W., Wang, Y., Zhong, L., Wu, J., Li, Q."Berberine targets epidermal growth factor receptor signaling to suppress prostate cancer proliferation in vitro". Molecular Medicine Reports 11, no. 3 (2015): 2125-2128. https://doi.org/10.3892/mmr.2014.2929
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